Professor Adil Mardinoglu Academics Supervisors Professor of Systems Biology Research subject areas Host-Microbiome Interactions Contact details adil.mardinoglu@kcl.ac.uk
A human pan-disease blood atlas of the circulating proteome Anticancer effects and mechanisms of Pulsatilla chinensis, Bupleurum chinense and Polyporus umbellatus on human lung carcinoma and hepatoma cells Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies Microbiome signatures of virulence in the oral-gut-brain axis influence Parkinson’s disease and cognitive decline pathophysiology Multi-Omics biological embeddings for ML-models Multi-omics characterization of improved cognitive functions in Parkinson’s disease patients after the combined metabolic activator treatment: a randomized, double-blinded, placebo-controlled phase II trial Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats Synthesis of novel tetrahydrobenzo[b]thiophene-3-carbonitrile (THBTC)-based heterocycles: Structural insights, reactivity profiles, and in-silico bioactivity studies Systematically identification of survival-associated eQTLs in a Japanese kidney cancer cohort Targeting PKLR in liver diseases The Human Pathology Atlas for deciphering the prognostic features of human cancers Unravelling the Complexity of Sarcopenia Through a Systems Biology Approach Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases Corrigendum to “Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning” [eBioMedicine, 2022;83:104214] (eBioMedicine (2022) 83, (S2352396422003966), (10.1016/j.ebiom.2022.104214)) Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer Discovery of a Therapeutic Agent for Glioblastoma Using a Systems Biology-Based Drug Repositioning Approach Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins Drug repositioning for immunotherapy in breast cancer using single-cell analysis Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability Genome-wide expression analysis in a Fabry disease human podocyte cell line Global compositional and functional states of the human gut microbiome in health and disease High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348 Identification of SPP1 + macrophages as an immune suppressor in hepatocellular carcinoma using single-cell and bulk transcriptomics Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention Multi-omics analysis reveals the key factors involved in the severity of the Alzheimer’s disease Multi-omics characterization of lymphedema-induced adipose tissue resulting from breast cancer-related surgery Novel drug targets and molecular mechanisms for sarcopenia based on systems biology Oral-gut microbiome interactions in advanced cirrhosis: characterisation of pathogenic enterotypes and salivatypes, virulence factors and antimicrobial resistance Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives Transient colonizing microbes promote gut dysbiosis and functional impairment Unveiling the Molecular Mechanisms of Glioblastoma through an Integrated Network-Based Approach Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy RETRACTED: Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases Revisiting the role of serine metabolism in hepatic lipogenesis Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation The acute effect of different NAD+ precursors included in the combined metabolic activators A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma Ameliorative Effects by Hexagonal Boron Nitride Nanoparticles against Beta Amyloid Induced Neurotoxicity Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies Author Correction: Spatiotemporal dissection of the cell cycle with single-cell proteogenomics (Nature, (2021), 590, 7847, (649-654), 10.1038/s41586-021-03232-9) BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study View all publications
28 June 2021 Clinical trial shows metabolic activators accelerates recovery in COVID-19 patients A collaborative study led by King’s College London has found that metabolic activators can reduce…