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Rocio Sancho

Dr Rocio Sancho

Group Leader / Senior Lecturer

Research interests

  • Diabetes
  • Immunology

Biography

Rocio Sancho obtained her PhD in immunology at the University of Cordoba (Spain). She completed her postdoctoral research in the Mammalian Genetics lab at the Cancer Research UK London Research Institute where she specialised in studying intestinal tissue stem cells and their function in homeostasis and cancer. As a Senior Scientist in the Adult Stem Cell lab at the Francis Crick Institute she turned her interests in mammalian cell differentiation to the study of cell fate decisions in adult pancreatic progenitors and began to explore their potential to treat diabetes. Rocio Sancho started her independent career as a Group Leader in the Centre for Stem Cells & Regenerative Medicine at King’s in 2017.

Research interests

Our group is fascinated by the inherent plasticity of seemingly differentiated pancreatic cells and the molecular cues behind cell fate changes. Our work uncovered a latent capacity for regeneration in the pancreas, which could be harnessed to replace crucial insulin-producing cells lost to disease. The main goal in our lab is to decipher the fundamental regulatory networks involved in pancreatic cell fate decisions using adult pancreas organoids and induced pluripotent stem cells (iPSCs), and to apply this knowledge to new strategies in regenerative medicine for diabetes.

    Research

    sancholabhero
    Sancho Lab

    Our main goal in the Sancho lab is to decipher the fundamental regulatory networks involved in pancreatic cell fate decisions using adult and iPSCs derived organoids, and to apply this knowledge to new strategies in regenerative medicine for diabetes.

    From Dev Biology to Regen Medicine-hero
    From Developmental Biology to Regenerative Medicine

    Understanding organ development and tissue regeneration provides a framework for elucidating disease mechanisms as well as for developing new therapeutics.

    News

    £4.8 million awarded to King's scientists to help find cure for type 1 diabetes

    Two major research projects, led by Professor Shanta Persaud and Dr Aileen King, and Professor Francesca Spagnoli, Dr Rocio Sancho and Professor Molly Stevens...

    main-diabetes

    Study unravels new disease mechanism for monogenic diabetes

    Article in Cell Reports reveals an unknown developmental defect that could happen in MODY3 patients and might explain the increase in disease severity across...

    iPSCs derived beta cells using the organoid system

      Research

      sancholabhero
      Sancho Lab

      Our main goal in the Sancho lab is to decipher the fundamental regulatory networks involved in pancreatic cell fate decisions using adult and iPSCs derived organoids, and to apply this knowledge to new strategies in regenerative medicine for diabetes.

      From Dev Biology to Regen Medicine-hero
      From Developmental Biology to Regenerative Medicine

      Understanding organ development and tissue regeneration provides a framework for elucidating disease mechanisms as well as for developing new therapeutics.

      News

      £4.8 million awarded to King's scientists to help find cure for type 1 diabetes

      Two major research projects, led by Professor Shanta Persaud and Dr Aileen King, and Professor Francesca Spagnoli, Dr Rocio Sancho and Professor Molly Stevens...

      main-diabetes

      Study unravels new disease mechanism for monogenic diabetes

      Article in Cell Reports reveals an unknown developmental defect that could happen in MODY3 patients and might explain the increase in disease severity across...

      iPSCs derived beta cells using the organoid system