Dr Mahesh Sangrithi is a Wellcome Trust Clinical Career Development Fellow in the Centre for Stem Cell Research & Regenerative Medicine, School of Basic & Medical Biosciences.
Dr Mahesh Sangrithi is an academic clinician-scientist and Consultant in Obstetrics and Gynaecology. He graduated from St. George’s Hospital Medical School, London, in 1999. He obtained his PhD from the University of Cambridge at the MRC Cancer Cell Unit/CRC Department of Oncology under the supervision of Professor Ashok Venkitaraman. Dr Sangrithi went on to specialise in Obstetrics and Gynaecology at University College London, during which he also undertook postdoctoral research training as an NIHR Clinical Lecturer the Division of Stem Cells and Genetics at the National Institute of Medical Research London, where he worked on the functional effects of sex chromosomes in germ cell development, genomewide reprogramming and early embryo development.
Dr Sangrithi gained accreditation as a sub-specialist in Reproductive Medicine & Surgery, and was appointed as Consultant Gynaecologist at Addenbrooke’s Hospital in 2015. He subsequently took up an appointment in Singapore having been awarded a NMRC Clinician Scientist Investigator award, enabling him to set up his independent research group at SingHealth/Duke-NUS Graduate Medical School. Dr Sangrithi recently relocated to the United Kingdom having received a Wellcome Trust Clinical Career Development Fellowship and has relocated to London as a group leader at the Centre for Stem Cells & Regenerative Medicine at King's.
Dr Sangrithi's group researches the effects of the sex chromosomes in germ cell development and causes for infertility. The transcriptional identity of male and female germ cells is established during early embryonic development and arises from an interplay of cell autonomous and extrinsic cues from supporting somatic cells. A mismatch between the complement of sex chromosomes and phenotypic sex leads to infertility – i.e. observed in Klinefelter syndrome (males with an extra X; XXY) and Turner syndrome (females with X monosomy (XO). The group focuses on germ cell sexual dimorphism in the following areas:
- Transcription factor sub-networks in germ cells.
- Sex chromosome effects in germ cells – determinants of germ cell transcriptional identity
- High-resolution developmental maps of oogenesis and spermatogenesis using single-cell approaches
Please contact Dr Sangrithi if you are interested in PhD/postdoctoral opportunities. Any vacant posts within the Centre for Stem Cells & Regenerative Medicine are advertised on the King's HireWire website.
Lau, X., Yong, P. J. A., Lou, C. K. L., Munusamy, P. & Sangrithi, M., 19 Mar 2021, In: STAR Protocols. 2, 1, 100294. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.xpro.2021.100294
Mahadevaiah, S. K., Sangrithi, M. N., Hirota, T. & Turner, J. M. A., 19 Sep 2020, (E-pub ahead of print) In: Nature. 586, 7830, p. 612-617 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41586-020-2629-6
Lau, X., Munusamy, P., Ng, M. J. & Sangrithi, M., 24 Aug 2020, In: Developmental Cell. 54, 4, p. 548-+ Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.devcel.2020.07.018
ElInati, E., Zielinska, A. P., McCarthy, A., Kubikova, N., Maciulyte, V., Mahadevaiah, S., Sangrithi, M. N., Ojarikre, O., Wells, D., Niakan, K. K., Schuh, M. & Turner, J. M. A., 25 May 2020, In: Nature Communications. 11, 1 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-020-16441-z
Sangrithi, M. N. & Turner, J. M. A., Jun 2018, In: Bioessays. 40, 6 Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1002/bies.201800024
Sangrithi, M. N., Royo, H., Mahadevaiah, S. K., Ojarikre, O., Bhaw, L., Sesay, A., Peters, A. H. F. M., Stadler, M. & Turner, J. M. A., 6 Feb 2017, In: Developmental Cell. 40, 3, p. 289-301 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.devcel.2016.12.023
Grant, J., Mahadevaiah, S. K., Khil, P., Sangrithi, M. N., Royo, H., Duckworth, J., McCarrey, J. R., VandeBerg, J. L., Renfree, M. B., Taylor, W., Elgar, G., Camerini-Otero, R. D., Gilchrist, M. J. & Turner, J. M. A., 12 Jul 2012, In: Nature. 487, 7406, p. 254-8 5 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/nature11171