Professor David Edwards MA MBBS DSc FRCP FRCR FRCPCH FMedSci
Director, Insititute for Women & Children's Health
Research interests
- Biomedical and life sciences
- Child & Family
- Women
Biography
David Edwards is a consultant neonatologist at the Evelina London Children's Hospital and Professor of Paediatrics & Neonatal Medicine at King's College London. He has studied the mechanisms of perinatal brain damage, working to reduce death and severe neurological impairment caused by: (a) birth asphyxia, which kills more children than malaria with the annual global loss of 50 million Disability-Adjusted Life Years (DALY); and (b) brain abnormalities associated with preterm birth, which annually causes 77 million lost DALY, the 8th highest of the 291 conditions assessed by the 2010 Global Burden of Disease Study.
He has made two principal contributions:
• He discovered that the mechanism of birth asphyxia critically includes the triggering of massive neural apoptosis. He found that reduced temperature interrupts a post-asphyxial apoptotic programme and with colleagues around the world translated this discovery into the first successful treatment for birth asphyxia, now in routine use across the world.
• He implemented Magnetic Resonance Imaging (MRI) to study very preterm infants, installing an MRI scanner in the Neonatal Intensive Care Unit to allow the sickest and most vulnerable infants to be engaged in research programmes. He showed that the predominant problem after preterm birth is a widespread disruption of brain development, and discovered biochemical and genetic evidence of inflammatory mechanisms of damage which are candidates for therapeutic intervention.
He now leads the €15m European Research Council Developing Human Connectome Project, which is making available over 1000 fetal and neonatal brain MR images to allow researchers to study the development of brain connectivity in the perinatal period His work made him in 2007 only the second British winner of the prestigious Arvo Ylppo International Gold Medal and €50,000 Prize, presented by the Finnish National Academy once every 5 years. Many members of his research group have gone on to become professors and/or department heads in major institutions.
He directs the Centre for the Developing Brain in King’s College London and the King’s Health Partners Institute for Women & Children’s Health.
Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project
Le, H., Bonthrone, A., Uus, A., Fenchel, D., Lautarescu, A., Dimitrakopoulou, K., Edwards, D., Hajnal, J., Counsell, S., Cordero-Grande, L., Christiaens, D., Batalle, D., Pietsch, M., Price, A., Patel, H., Curtis, C., Cullen, H., Deprez, M. & Tournier, J.-D., 21 Jan 2025, (Accepted/In press) In: Translational psychiatry.Research output: Contribution to journal › Article › peer-review
Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing Human Connectome Project
Le, H., Fenchel, D., Dimitrakopoulou, K., Patel, H., Curtis, C., Cordero-Grande, L., Edwards, D., Hajnal, J., Tournier, J.-D., Deprez, M. & Cullen, H., 21 Jan 2025, (Accepted/In press) In: Translational psychiatry.Research output: Contribution to journal › Article › peer-review
Cortical scaling of the neonatal brain in typical and altered development
Bonthrone, A., Cromb, D., Chew, A., Gal-Er, B., Kelly, C., Falconer, S., Arichi, T., Pushparajah, K., Simpson, J., Rutherford, M., Hajnal, J., Nosarti, C., Edwards, D., O'Muircheartaigh, J. & Counsell, S., 15 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 15, e2416423122.Research output: Contribution to journal › Article › peer-review
Gestational age at birth and cognitive outcomes in term-born children: Evidence from Chinese and British cohorts
Sun, Z., Zhang, L., Ge, Q., Xiao, C., Gale-Grant, O., Falconer, S., Chew, A., Yu, C., Edwards, A. D., Nosarti, C. & Liu, Z., May 2025, In: Early Human Development. 204, 106237.Research output: Contribution to journal › Article › peer-review
The developing Human Connectome Project fetal functional MRI release: Methods and data structures
Karolis, V. R., Cordero-Grande, L., Price, A., Hughes, E., Fitzgibbon, S., Kyriakopoulou, V., Uus, A., Harper, N., Prokopenko, D., Bridglal, D., Willers Moore, J., Wilson, S., Pietsch, M., Christiaens, D., Deprez, M., Williams, L., Robinson, E., Makropoulos, A., Farahibozorg, S.-R. & O'Muircheartaigh, J. & 7 others, Rutherford, M., Rueckert, D., Edwards, D., Arichi, T., Smith, S. M., Duff, E. P. & Hajnal, J., 6 Mar 2025, (E-pub ahead of print) In: Imaging Neuroscience. 3, 23 p.Research output: Contribution to journal › Article › peer-review
Attentional development is altered in toddlers with congenital heart disease
Bonthrone, A., Kyriakopoulou, V., Mason, L., Chew, A., Falconer, S., Kelly, C., Simpson, J., Pushparajah, K., Johnson, M. H., Edwards, D., Nosarti, C., Jones, E. J. H. & Counsell, S., 22 Apr 2024, In: JCPP Advances.Research output: Contribution to journal › Article › peer-review
Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers
Gale-Grant, O., Chew, A., Falconer, S., França, L., Fenn-Moltu, S., Hadaya, L., Harper, N., Ciarrusta Monzon, J., Charman, T., Murphy, D., Arichi, T., McAlonan, G., Nosarti, C., Edwards, D. & Batalle, D., Dec 2024, In: Scientific Reports. 14, 1, 8393.Research output: Contribution to journal › Article › peer-review
Executive function in preschool children with congenital heart disease and controls: the role of a cognitively stimulating home environment.
