Professor Benedikt Berninger

Biography

I lead my own lab group within the Centre for Developmental Neurobiology and supervise several PhD and MSc students. My lab’s research primarily focuses on how to initiate neurogenesis in the mammalian brain, as typically most adult mammals are incapable of regenerating neurons after embryonic development. We do this by converting support cells into induced neurons, using in vitro and in vivo virus-based models. We also study neural stem cell models, to further inform our research in integrating newly generated neurons within existing networks. We hope that our research will ultimately pave the way for new strategies for regenerating the diseased brain in humans. Our work is supported by the Wellcome Trust.

Please see my  Research Staff Profile for more detail.

Find out more about my research:

• CDN - Benedikt Berninger
• Berninger Lab Facebook

Key Publications:

• Tiwari et al., 2018. Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes. Cell Stem Cell.
• Karow et al., 2018. Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. Nature Neuroscience.
• Heinrich et al., 2015. In vivo reprogramming for tissue repair. Nature Cell Biology.
• Bergami et al., 2015. A critical period for experience-dependent remodeling of adult-born neuron connectivity. Neuron.
• Ortega et al., 2013. Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling. Nature Cell Biology.

View all publications

Key Collaborators:

• Professor Guillermina Lopez-Bendito, Universidad Miguel Hernández
• Dr Francois Guillemot, The Francis Crick Institute
• Dr Nicholas Luscombe, The Francis Crick Institute
• Professor Oscar Marin, King's College London