Periodontology and Periodontal Medicine

Mission: Research into periodontal and peri-implant diseases with the aim to improve patient care and quality of life. This is done by studying mechanisms of disease pathogenesis and interactions with systemic health, and by carrying out translational treatment studies, ranging from minimally-invasive treatment to tissue-engineering.

Members

Koula Asimakopoulou

Reader in Health Psychology

Priya Bahal

Academic Clinical Fellow

Veronica Booth

Senior Lecturer in Periodontology

Mandeep Ghuman

Senior Lecturer / Honorary Consultant in Periodontology

Francis Hughes

Professor of Periodontology

Mark Ide

Joint Associate Dean for Postgraduate Taught Education

Emily Lu

Clinical Lecturer / Honorary Consultant in Periodontology

Vitor Neves

Academic Clinical Lecturer and Periodontology Registrar

Luigi Nibali

Professor of Periodontology

Svetislav Zaric

NIHR Academic Clinical Lecturer and Specialist Registrar in Periodontology

Patho-aetiology of Periodontal diseases

Identification of aetiopathogenetic mechanisms of periodontal and peri-implant disease including microbial, genetic, behavioural and environmental factors. This is done by using a range of basic and translational methodologies for host genetic and microbial analysis and for the study of biomarkers and other indicators suitable for early detection/prevention of periodontitis and for prediction and ultimately improvement of treatment outcome.

Periodontal Medicine

Study of mechanisms of associations between periodontal disease and systemic diseases and conditions such as diabetes, metabolic syndrome, adverse pregnancy outcomes, Alzheimer’s disease and cognitive decline. This involves epidemiological and translational studies to detect associations and diagnostic biomarkers.

Minimally-invasive, reconstructive and regenerative periodontal treatments

Investigation into personalised treatments for advanced periodontal lesions such as intrabony defects and furcation involvement, ranging from studies of fundamental periodontal cell biology to understand effects of complex regenerative approaches with the aim of developing novel tissue-engineering treatment strategies and pathways to minimally-invasive non-surgical therapy. This is combined with behavioural and other interventions aimed at secondary prevention and at improving patients’ quality of life.

Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence
Mainas, G., Nibali, L., Ide, M., Al Mahmeed, W., Al-Rasadi, K., Al-Alawi, K., Banach, M., Banerjee, Y., Ceriello, A., Cesur, M. & Rizzo, M., 26 Dec 2022, In: Metabolites. 23, p. 40 17 p., 13010040. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3390/metabo13010040
Periodontitis and implant complications in diabetes
Nibali, L., Gkranias, N., Mainas, G. & Di Pino, A., Oct 2022, In: PERIODONTOLOGY 2000. 90, 1, p. 88-105 18 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1111/prd.12451
Expression of periodontitis susceptibility genes in human gingiva using single-cell RNA sequencing
Caetano, A. J., D'Agostino, E. M., Sharpe, P. & Nibali, L., Dec 2022, In: Journal of Periodontal Research. 57, 6, p. 1210-1218 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/jre.13057
Evaluating Clinical Utility of Subgingival and Salivary Endotoxin Activity Levels as Periodontal Biomarkers
Zaric, S., Strachan, A., Kurushima, Y., Dong, B., Mcilwaine, C., Harrington, Z., Nibali, L., Foey, A. & Ide, M., 1 Nov 2022, In: Frontiers in Oral health. 9 p., 1029806. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/froh.2022.1029806
Implementation of a software application in staging and grading of periodontitis cases
Marini, L., Tonetti, M. S., Nibali, L., Sforza, N. M., Landi, L., Cavalcanti, R., Rojas, M. A. & Pilloni, A., 2022, (Accepted/In press) In: Oral Diseases. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/odi.14370
Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis
Sari, A., Dogan, S., Nibali, L. & Koseoglu, S., Dec 2022, In: CLINICAL ORAL INVESTIGATIONS. 26, 12, p. 7209-7218 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1007/s00784-022-04681-w
Retrospective exploratory study of smoking status and e-cigarette use with response to non-surgical periodontal therapy
Shah, C., Holtfreter, B., Hughes, F. J. & Nibali, L., 2022, (Accepted/In press) In: Journal of Periodontology. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/JPER.21-0702
Comparison of the efficacy of periodontal prognostic systems in predicting tooth loss
Saydzai, S., Buontempo, Z., Patel, P., Hasan, F., Sun, C., Akcalı, A., Lin, G. H., Donos, N. & Nibali, L., Aug 2022, In: Journal of Clinical Periodontology. 49, 8, p. 740-748 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/jcpe.13672
Managing the systemic impact of Periodontitis
Mainas, G., Ide, M., Rizzo, M., Magan-Fernandex, A., Mesa, F. & Nibali, L., 29 Apr 2022, In: Medicina. 58, 5, 621. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3390/medicina58050621
New Insights into the Pathogenesis of Periodontal Diseases
Zaric, S., Ide, M. & Nibali, L., 19 Apr 2022, In: Dental Update. 49, 4, p. 314-317 4 p. Research output: Contribution to journal › Review article › peer-review

View all publications

M. Ide, P Preshaw £212,426

Colgate Palmolive Company 2015-2016

“A randomized, parallel group study (with positive control group) to compare the efficacy on plaque and gingivitis"

Ide £4,749

OHI (Previsor) Research Awards 2015, Oral and Dental Research Trust

“Validation of Oral Health Assessment in Twins UK Study Cohort.”

P Preshaw, M. Ide, L Trombelli £136,930

Colgate Palmolive Company 2016-2018

“Clinical evaluation used as an adjunct therapy to standard routine scaling in patients with moderate to severe periodontal disease”

L.Nibali £3,500

OHI (Previsor) Research Awards June 2019, Oral and Dental Research Trust

“Prevention of tooth loss in supportive periodontal therapy: analysis of two cohorts”

Bahal, M. Ghuman £6,500

GSK Award, Oral and Dental Research Trust, 2018

Regulation of tissue regeneration by periodontal ligament stem cell derived exosomes

Moyes, M.Ghuman £263,880

Unilever UK, 2019

Integrative omics analysis of gingivitis - Measurement of Gene Expression, protein (and lipid) expression and local microbiome in samples of healthy and inflamed gingival tissue

British Society of Periodontology

The Society has already held two successful Scientific Meetings in 2019, as well as contributing to a number of national and international bodies including working with, and advising, the GDC, DoH, EFP and HEE. BSP also runs around 12 webinars annually alongside supporting research, clinical training, and public and professional awareness of periodontal health.

British Society of Periodontology Website

King's Spring Blood Brain Barrier Consortium with Industry Meeting

(Effects of periodontal infection and inflammation on the BBB, with implications for aging/dementia and drug delivery), King’s College London, April 2019 Dr Mark Ide was an invited speaker at this international event, focusing on contemporary science related to the blood brain barrier and inflammatory systemic and local disease.

Payvand Menhadji

Yuko Kurushima

Antonio Magan Fernandez