Chew, A., Bonthrone, A., Alford, A., Kelly, C., Pushparajah, K., Egloff, A., Hajnal, J., Simpson, J., Rutherford, M., Edwards, D., Nosarti, C. & Counsell, S., Apr 2024, In: Journal of Pediatrics. 267, 113897.Research output: Contribution to journal › Article › peer-review
Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience
Bonthrone, A., Blesa Cabez, M., Edwards, A. D., Hajnal, J. V., Counsell, S. & Boardman, J. P., 8 Dec 2024, In: Developmental Cognitive Neuroscience. 71, 101488.Research output: Contribution to journal › Article › peer-review
Individualized cortical gyrification in neonates with congenital heart disease
Cromb, D., Wilson, S., Bonthrone, A., Chew, A., Kelly, C., Kumar, M., Cawley, P., Dimitrova, R., Tournier, J.-D., Pushparajah, K., Simpson, J., Rutherford, M., Hajnal, J., Edwards, D., Nosarti, C., O'Muircheartaigh, J. & Counsell, S., 7 Oct 2024, In: Brain Communications. 6, 5, fcae356.Research output: Contribution to journal › Article › peer-review
Instant interaction driven adaptive gaze control interface
Qian, K., Arichi, T., Edwards, A. D. & Hajnal, J. V., 22 May 2024, In: Scientific Reports. 14, 1, 11661.Research output: Contribution to journal › Article › peer-review
Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment
França, L., Ciarrusta Monzon, J., Gale-Grant, O., Fenn-Moltu, S., Fitzgibbon, S. P., Chew, A., Falconer, S., Dimitrova, R., Cordero-Grande, L., Price, A., Hughes, E., O'Muircheartaigh, J., Duff, E. P., Tuulari, J. J., Deco, G., Counsell, S., Hajnal, J., Nosarti, C., Arichi, T. & Edwards, D. & 2 others, McAlonan, G. & Batalle, D., 8 Feb 2024, In: Nature Communications. 15, 1, p. 16 1 p., 16.Research output: Contribution to journal › Article › peer-review
T1 and T2 Measurements of the Neonatal Brain at 7T
Mahmoud, A., Tomi-Tricot, R., Leitão, D., Bridgen, P., Uus, A., Price, A., Lawrence, A., Cromb, D., Cawley, P. A., Deprez, M., De Vita, E., Giles, S., Rutherford, M., Edwards, D., Hajnal, J., Arichi, T. & Malik, S., 26 Nov 2024, (Accepted/In press) In: Magnetic resonance in medicine.Research output: Contribution to journal › Article › peer-review
UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings
Abate, F., Adu-Amankwah, A., Ae-Ngibise, K. A., Agbokey, F., Agyemang, V. A., Agyemang, C. T., Akgun, C., Ametepe, J., Arichi, T., Asante, K. P., Balaji, S., Baljer, L., Basser, P. J., Beauchemin, J., Bennallick, C., Berhane, Y., Boateng-Mensah, Y., Bourke, N. J., Bradford, L. & Bruchhage, M. & 92 others, Lorente, R. C., Cawley, P., Cercignani, M., D Sa, V., Canha, A. D., Navarro, N. D., Dean, D. C., Delarosa, J., Donald, K. A., Dvorak, A., Edwards, A. D., Field, D., Frail, H., Freeman, B., George, T., Gholam, J., Guerrero-Gonzalez, J., Hajnal, J. V., Haque, R., Hollander, W., Hoodbhoy, Z., Huentelman, M., Jafri, S. K., Jones, D. K., Joubert, F., Karaulanov, T., Kasaro, M. P., Knackstedt, S., Kolind, S., Koshy, B., Kravitz, R., Lafayette, S. L., Lee, A. C., Lena, B., Lepore, N., Linguraru, M., Ljungberg, E., Lockart, Z., Loth, E., Mannam, P., Masemola, K. M., Moran, R., Murphy, D., Nakwa, F. L., Nankabirwa, V., Nelson, C. A., North, K., Nyame, S., O Halloran, R., O'Muircheartaigh, J., Oakley, B. F., Odendaal, H., Ongeti, C. M., Onyango, D., Oppong, S. A., Padormo, F., Parvez, D., Paus, T., Pepper, M. S., Phiri, K. S., Poorman, M., Ringshaw, J. E., Rogers, J., Rutherford, M., Sabir, H., Sacolick, L., Seal, M., Sekoli, M. L., Shama, T., Siddiqui, K., Sindano, N., Spelke, M. B., Springer, P. E., Suleman, F. E., Sundgren, P. C., Teixeira, R., Terekegn, W., Traughber, M., Tuuli, M. G., Rensburg, J. V., Váša, F., Velaphi, S., Velasco, P., Viljoen, I. M., Vokhiwa, M., Webb, A., Weiant, C., Wiley, N., Wintermark, P., Yibetal, K., Deoni, S. & Williams, S., Oct 2024, In: Developmental Cognitive Neuroscience. 69, p. 101397 101397.Research output: Contribution to journal › Article › peer-review
560 Fetal craniofacial biometry: feasibility of deep 3D MRI phenotyping in a cohort with Down syndrome using atlas-based label propagation
Matthew, J., Uus, A., Gartner, A., Cordero-Grande, L., Kyriakopoulou, V., Cromb, D., Wright, R., O'Muircheartaigh, J., Baburamani, A., Malamateniou, C., Hutter, J., Edwards, D., Hajnal, J., Rutherford, M. & Deprez, M., 2023, British Association of Perinatal Medicine and Neonatal Society.Research output: Chapter in Book/Report/Conference proceeding › Conference paper
BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI
Uus, A. U., Kyriakopoulou, V., Makropoulos, A., Fukami-Gartner, A., Cromb, D., Davidson, A., Cordero-Grande, L., Price, A. N., Grigorescu, I., Williams, L. Z. J., Robinson, E. C., Lloyd, D., Pushparajah, K., Story, L., Hutter, J., Counsell, S. J., Edwards, A. D., Rutherford, M. A., Hajnal, J. V. & Deprez, M., 27 Apr 2023, In: bioRxiv.Research output: Contribution to journal › Article
Comparing the emotional impact of the UK COVID-19 lockdown in very preterm and full-term born children
Sun, Z., Hadaya, L., Leoni, M., Dazzan, P., Simonoff, E., Counsell, S., Edwards, D., Nosarti, C. & Vanes, L., 13 Jun 2023, In: Frontiers in Child and Adolescent Psychiatry.Research output: Contribution to journal › Article › peer-review
Development of neonatal brain functional centrality and alterations associated with preterm birth
Fenn-Moltu, S., Fitzgibbon, S. P., Ciarrusta, J., Eyre, M., Cordero-Grande, L., Chew, A., Falconer, S., Gale-Grant, O., Harper, N., Dimitrova, R., Vecchiato, K., Fenchel, D., Javed, A., Earl, M., Price, A. N., Hughes, E., Duff, E. P., O'muircheartaigh, J., Nosarti, C. & Arichi, T. & 6 others, Rueckert, D., Counsell, S., Hajnal, J. V., Edwards, A. D., Mcalonan, G. & Batalle, D., 1 May 2023, In: Cerebral Cortex. 33, 9, p. 5585-5596 12 p.Research output: Contribution to journal › Article › peer-review
Development of neonatal-specific sequences for portable ultralow field magnetic resonance brain imaging: a prospective, single-centre, cohort study
UNITY Consortium, Nov 2023, In: EClinicalMedicine. 65, p. 102253 102253.Research output: Contribution to journal › Article › peer-review
Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project
Le, H., Dimitrakopoulou, K., Patel, H., Curtis, C., Cordero-Grande, L., Edwards, D., Hajnal, J., Tournier, J.-D., Deprez, M. & Cullen, H., 10 Apr 2023, In: Translational psychiatry. 13, 1, p. 121 1 p., 121.Research output: Contribution to journal › Article › peer-review
High resolution and contrast 7 tesla MR brain imaging of the neonate
Bridgen, P., Tomi-Tricot, R., Uus, A., Cromb, D., Quirke, M., Almalbis, J., Bonse, B., De la Fuente Botella, M., Maggioni, A., Cio, P. D., Cawley, P., Casella, C., Dokumaci, A. S., Thomson, A. R., Willers Moore, J., Bridglal, D., Saravia, J., Finck, T., Price, A. N. & Pickles, E. & 12 others, Cordero-Grande, L., Egloff, A., O’Muircheartaigh, J., Counsell, S. J., Giles, S. L., Deprez, M., De Vita, E., Rutherford, M. A., Edwards, A. D., Hajnal, J. V., Malik, S. J. & Arichi, T., 2023, In: Frontiers in Radiology. 3, 1327075.Research output: Contribution to journal › Article › peer-review
