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Elena Palma

Dr Elena Palma

Principal Investigator and Lecturer (Adj/Hon)

Biography

Dr Elena Palma completed her Master and PhD at the University of Padova, Italy, under the supervision of Professor Paolo Bernardi, investigating the pathophysiological role of mitochondrial in muscular dystrophies and acute liver failure, and gaining extensive expertise in mitochondrial functional assays.

Following her PhD, she joined the Institute of Hepatology, Foundation for Liver Research, where she established human precision-cut liver and tumour slice (PCLS) technology and a comprehensive mitochondrial analysis platform, including ethical frameworks, tissue logistics, and experimental pipelines. These efforts enabled a series of publications positioning PCLS as a discovery and preclinical testing tool for steatotic liver disease and liver cancer. Furthermore, Dr Palma has played a key role in the dissemination of PCLS technology, including organising two EASL basic science schools on this topic.

Dr Palma conceived and led the first studies demonstrating that perturbations in mitochondrial dynamics contribute to alcohol-related liver disease and pioneering the investigation of megamitochondria in basic research studies on alcohol hepatotoxicity.

Since 2023, she is the Principal Investigator of the MitoMed lab. Her current research focuses on mitochondrial remodelling in the liver in response to metabolic, inflammatory, and alcohol related stressors, as well as in liver cancer, with the aim of elucidating disease mechanisms and identifying novel therapeutic targets.

Dr Palma is also theme lead for steatotic liver disease within her department and is actively involved in the European Society for Biomedical Research on Alcoholism, where she contributes to collaborative research initiatives across Europe.

Research

Palma Lab
Palma Lab - Mitochondrial Medicine

The Palma Lab’s mission is to develop novel multi-pronged treatments for liver diseases, especially Alcohol-related Liver Disease (ALD) and liver cancers.

mito etching -neeli 2021 - square
Immunometabolism (iMet) Research Interest Group (RIG)

The aim of the i-met research interest group is to stimulate novel collaborations in the field of Immunometabolism, a young but rapidly growing field of research.

News

Drug reshapes tissue architecture to reduce damage in alcohol-related liver disease

A new study has shed light on how a type of drug works to reduce liver damage in alcohol-related liver disease, by reshaping the architecture of the tissue....

Liver slice with fluorescent ECM staining - credit, Palma Lab, RW-ILS

Research

Palma Lab
Palma Lab - Mitochondrial Medicine

The Palma Lab’s mission is to develop novel multi-pronged treatments for liver diseases, especially Alcohol-related Liver Disease (ALD) and liver cancers.

mito etching -neeli 2021 - square
Immunometabolism (iMet) Research Interest Group (RIG)

The aim of the i-met research interest group is to stimulate novel collaborations in the field of Immunometabolism, a young but rapidly growing field of research.

News

Drug reshapes tissue architecture to reduce damage in alcohol-related liver disease

A new study has shed light on how a type of drug works to reduce liver damage in alcohol-related liver disease, by reshaping the architecture of the tissue....

Liver slice with fluorescent ECM staining - credit, Palma Lab, RW-ILS