We study mechanical forces controlling epithelial cell turnover. We discovered that excess epithelial cells get extruded by their neighbouring cells. Extrusion is essential for maintaining a functional barrier and we now find several deadly, yet common disease hijack this process, including metastatic cancer and asthma.
Publications
Awards
- Extrusion and Homeostasis
National Inst. General Medical Sciences RO1 Role: Principal Investigator - Inhibiting bronchoconstriction-dependent airway epithelial extrusion to block the asthma inflammatory cycle American Asthma Foundation
Role: Principal Investigator - Faculty Scholars Award, Howard Hughes Medical Institute Role: Principal Investigator
Publications
Awards
- Extrusion and Homeostasis
National Inst. General Medical Sciences RO1 Role: Principal Investigator - Inhibiting bronchoconstriction-dependent airway epithelial extrusion to block the asthma inflammatory cycle American Asthma Foundation
Role: Principal Investigator - Faculty Scholars Award, Howard Hughes Medical Institute Role: Principal Investigator
Our Partners
American Asthma Foundation
National Institute of General Medical Sciences
Howard Hughes Medical Institute