Individual assessment of perioperative brain growth trajectories in infants with congenital heart disease: correlation with clinical and surgical risk factors
Cromb, D., Bonthrone, A., Maggioni, A., Cawley, P., Dimitrova, R., Kelly, C., Cordero-Grande, L., Carney, O., Egloff Collado, A., Hughes, E., Hajnal, J., Simpson, J., Pushparajah, K., Rutherford, M., Edwards, D., O'Muircheartaigh, J. & Counsell, S., 8 Jul 2023, In: Journal of the American Heart Association. 12, 14, e8599.Research output: Contribution to journal › Article › peer-review
In vivo T1 mapping of neonatal brain tissue at 64 mT
Padormo, F., Cawley, P., Dillon, L., Hughes, E., Almalbis, J., Robinson, J., Maggioni, A., Botella, M. D. L. F., Cromb, D., Price, A., Arlinghaus, L., Pitts, J., Luo, T., Zhang, D., Deoni, S. C. L., Williams, S., Malik, S., O′Muircheartaigh, J., Counsell, S. J. & Rutherford, M. & 3 others, Arichi, T., Edwards, A. D. & Hajnal, J. V., Mar 2023, In: Magnetic Resonance in Medicine. 89, 3, p. 1016-1025 10 p.Research output: Contribution to journal › Article › peer-review
Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth
Vanes, L., Fenn-Moltu, S., Hadaya, L., Fitzgibbon, S. P., Cordero-Grande, L., Price, A., Chew, A., Falconer, S., Arichi, T., Counsell, S., Hajnal, J., Batalle, D., Edwards, D. & Nosarti, C., Jun 2023, In: Developmental Cognitive Neuroscience. 61, 101250.Research output: Contribution to journal › Article › peer-review
Maturational networks of human fetal brain activity reveal emerging connectivity patterns prior to ex-utero exposure
Karolis, V. R., Fitzgibbon, S. P., Cordero-Grande, L., Farahibozorg, S.-R., Price, A. N., Hughes, E. J., Fetit, A. E., Kyriakopoulou, V., Pietsch, M., Rutherford, M. A., Rueckert, D., Hajnal, J. V., Edwards, A. D., O'Muircheartaigh, J., Duff, E. P. & Arichi, T., 22 Jun 2023, In: Communications Biology. 6, 1, 661.Research output: Contribution to journal › Article › peer-review
Maturational networks of human fetal brain activity reveal emerging connectivity patterns prior to ex-utero exposure
Karolis, V., Fitzgibbon, S., Cordero-Grande, L., Farahibozorg, S.-R., Price, A., Hughes, E., Fetit, A. E., Kyriakopoulou, V., Pietsch, M., Rutherford, M., Rueckert, D., Hajnal, J., Edwards, D., O'Muircheartaigh, J., Duff, E. P. & Arichi, T., 2023, (Accepted/In press) In: Communications Biology.Research output: Contribution to journal › Article › peer-review
Objective assessment of visual attention in toddlerhood
Braithwaite, E., Kyriakopoulou, V., Mason, L., Davidson, A., Tusor, N., Harper, N., Earl, M., Datoo-Partridge, S., Young, A., Chew, A., Falconer, S., Hajnal, J. V., Johnson, M. H., Nosarti, C., Edwards, A. D. & Jones, E. J. H., 1 Jan 2023, In: bioRxiv. p. 2023.04.04.534573Research output: Contribution to journal › Article
Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks
Hadaya, L., Dimitrakopoulou, K., Vanes, L., Kanel, D., Fenn-Moltu, S., Gale-Grant, O., Counsell, S., Edwards, D., Saqi, M., Batalle, D. & Nosarti, C., Dec 2023, In: Translational psychiatry. 13, 1, 108.Research output: Contribution to journal › Article › peer-review
PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies
Victor, S., Forbes, B., Greenough, A. & Edwards, D., 27 Oct 2023, In: Pharmaceuticals. 16, 11, p. 1530 11 p., 1530.Research output: Contribution to journal › Review article › peer-review
Prenatal exposure to air pollution is associated with structural changes in the neonatal brain
Bos, B., Barratt, B., Batalle, D., Gale-Grant, O., Hughes, E., Beevers, S., Cordero-Grande, L., Price, A., Hutter, J., Hajnal, J., Kelly, F., Edwards, D. & Counsell, S., 4 Apr 2023, In: Environment International.Research output: Contribution to journal › Article › peer-review
Reliability and safety of anaesthetic equipment around an high-field 7-Tesla MRI scanner
Bridgen, P., Malik, S., Wilkinson, T., Cronin, J., Bhagat, T., Hart, N., Mc Corkell, S., Perkins, J., Tibby, S., Hanna, S., Kirwan, R., Pauly, T., Weeks, A., Charles-Edwards, G., Padormo, F., Stell, D., El-Boghdadly, K., Ourselin, S., Giles, S. & Edwards, D. & 2 others, Hajnal, J. & Blaise, B. J., 19 Feb 2023, (Accepted/In press) In: British Journal of Anaesthesia.Research output: Contribution to journal › Article › peer-review
Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain
Wilson, S., Pietsch, M., Cordero-Grande, L., Christiaens, D., Uus, A., Karolis, V. R., Kyriakopoulou, V., Colford, K., Price, A. N., Hutter, J., Rutherford, M. A., Hughes, E. J., Counsell, S. J., Tournier, J.-D., Hajnal, J. V., Edwards, A. D., O'Muicheartaigh, J. & Arichi, T., 3 Apr 2023, In: eLife. 12, e83727.Research output: Contribution to journal › Article › peer-review
Structural and functional asymmetry of the neonatal cerebral cortex
Williams, L., Fitzgibbon, S., Bozek, J., Winkler, A. M., Dimitrova, R., Poppe, T., Schuh, A., Makropoulos, A., Cupitt, J., Duff, E. P., O'Muircheartaigh, J., Grande, L. C., Price, A., Hajnal, J., Rueckert, D., Smith, S. M., Edwards, D. & Robinson, E., 31 Jan 2023, (Accepted/In press) In: Nature Human Behaviour.Research output: Contribution to journal › Article › peer-review
A Deep Generative Model of Neonatal Cortical Surface Development
Fawaz, A., Williams, L. Z. J., Edwards, A. D. & Robinson, E. C., 2022, Medical Image Understanding and Analysis - 26th Annual Conference, MIUA 2022, Proceedings. Yang, G., Aviles-Rivero, A., Roberts, M. & Schönlieb, C.-B. (eds.). Springer Science and Business Media Deutschland GmbH, p. 469-481 13 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 13413 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Attention-Driven Multi-channel Deformable Registration of Structural and Microstructural Neonatal Data
Grigorescu, I., Uus, A., Christiaens, D., Cordero-Grande, L., Hutter, J., Batalle, D., Edwards, D., Hajnal, J., Modat, M. & Deprez, M., 22 Sept 2022, Lecture Notes in Computer Science. Springer, Vol. 13575.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Brain charts for the human lifespan
3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM Team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, Mayo Clinic Study of Aging, NSPN, POND, PREVENT-AD Research Group & VETSA & 1 others, Morgan, S., 21 Apr 2022, In: Nature. 604, 7906, p. 525-533 9 p.Research output: Contribution to journal › Article › peer-review
Development of functional organization within the sensorimotor network across the perinatal period
Dall'Orso, S., Arichi, T., Fitzgibbon, S. P., Edwards, D., Burdet, E. & Muceli, S., 11 Jan 2022, (Accepted/In press) In: Human Brain Mapping.Research output: Contribution to journal › Article › peer-review
Development of neonatal brain functional centrality and alterations associated with preterm birth
