Structural studies on bacterial and viral drug targets We study the mechanism of action of type II DNA topoisomerases using a structural and functional approach in collaboration with Prof. Mark Fisher's group at the Institute of Medical and Clincal Sciences, St. George's, University of London. The structural techniques which we use as primarily X-ray Crystallography and CryoEM, which are best suited for resolving very high molecular weight topoisomerase-DNA-drug complexes at close to atomic resolution. The type II topoisomerases are very important drug bacterial targets for medically administered fluoroquinolones. Structural studies of proteins and molecular complexes involved in viral infection and their role or potential as drug targets are also part of our research interest in the areas of Herpes, HIV and SARS-Cov-2. When the molecular weight of the macromolecular complex is suitable we have also used High Field NMR to solve the stuctures of the complexes.