We are fascinated by the inherent plasticity of seemingly differentiated pancreatic cells and the molecular cues behind cell fate changes. Our previous work uncovered a latent capacity for regeneration in the pancreas, which could be harnessed to replace crucial insulin-producing cells lost to disease. Our main goal in the Sancho lab is to decipher the fundamental regulatory networks involved in pancreatic cell fate decisions using adult and iPSCs derived organoids, and to apply this knowledge to new strategies in regenerative medicine for diabetes.