Fenn-Moltu, S., Fitzgibbon, S. P., Ciarrusta, J., Eyre, M., Cordero-Grande, L., Chew, A., Falconer, S., Gale-Grant, O., Harper, N., Dimitrova, R., Vecchiato, K., Fenchel, D., Javed, A., Earl, M., Price, A., Hughes, E., Duff, E. P., O'Muircheartaigh, J., Nosarti, C. & Arichi, T. & 6 others, Rueckert, D., Counsell, S., Hajnal, J., Edwards, D., McAlonan, G. & Batalle, D., 20 Nov 2022, In: Cerebral Cortex.Research output: Contribution to journal › Article › peer-review
Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups
Hadaya, L., Vanes, L., Karolis, V. R., Kanel, D., Leoni, M., Happe, F., Edwards, D., Counsell, S., Batalle, D. & Nosarti, C., 24 Oct 2022, In: Journal of Autism and Developmental Disorders.Research output: Contribution to journal › Article › peer-review
In-unit neonatal magnetic resonance imaging—new possibilities offered by low-field technology
Cawley, P. A., Nosarti, C. & Edwards, A. D., Jul 2022, In: Journal of Perinatology. 42, 7, p. 843-844 2 p.Research output: Contribution to journal › Editorial › peer-review
In-Vivo T1 Mapping of Neonatal Brain Tissue at 64mT
Padormo, F., Cawley, P., Dillon, L., Hughes, E., Almalbis, J., Robinson, J., Maggioni, A., De la Fuente Botella, M., Cromb, D., Price, A., Arlinghaus, L., Pitts, J., Luo, T., Zhang, D., Deoni, S. C. L., Williams, S., Malik, S., O'Muircheartaigh, J., Counsell, S. & Rutherford, M. & 3 others, Arichi, T., Edwards, D. & Hajnal, J., 11 Oct 2022, (Accepted/In press) In: Magnetic resonance in medicine.Research output: Contribution to journal › Article › peer-review
Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development
Lautarescu, A., Bonthrone, A., Pietsch, M., Batalle, D., Cordero-Grande, L., Tournier, J.-D., Christiaens, D., Hajnal, J., Chew, A., Falconer, S., Nosarti, C., Victor, S., Craig, M. C., Edwards, D. & Counsell, S., 9 Aug 2022, (E-pub ahead of print) In: Translational psychiatry. 323 .Research output: Contribution to journal › Article › peer-review
Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity
Yates, A. G., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A. L., Goikolea-Vives, A., Cai, V., Alkhader, L. F., Skaland, A., Hammond, B., Dimitrova, R., Batalle, D., Fernandes, C., Edwards, A. D., Gressens, P., Thornton, C. & Stolp, H. B., 29 Oct 2022, In: Journal of neuroinflammation. 19, 1, p. 265 265.Research output: Contribution to journal › Article › peer-review
Neonatal frontal-limbic connectivity is associated with externalizing behaviours in toddlers with Congenital Heart Disease
Bonthrone, A., Chew, A., Ní Bhroin, M., Morassutti Rech, F., Kelly, C., Christiaens, D., Pietsch, M., Tournier, J.-D., Cordero-Grande, L., Price, A., Egloff Collado, A., Hajnal, J., Pushparajah, K., Simpson, J., Edwards, D., Rutherford, M., Nosarti, C., Batalle, D. & Counsell, S., 17 Aug 2022, In: NeuroImage: Clinical. 36, 103153.Research output: Contribution to journal › Article › peer-review
Neonatal multi-modal cortical profiles predict 18-month developmental outcomes
Fenchel, D., Dimitrova, R., Robinson, E., Batalle, D., Chew, A., Falconer, S., Kyriakopoulou, V., Nosarti, C., Hutter, J., Christiaens, D., Pietsch, M., Brandon, J., Hughes, E., Allsop, J., O'Keeffe, C., Price, A., Cordero-Grande, L., Hajnal, J., Schuh, A. & Makropoulos , A. & 6 others, Passerat-Palmbach, J., Bozek , J., Rueckert , D., McAlonan, G., Edwards, D. & O'Muircheartaigh, J., 23 Mar 2022, (Accepted/In press) In: Developmental Cognitive Neuroscience.Research output: Contribution to journal › Article › peer-review
Postnatal maternal depressive symptoms and behavioural outcomes in term-born and preterm-born toddlers: A longitudinal UK community cohort study
Kleine, I., Vamvakas, G., Lautarescu, A., Falconer, S., Chew, A., Counsell, S., Pickles, A., Edwards, D. & Nosarti, C., 1 Sept 2022, In: BMJ Open. 12, 9, 058540.Research output: Contribution to journal › Article › peer-review
Predicting age and clinical risk from the neonatal connectome
Taoudi-Benchekroun, Y., Christiaens, D., Grigorescu, I., Gale-Grant, O., Schuh, A., Pietsch, M., Chew, A., Harper, N., Falconer, S., Poppe, T., Hughes, E., Hutter, J., Price, A., Tournier, J.-D., Cordero-Grande, L., Counsell, S., Rueckert, D., Arichi, T., Hajnal, J. & Edwards, D. & 2 others, Deprez, M. & Batalle, D., 15 Aug 2022, In: NeuroImage. 257, 119319.Research output: Contribution to journal › Article › peer-review
Publisher Correction: Brain charts for the human lifespan (Nature, (2022), 604, 7906, (525-533), 10.1038/s41586-022-04554-y)
The PREVENT-AD Research Group, VETSA, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM Team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN & POND, 13 Oct 2022, In: Nature. 610, 7931, p. E6Research output: Contribution to journal › Comment/debate › peer-review
Segmentation of Periventricular White Matter in Neonatal Brain MRI: Analysis of Brain Maturation in Term and Preterm Cohorts
Uus, A. U., Ayub, M. U., Gartner, A., Kyriakopoulou, V., Pietsch, M., Grigorescu, I., Christiaens, D., Hutter, J., Grande, L. C., Price, A., Batalle, D., Counsell, S., Hajnal, J. V., Edwards, A. D., Rutherford, M. A. & Deprez, M., 22 Sept 2022, Perinatal, Preterm and Paediatric Image Analysis - 7th International Workshop, PIPPI 2022, Held in Conjunction with MICCAI 2022, Proceedings. Licandro, R., Licandro, R., Melbourne, A., Hutter, J., Abaci Turk, E. & Macgowan, C. (eds.). Springer Science and Business Media Deutschland GmbH, p. 94-104 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 13575 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Surface Vision Transformers: Attention-Based Modelling applied to Cortical Analysis
Dahan, S., Fawaz, A., Williams, L., Yang, C., Coalson, T. S., Glasser, M. F., Edwards, D., Rueckert, D. & Robinson, E., 2022, Proceedings of Machine Learning Research. Vol. 172. p. 1-22Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Research
Wellcome EPSRC Centre for Medical Engineering
The Centre focuses on the science and engineering of medical imaging. The UK is strong in medical imaging, with the Centre hosting the largest research group in this area in Europe.The Centre combines fundamental research in engineering, physics, mathematics, computing, and chemistry with medicine and biomedical research. The 400 inter-disciplinary scientists in the Centre are transforming the diagnosis and treatment of patients, and will deliver exceptional research.
BIPP Study
The BIPP Study is a longitudinal follow-up study of brain development and childhood outcomes following very preterm birth, led by Professor Chiara Nosarti.
Project status: Ongoing
Brain Imaging in Babies (BIBS)
The Brain Imaging in Babies Study (BIBS) aims to improve understanding of how a baby's brain develops from before birth up until 3-4 years of age.
News
New eye tracking controlled VR system enhances MRI scans for young children
Researchers from King’s College London have developed new eye tracking technology which enables young children to engage in an immersive Virtual Reality (VR)...
