Dr. Bini Ramachandran is a mass spectrometry and proteomics specialist with extensive experience across academic research, proteomics core laboratories, and the instrumentation industry. Her work focuses on developing robust, fit‑for‑purpose proteomics workflows and applying advanced mass spectrometry to address complex biological and translational research questions.

Bini completed her PhD at Madurai Kamaraj University in India, where she used plasma proteomics to investigate host–pathogen interactions in Mycobacterium leprae infection. Her early postdoctoral work in India involved developing innovative membrane and organelle proteomics and lipidomic approaches, including fluorescence‑assisted organelle sorting and lysis‑free membrane isolation. This research, supported by competitive national fellowships, contributed to collaborative studies in infectious disease, cancer biology, and microbial biotechnology.

At the University of Nebraska–Lincoln, Bini developed specialised targeted mass spectrometry methods for food allergen detection. This work included establishing highly sensitive LC–MS/MS assays, validating their performance across diverse food matrices, and introducing a matrix‑independent calibration strategy that improved quantitative accuracy.

Bini later joined the MRC Toxicology Unit at the University of Cambridge as Proteomics Technical Lead. There she designed and delivered a wide range of proteomics workflows, including global quantitative proteomics, thermal proteome profiling, immunopeptidomics, protein interaction mapping, microbiome proteomics, and PTM profiling. She oversaw instrument performance, workflow standardisation, and core facility operations, as well as generating proof‑of‑concept data for implementing single‑cell proteomics in core laboratory settings.

Most recently, as Director of Proteomics at a contract research organisation, Bini established chemo-proteomics focused services supporting covalent and non‑covalent drug discovery. Her role spanned workflow development, team training, client engagement, and strategic planning.

Bini’s background further includes experience in the instrumentation industry as an Application Specialist, demonstrating niche high‑resolution mass spectrometry workflows for proteomics applications, developing application methods for biotherapeutic characterisation, training users, and supporting pre‑ and post‑sales technical activities.

In September 2025, Bini joined the King’s Proteomics Core Facility as Manager, overseeing facility operations and ensuring the delivery of high‑quality mass spectrometry services to academic and industrial users, aligned with their research objectives.