The Warnatsch group studies the localisation and effects of neutrophil reactive oxygen species (ROS) during respiratory virus infections.
Neutrophils are innate immune cells that produce a powerful oxidative burst and play a crucial role in clearing infections. However, poor regulation of neutrophils and their ROS production causes tissue damage. For example, during severe respiratory virus infections such as with Influenza A virus or SARS-CoV-2 an excessive inflammatory neutrophil response is exacerbating pathology. We are investigating how neutrophil ROS signalling affects antiviral inflammation and virus clearance.
Our Partners
Wellcome Trust
Royal Society
Group lead
Sir Henry Dale Fellow