Patterns of brain connectivity differ between preterm and term babies
A new King’s College London scanning study of 390 babies has shown distinct patterns between term and preterm babies in the dynamic (moment-to-moment)...
New Year Honours for King's staff
King's academics have been recognised in the 2024 New Year Honours list.
Professor David Edwards receives James Spence Medal
Professor David Edwards has been awarded the Royal College of Paediatrics and Child Health’s (RCPCH) highest honour, the James Spence Medal for 2023.
Professor David Edwards receives Medical School's personal tutor of the year award
Professor Edwards was cited as a source of support and encouragement for his tutees over the years
Brain charts map the rapid growth and slow decline of the human brain over our lifetime
The dHCP, a large open science project is an important part of the paper, having provided high quality, otherwise difficult to obtain brain MRIs of newborn...
Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project
Le, H., Bonthrone, A., Uus, A., Fenchel, D., Lautarescu, A., Dimitrakopoulou, K., Edwards, D., Hajnal, J., Counsell, S., Cordero-Grande, L., Christiaens, D., Batalle, D., Pietsch, M., Price, A., Patel, H., Curtis, C., Cullen, H., Deprez, M. & Tournier, J.-D., 21 Jan 2025, (Accepted/In press) In: Translational psychiatry.Research output: Contribution to journal › Article › peer-review
Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing Human Connectome Project
Le, H., Fenchel, D., Dimitrakopoulou, K., Patel, H., Curtis, C., Cordero-Grande, L., Edwards, D., Hajnal, J., Tournier, J.-D., Deprez, M. & Cullen, H., 21 Jan 2025, (Accepted/In press) In: Translational psychiatry.Research output: Contribution to journal › Article › peer-review
Cortical scaling of the neonatal brain in typical and altered development
Bonthrone, A., Cromb, D., Chew, A., Gal-Er, B., Kelly, C., Falconer, S., Arichi, T., Pushparajah, K., Simpson, J., Rutherford, M., Hajnal, J., Nosarti, C., Edwards, D., O'Muircheartaigh, J. & Counsell, S., 15 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 15, e2416423122.Research output: Contribution to journal › Article › peer-review
Gestational age at birth and cognitive outcomes in term-born children: Evidence from Chinese and British cohorts
Sun, Z., Zhang, L., Ge, Q., Xiao, C., Gale-Grant, O., Falconer, S., Chew, A., Yu, C., Edwards, A. D., Nosarti, C. & Liu, Z., May 2025, In: Early Human Development. 204, 106237.Research output: Contribution to journal › Article › peer-review
The developing Human Connectome Project fetal functional MRI release: Methods and data structures
Karolis, V. R., Cordero-Grande, L., Price, A., Hughes, E., Fitzgibbon, S., Kyriakopoulou, V., Uus, A., Harper, N., Prokopenko, D., Bridglal, D., Willers Moore, J., Wilson, S., Pietsch, M., Christiaens, D., Deprez, M., Williams, L., Robinson, E., Makropoulos, A., Farahibozorg, S.-R. & O'Muircheartaigh, J. & 7 others, Rutherford, M., Rueckert, D., Edwards, D., Arichi, T., Smith, S. M., Duff, E. P. & Hajnal, J., 6 Mar 2025, (E-pub ahead of print) In: Imaging Neuroscience. 3, 23 p.Research output: Contribution to journal › Article › peer-review
Attentional development is altered in toddlers with congenital heart disease
Bonthrone, A., Kyriakopoulou, V., Mason, L., Chew, A., Falconer, S., Kelly, C., Simpson, J., Pushparajah, K., Johnson, M. H., Edwards, D., Nosarti, C., Jones, E. J. H. & Counsell, S., 22 Apr 2024, In: JCPP Advances.Research output: Contribution to journal › Article › peer-review
Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers
Gale-Grant, O., Chew, A., Falconer, S., França, L., Fenn-Moltu, S., Hadaya, L., Harper, N., Ciarrusta Monzon, J., Charman, T., Murphy, D., Arichi, T., McAlonan, G., Nosarti, C., Edwards, D. & Batalle, D., Dec 2024, In: Scientific Reports. 14, 1, 8393.Research output: Contribution to journal › Article › peer-review
Executive function in preschool children with congenital heart disease and controls: the role of a cognitively stimulating home environment.
Chew, A., Bonthrone, A., Alford, A., Kelly, C., Pushparajah, K., Egloff, A., Hajnal, J., Simpson, J., Rutherford, M., Edwards, D., Nosarti, C. & Counsell, S., Apr 2024, In: Journal of Pediatrics. 267, 113897.Research output: Contribution to journal › Article › peer-review
Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience
Bonthrone, A., Blesa Cabez, M., Edwards, A. D., Hajnal, J. V., Counsell, S. & Boardman, J. P., 8 Dec 2024, In: Developmental Cognitive Neuroscience. 71, 101488.Research output: Contribution to journal › Article › peer-review
Individualized cortical gyrification in neonates with congenital heart disease
Cromb, D., Wilson, S., Bonthrone, A., Chew, A., Kelly, C., Kumar, M., Cawley, P., Dimitrova, R., Tournier, J.-D., Pushparajah, K., Simpson, J., Rutherford, M., Hajnal, J., Edwards, D., Nosarti, C., O'Muircheartaigh, J. & Counsell, S., 7 Oct 2024, In: Brain Communications. 6, 5, fcae356.Research output: Contribution to journal › Article › peer-review
Instant interaction driven adaptive gaze control interface
Qian, K., Arichi, T., Edwards, A. D. & Hajnal, J. V., 22 May 2024, In: Scientific Reports. 14, 1, 11661.Research output: Contribution to journal › Article › peer-review
Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment
França, L., Ciarrusta Monzon, J., Gale-Grant, O., Fenn-Moltu, S., Fitzgibbon, S. P., Chew, A., Falconer, S., Dimitrova, R., Cordero-Grande, L., Price, A., Hughes, E., O'Muircheartaigh, J., Duff, E. P., Tuulari, J. J., Deco, G., Counsell, S., Hajnal, J., Nosarti, C., Arichi, T. & Edwards, D. & 2 others, McAlonan, G. & Batalle, D., 8 Feb 2024, In: Nature Communications. 15, 1, p. 16 1 p., 16.Research output: Contribution to journal › Article › peer-review
T1 and T2 Measurements of the Neonatal Brain at 7T
Mahmoud, A., Tomi-Tricot, R., Leitão, D., Bridgen, P., Uus, A., Price, A., Lawrence, A., Cromb, D., Cawley, P. A., Deprez, M., De Vita, E., Giles, S., Rutherford, M., Edwards, D., Hajnal, J., Arichi, T. & Malik, S., 26 Nov 2024, (Accepted/In press) In: Magnetic resonance in medicine.Research output: Contribution to journal › Article › peer-review
UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings
