Postdoctoral Research Associate
Wellcome Trust Clinical Career Development Fellow
Investigating gene regulatory networks in germ cells using multi-modal techniques.
Recent work from our group has identified the activity of gene regulatory networks in spermatogonial stem cells (SSCs), while a number of these map to the X chromosome. The functions of these genes in SSC physiology are poorly understood. We aim to obtain a better understanding of these networks in SSCs using a combination of single-cell transcriptomic and epigenetic profiling methods.
Techniques: cell culture, hiPSCs, gene modulation
Effects of X-dosage on germ cell transcriptional identity
We have shown previously that germ cells exhibit unique dosage compensation states, which depend on the number of X chromosomes present. In this project we want to understand how gene expression networks in the germline may be altered by X chromosome dose.
Techniques: mouse developmental genetics, FACS, single-cell transcriptomics / CutNTag
The Sangrithi lab is funded by a Clinical Career Development Fellowship from the Wellcome Trust.