About the Lab

The MitoMed Lab investigates MITOchondrial Morphology & Dynamics to understand how mitochondrial plasticity shapes liver disease and cancer, including the emergence of distinctive structures such as megamitochondria.

Our research bridges fundamental mitochondrial biology with translational human models to understand how mitochondrial plasticity, morphology, and dynamics drive cellular adaptation and maladaptation in health and disease. We focus on mapping mitochondrial plasticity in human liver tissue, exploring how mitochondria adapt, fail, and communicate across the liver’s complex cellular network.

By combining patient-derived 3D organotypic models, including precision cut liver slices, with advanced imaging approaches, we dissect mitochondrial behaviour directly in human tissue. This enables us to study mitochondrial remodelling in physiologically relevant contexts across steatotic liver disease, alcohol related liver disease, and primary liver cancers such as cholangiocarcinoma.

Lab Culture

We foster a culture of openness, respect, transparency, shared ownership, and care, where ideas are welcomed, challenges are addressed together, and individuals are supported to take intellectual risks. We value strong work ethics, passion, high standards, and mutual support, creating an environment in which rigorous and creative science can thrive.

Mentorship is a central part of this environment, and our researchers have successfully secured international grants and fellowships, including Research Society on Alcohol Doctoral Awards, Neil Blenkinsop Research Grant, COST Action Short Term Scientific Missions, and institutional scholarships.