Abate, F., Adu-Amankwah, A., Ae-Ngibise, K. A., Agbokey, F., Agyemang, V. A., Agyemang, C. T., Akgun, C., Ametepe, J., Arichi, T., Asante, K. P., Balaji, S., Baljer, L., Basser, P. J., Beauchemin, J., Bennallick, C., Berhane, Y., Boateng-Mensah, Y., Bourke, N. J., Bradford, L. & Bruchhage, M. & 92 others, Lorente, R. C., Cawley, P., Cercignani, M., D Sa, V., Canha, A. D., Navarro, N. D., Dean, D. C., Delarosa, J., Donald, K. A., Dvorak, A., Edwards, A. D., Field, D., Frail, H., Freeman, B., George, T., Gholam, J., Guerrero-Gonzalez, J., Hajnal, J. V., Haque, R., Hollander, W., Hoodbhoy, Z., Huentelman, M., Jafri, S. K., Jones, D. K., Joubert, F., Karaulanov, T., Kasaro, M. P., Knackstedt, S., Kolind, S., Koshy, B., Kravitz, R., Lafayette, S. L., Lee, A. C., Lena, B., Lepore, N., Linguraru, M., Ljungberg, E., Lockart, Z., Loth, E., Mannam, P., Masemola, K. M., Moran, R., Murphy, D., Nakwa, F. L., Nankabirwa, V., Nelson, C. A., North, K., Nyame, S., O Halloran, R., O'Muircheartaigh, J., Oakley, B. F., Odendaal, H., Ongeti, C. M., Onyango, D., Oppong, S. A., Padormo, F., Parvez, D., Paus, T., Pepper, M. S., Phiri, K. S., Poorman, M., Ringshaw, J. E., Rogers, J., Rutherford, M., Sabir, H., Sacolick, L., Seal, M., Sekoli, M. L., Shama, T., Siddiqui, K., Sindano, N., Spelke, M. B., Springer, P. E., Suleman, F. E., Sundgren, P. C., Teixeira, R., Terekegn, W., Traughber, M., Tuuli, M. G., Rensburg, J. V., Váša, F., Velaphi, S., Velasco, P., Viljoen, I. M., Vokhiwa, M., Webb, A., Weiant, C., Wiley, N., Wintermark, P., Yibetal, K., Deoni, S. & Williams, S., Oct 2024, In: Developmental Cognitive Neuroscience. 69, p. 101397 101397.Research output: Contribution to journal › Article › peer-review
560 Fetal craniofacial biometry: feasibility of deep 3D MRI phenotyping in a cohort with Down syndrome using atlas-based label propagation
Matthew, J., Uus, A., Gartner, A., Cordero-Grande, L., Kyriakopoulou, V., Cromb, D., Wright, R., O'Muircheartaigh, J., Baburamani, A., Malamateniou, C., Hutter, J., Edwards, D., Hajnal, J., Rutherford, M. & Deprez, M., 2023, British Association of Perinatal Medicine and Neonatal Society.Research output: Chapter in Book/Report/Conference proceeding › Conference paper
BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI
Uus, A. U., Kyriakopoulou, V., Makropoulos, A., Fukami-Gartner, A., Cromb, D., Davidson, A., Cordero-Grande, L., Price, A. N., Grigorescu, I., Williams, L. Z. J., Robinson, E. C., Lloyd, D., Pushparajah, K., Story, L., Hutter, J., Counsell, S. J., Edwards, A. D., Rutherford, M. A., Hajnal, J. V. & Deprez, M., 27 Apr 2023, In: bioRxiv.Research output: Contribution to journal › Article
Comparing the emotional impact of the UK COVID-19 lockdown in very preterm and full-term born children
Sun, Z., Hadaya, L., Leoni, M., Dazzan, P., Simonoff, E., Counsell, S., Edwards, D., Nosarti, C. & Vanes, L., 13 Jun 2023, In: Frontiers in Child and Adolescent Psychiatry.Research output: Contribution to journal › Article › peer-review
Development of neonatal brain functional centrality and alterations associated with preterm birth
Fenn-Moltu, S., Fitzgibbon, S. P., Ciarrusta, J., Eyre, M., Cordero-Grande, L., Chew, A., Falconer, S., Gale-Grant, O., Harper, N., Dimitrova, R., Vecchiato, K., Fenchel, D., Javed, A., Earl, M., Price, A. N., Hughes, E., Duff, E. P., O'muircheartaigh, J., Nosarti, C. & Arichi, T. & 6 others, Rueckert, D., Counsell, S., Hajnal, J. V., Edwards, A. D., Mcalonan, G. & Batalle, D., 1 May 2023, In: Cerebral Cortex. 33, 9, p. 5585-5596 12 p.Research output: Contribution to journal › Article › peer-review
Development of neonatal-specific sequences for portable ultralow field magnetic resonance brain imaging: a prospective, single-centre, cohort study
UNITY Consortium, Nov 2023, In: EClinicalMedicine. 65, p. 102253 102253.Research output: Contribution to journal › Article › peer-review
Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project
Le, H., Dimitrakopoulou, K., Patel, H., Curtis, C., Cordero-Grande, L., Edwards, D., Hajnal, J., Tournier, J.-D., Deprez, M. & Cullen, H., 10 Apr 2023, In: Translational psychiatry. 13, 1, p. 121 1 p., 121.Research output: Contribution to journal › Article › peer-review
High resolution and contrast 7 tesla MR brain imaging of the neonate
Bridgen, P., Tomi-Tricot, R., Uus, A., Cromb, D., Quirke, M., Almalbis, J., Bonse, B., De la Fuente Botella, M., Maggioni, A., Cio, P. D., Cawley, P., Casella, C., Dokumaci, A. S., Thomson, A. R., Willers Moore, J., Bridglal, D., Saravia, J., Finck, T., Price, A. N. & Pickles, E. & 12 others, Cordero-Grande, L., Egloff, A., O’Muircheartaigh, J., Counsell, S. J., Giles, S. L., Deprez, M., De Vita, E., Rutherford, M. A., Edwards, A. D., Hajnal, J. V., Malik, S. J. & Arichi, T., 2023, In: Frontiers in Radiology. 3, 1327075.Research output: Contribution to journal › Article › peer-review
Individual assessment of perioperative brain growth trajectories in infants with congenital heart disease: correlation with clinical and surgical risk factors
Cromb, D., Bonthrone, A., Maggioni, A., Cawley, P., Dimitrova, R., Kelly, C., Cordero-Grande, L., Carney, O., Egloff Collado, A., Hughes, E., Hajnal, J., Simpson, J., Pushparajah, K., Rutherford, M., Edwards, D., O'Muircheartaigh, J. & Counsell, S., 8 Jul 2023, In: Journal of the American Heart Association. 12, 14, e8599.Research output: Contribution to journal › Article › peer-review
In vivo T1 mapping of neonatal brain tissue at 64 mT
Padormo, F., Cawley, P., Dillon, L., Hughes, E., Almalbis, J., Robinson, J., Maggioni, A., Botella, M. D. L. F., Cromb, D., Price, A., Arlinghaus, L., Pitts, J., Luo, T., Zhang, D., Deoni, S. C. L., Williams, S., Malik, S., O′Muircheartaigh, J., Counsell, S. J. & Rutherford, M. & 3 others, Arichi, T., Edwards, A. D. & Hajnal, J. V., Mar 2023, In: Magnetic Resonance in Medicine. 89, 3, p. 1016-1025 10 p.Research output: Contribution to journal › Article › peer-review
Longitudinal neonatal brain development and socio-demographic correlates of infant outcomes following preterm birth
Vanes, L., Fenn-Moltu, S., Hadaya, L., Fitzgibbon, S. P., Cordero-Grande, L., Price, A., Chew, A., Falconer, S., Arichi, T., Counsell, S., Hajnal, J., Batalle, D., Edwards, D. & Nosarti, C., Jun 2023, In: Developmental Cognitive Neuroscience. 61, 101250.Research output: Contribution to journal › Article › peer-review
Maturational networks of human fetal brain activity reveal emerging connectivity patterns prior to ex-utero exposure
Karolis, V. R., Fitzgibbon, S. P., Cordero-Grande, L., Farahibozorg, S.-R., Price, A. N., Hughes, E. J., Fetit, A. E., Kyriakopoulou, V., Pietsch, M., Rutherford, M. A., Rueckert, D., Hajnal, J. V., Edwards, A. D., O'Muircheartaigh, J., Duff, E. P. & Arichi, T., 22 Jun 2023, In: Communications Biology. 6, 1, 661.Research output: Contribution to journal › Article › peer-review
Maturational networks of human fetal brain activity reveal emerging connectivity patterns prior to ex-utero exposure
Karolis, V., Fitzgibbon, S., Cordero-Grande, L., Farahibozorg, S.-R., Price, A., Hughes, E., Fetit, A. E., Kyriakopoulou, V., Pietsch, M., Rutherford, M., Rueckert, D., Hajnal, J., Edwards, D., O'Muircheartaigh, J., Duff, E. P. & Arichi, T., 2023, (Accepted/In press) In: Communications Biology.Research output: Contribution to journal › Article › peer-review
Objective assessment of visual attention in toddlerhood
Braithwaite, E., Kyriakopoulou, V., Mason, L., Davidson, A., Tusor, N., Harper, N., Earl, M., Datoo-Partridge, S., Young, A., Chew, A., Falconer, S., Hajnal, J. V., Johnson, M. H., Nosarti, C., Edwards, A. D. & Jones, E. J. H., 1 Jan 2023, In: bioRxiv. p. 2023.04.04.534573Research output: Contribution to journal › Article
Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks
Hadaya, L., Dimitrakopoulou, K., Vanes, L., Kanel, D., Fenn-Moltu, S., Gale-Grant, O., Counsell, S., Edwards, D., Saqi, M., Batalle, D. & Nosarti, C., Dec 2023, In: Translational psychiatry. 13, 1, 108.Research output: Contribution to journal › Article › peer-review
PPAR Gamma Receptor: A Novel Target to Improve Morbidity in Preterm Babies
Victor, S., Forbes, B., Greenough, A. & Edwards, D., 27 Oct 2023, In: Pharmaceuticals. 16, 11, p. 1530 11 p., 1530.Research output: Contribution to journal › Review article › peer-review
Prenatal exposure to air pollution is associated with structural changes in the neonatal brain
Bos, B., Barratt, B., Batalle, D., Gale-Grant, O., Hughes, E., Beevers, S., Cordero-Grande, L., Price, A., Hutter, J., Hajnal, J., Kelly, F., Edwards, D. & Counsell, S., 4 Apr 2023, In: Environment International.Research output: Contribution to journal › Article › peer-review
Reliability and safety of anaesthetic equipment around an high-field 7-Tesla MRI scanner
Bridgen, P., Malik, S., Wilkinson, T., Cronin, J., Bhagat, T., Hart, N., Mc Corkell, S., Perkins, J., Tibby, S., Hanna, S., Kirwan, R., Pauly, T., Weeks, A., Charles-Edwards, G., Padormo, F., Stell, D., El-Boghdadly, K., Ourselin, S., Giles, S. & Edwards, D. & 2 others, Hajnal, J. & Blaise, B. J., 19 Feb 2023, (Accepted/In press) In: British Journal of Anaesthesia.Research output: Contribution to journal › Article › peer-review
Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain
Wilson, S., Pietsch, M., Cordero-Grande, L., Christiaens, D., Uus, A., Karolis, V. R., Kyriakopoulou, V., Colford, K., Price, A. N., Hutter, J., Rutherford, M. A., Hughes, E. J., Counsell, S. J., Tournier, J.-D., Hajnal, J. V., Edwards, A. D., O'Muicheartaigh, J. & Arichi, T., 3 Apr 2023, In: eLife. 12, e83727.Research output: Contribution to journal › Article › peer-review
Structural and functional asymmetry of the neonatal cerebral cortex
Williams, L., Fitzgibbon, S., Bozek, J., Winkler, A. M., Dimitrova, R., Poppe, T., Schuh, A., Makropoulos, A., Cupitt, J., Duff, E. P., O'Muircheartaigh, J., Grande, L. C., Price, A., Hajnal, J., Rueckert, D., Smith, S. M., Edwards, D. & Robinson, E., 31 Jan 2023, (Accepted/In press) In: Nature Human Behaviour.Research output: Contribution to journal › Article › peer-review
A Deep Generative Model of Neonatal Cortical Surface Development
Fawaz, A., Williams, L. Z. J., Edwards, A. D. & Robinson, E. C., 2022, Medical Image Understanding and Analysis - 26th Annual Conference, MIUA 2022, Proceedings. Yang, G., Aviles-Rivero, A., Roberts, M. & Schönlieb, C.-B. (eds.). Springer Science and Business Media Deutschland GmbH, p. 469-481 13 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 13413 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Attention-Driven Multi-channel Deformable Registration of Structural and Microstructural Neonatal Data
Grigorescu, I., Uus, A., Christiaens, D., Cordero-Grande, L., Hutter, J., Batalle, D., Edwards, D., Hajnal, J., Modat, M. & Deprez, M., 22 Sept 2022, Lecture Notes in Computer Science. Springer, Vol. 13575.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Brain charts for the human lifespan
3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM Team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, Mayo Clinic Study of Aging, NSPN, POND, PREVENT-AD Research Group & VETSA & 1 others, Morgan, S., 21 Apr 2022, In: Nature. 604, 7906, p. 525-533 9 p.Research output: Contribution to journal › Article › peer-review
Development of functional organization within the sensorimotor network across the perinatal period
Dall'Orso, S., Arichi, T., Fitzgibbon, S. P., Edwards, D., Burdet, E. & Muceli, S., 11 Jan 2022, (Accepted/In press) In: Human Brain Mapping.Research output: Contribution to journal › Article › peer-review
Development of neonatal brain functional centrality and alterations associated with preterm birth
Fenn-Moltu, S., Fitzgibbon, S. P., Ciarrusta, J., Eyre, M., Cordero-Grande, L., Chew, A., Falconer, S., Gale-Grant, O., Harper, N., Dimitrova, R., Vecchiato, K., Fenchel, D., Javed, A., Earl, M., Price, A., Hughes, E., Duff, E. P., O'Muircheartaigh, J., Nosarti, C. & Arichi, T. & 6 others, Rueckert, D., Counsell, S., Hajnal, J., Edwards, D., McAlonan, G. & Batalle, D., 20 Nov 2022, In: Cerebral Cortex.Research output: Contribution to journal › Article › peer-review
Distinct neurodevelopmental trajectories in groups of very preterm children screening positively for autism spectrum conditions: Autism screening preterm subgroups
Hadaya, L., Vanes, L., Karolis, V. R., Kanel, D., Leoni, M., Happe, F., Edwards, D., Counsell, S., Batalle, D. & Nosarti, C., 24 Oct 2022, In: Journal of Autism and Developmental Disorders.Research output: Contribution to journal › Article › peer-review
In-unit neonatal magnetic resonance imaging—new possibilities offered by low-field technology
Cawley, P. A., Nosarti, C. & Edwards, A. D., Jul 2022, In: Journal of Perinatology. 42, 7, p. 843-844 2 p.Research output: Contribution to journal › Editorial › peer-review
In-Vivo T1 Mapping of Neonatal Brain Tissue at 64mT
Padormo, F., Cawley, P., Dillon, L., Hughes, E., Almalbis, J., Robinson, J., Maggioni, A., De la Fuente Botella, M., Cromb, D., Price, A., Arlinghaus, L., Pitts, J., Luo, T., Zhang, D., Deoni, S. C. L., Williams, S., Malik, S., O'Muircheartaigh, J., Counsell, S. & Rutherford, M. & 3 others, Arichi, T., Edwards, D. & Hajnal, J., 11 Oct 2022, (Accepted/In press) In: Magnetic resonance in medicine.Research output: Contribution to journal › Article › peer-review
Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development
Lautarescu, A., Bonthrone, A., Pietsch, M., Batalle, D., Cordero-Grande, L., Tournier, J.-D., Christiaens, D., Hajnal, J., Chew, A., Falconer, S., Nosarti, C., Victor, S., Craig, M. C., Edwards, D. & Counsell, S., 9 Aug 2022, (E-pub ahead of print) In: Translational psychiatry. 323 .Research output: Contribution to journal › Article › peer-review
Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity
Yates, A. G., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A. L., Goikolea-Vives, A., Cai, V., Alkhader, L. F., Skaland, A., Hammond, B., Dimitrova, R., Batalle, D., Fernandes, C., Edwards, A. D., Gressens, P., Thornton, C. & Stolp, H. B., 29 Oct 2022, In: Journal of neuroinflammation. 19, 1, p. 265 265.Research output: Contribution to journal › Article › peer-review
Neonatal frontal-limbic connectivity is associated with externalizing behaviours in toddlers with Congenital Heart Disease
Bonthrone, A., Chew, A., Ní Bhroin, M., Morassutti Rech, F., Kelly, C., Christiaens, D., Pietsch, M., Tournier, J.-D., Cordero-Grande, L., Price, A., Egloff Collado, A., Hajnal, J., Pushparajah, K., Simpson, J., Edwards, D., Rutherford, M., Nosarti, C., Batalle, D. & Counsell, S., 17 Aug 2022, In: NeuroImage: Clinical. 36, 103153.Research output: Contribution to journal › Article › peer-review
Neonatal multi-modal cortical profiles predict 18-month developmental outcomes
Fenchel, D., Dimitrova, R., Robinson, E., Batalle, D., Chew, A., Falconer, S., Kyriakopoulou, V., Nosarti, C., Hutter, J., Christiaens, D., Pietsch, M., Brandon, J., Hughes, E., Allsop, J., O'Keeffe, C., Price, A., Cordero-Grande, L., Hajnal, J., Schuh, A. & Makropoulos , A. & 6 others, Passerat-Palmbach, J., Bozek , J., Rueckert , D., McAlonan, G., Edwards, D. & O'Muircheartaigh, J., 23 Mar 2022, (Accepted/In press) In: Developmental Cognitive Neuroscience.Research output: Contribution to journal › Article › peer-review
Postnatal maternal depressive symptoms and behavioural outcomes in term-born and preterm-born toddlers: A longitudinal UK community cohort study
Kleine, I., Vamvakas, G., Lautarescu, A., Falconer, S., Chew, A., Counsell, S., Pickles, A., Edwards, D. & Nosarti, C., 1 Sept 2022, In: BMJ Open. 12, 9, 058540.Research output: Contribution to journal › Article › peer-review
Predicting age and clinical risk from the neonatal connectome
Taoudi-Benchekroun, Y., Christiaens, D., Grigorescu, I., Gale-Grant, O., Schuh, A., Pietsch, M., Chew, A., Harper, N., Falconer, S., Poppe, T., Hughes, E., Hutter, J., Price, A., Tournier, J.-D., Cordero-Grande, L., Counsell, S., Rueckert, D., Arichi, T., Hajnal, J. & Edwards, D. & 2 others, Deprez, M. & Batalle, D., 15 Aug 2022, In: NeuroImage. 257, 119319.Research output: Contribution to journal › Article › peer-review
Publisher Correction: Brain charts for the human lifespan (Nature, (2022), 604, 7906, (525-533), 10.1038/s41586-022-04554-y)
The PREVENT-AD Research Group, VETSA, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM Team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN & POND, 13 Oct 2022, In: Nature. 610, 7931, p. E6Research output: Contribution to journal › Comment/debate › peer-review
Segmentation of Periventricular White Matter in Neonatal Brain MRI: Analysis of Brain Maturation in Term and Preterm Cohorts
Uus, A. U., Ayub, M. U., Gartner, A., Kyriakopoulou, V., Pietsch, M., Grigorescu, I., Christiaens, D., Hutter, J., Grande, L. C., Price, A., Batalle, D., Counsell, S., Hajnal, J. V., Edwards, A. D., Rutherford, M. A. & Deprez, M., 22 Sept 2022, Perinatal, Preterm and Paediatric Image Analysis - 7th International Workshop, PIPPI 2022, Held in Conjunction with MICCAI 2022, Proceedings. Licandro, R., Licandro, R., Melbourne, A., Hutter, J., Abaci Turk, E. & Macgowan, C. (eds.). Springer Science and Business Media Deutschland GmbH, p. 94-104 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 13575 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Surface Vision Transformers: Attention-Based Modelling applied to Cortical Analysis
Dahan, S., Fawaz, A., Williams, L., Yang, C., Coalson, T. S., Glasser, M. F., Edwards, D., Rueckert, D. & Robinson, E., 2022, Proceedings of Machine Learning Research. Vol. 172. p. 1-22Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
Research
Wellcome EPSRC Centre for Medical Engineering
The Centre focuses on the science and engineering of medical imaging. The UK is strong in medical imaging, with the Centre hosting the largest research group in this area in Europe.The Centre combines fundamental research in engineering, physics, mathematics, computing, and chemistry with medicine and biomedical research. The 400 inter-disciplinary scientists in the Centre are transforming the diagnosis and treatment of patients, and will deliver exceptional research.
BIPP Study
The BIPP Study is a longitudinal follow-up study of brain development and childhood outcomes following very preterm birth, led by Professor Chiara Nosarti.
Project status: Ongoing
Brain Imaging in Babies (BIBS)
The Brain Imaging in Babies Study (BIBS) aims to improve understanding of how a baby's brain develops from before birth up until 3-4 years of age.
News
New eye tracking controlled VR system enhances MRI scans for young children
Researchers from King’s College London have developed new eye tracking technology which enables young children to engage in an immersive Virtual Reality (VR)...
Patterns of brain connectivity differ between preterm and term babies
A new King’s College London scanning study of 390 babies has shown distinct patterns between term and preterm babies in the dynamic (moment-to-moment)...
New Year Honours for King's staff
King's academics have been recognised in the 2024 New Year Honours list.
Professor David Edwards receives James Spence Medal
Professor David Edwards has been awarded the Royal College of Paediatrics and Child Health’s (RCPCH) highest honour, the James Spence Medal for 2023.
Professor David Edwards receives Medical School's personal tutor of the year award
Professor Edwards was cited as a source of support and encouragement for his tutees over the years
Brain charts map the rapid growth and slow decline of the human brain over our lifetime
The dHCP, a large open science project is an important part of the paper, having provided high quality, otherwise difficult to obtain brain MRIs of newborn...