Dr Alan Ramsay
Reader (Associate Professor) in Lymphoma Biology
Research interests
- Cancer
- Immunology
Contact details
Biography
Dr Alan Ramsay is a Reader (Associate Professor) in Lymphoma Biology within the Comprehensive Cancer Centre. He leads a research group focusing on translational research in cancer immunology. His research in the chronic lymphocytic leukaemia (CLL) and lymphoma field has characterised novel tumour cell-induced T-cell immune evasion mechanisms and translated bench science to clinical trials with immunotherapy (Ramsay et al JCI 2008)(Shanafelt and Ramsay et al Blood 2013)(Ramsay Br. J Haematol. 2013).
This work includes pre-clinical definition of CLL (Ramsay et al Blood 2012) and lymphoma (Ramsay et al Blood 2009) tumour cells co-opting multiple immune checkpoint (IC) molecules to suppress T-cell lytic immune synapse function ('adaptive immune resistance').
Current research focus: understanding and overcoming ‘microenvironmental immunosuppression’ in order to identify new targets for repairing anti-tumour immunity.
Research
Lymphoma Immunology
The Lymphoma Immunology research group is led by Dr Alan G. Ramsay, Senior PI/Associate Professor at King's College London.
Cancer Immunology & Immunotherapy
Cancer Immunology represents a broad field of research that studies host-tumour interactions as therapeutic targets in the treatment of cancer.
Project status: Ongoing
News
Drug mechanism opens door for new anti-cancer immunotherapies
Researchers have revealed a new mechanism of targeted drug treatment used against chronic lymphocytic leukaemia, through the promotion of immune cell...
Targeting the tumour environment could improve immunotherapy responses for lymphoma patients, study reveals
Researchers have shown how the cancer lymphoma reprogrammes cells key to our immune responses, leading them to shift to immunosuppressive activity
Researchers identify a combination therapy approach to help cold tumours respond to immunotherapy
The discovery marks an important step for patients with chronic lymphocytic leukemia.
Research
Lymphoma Immunology
The Lymphoma Immunology research group is led by Dr Alan G. Ramsay, Senior PI/Associate Professor at King's College London.
Cancer Immunology & Immunotherapy
Cancer Immunology represents a broad field of research that studies host-tumour interactions as therapeutic targets in the treatment of cancer.
Project status: Ongoing
News
Drug mechanism opens door for new anti-cancer immunotherapies
Researchers have revealed a new mechanism of targeted drug treatment used against chronic lymphocytic leukaemia, through the promotion of immune cell...
Targeting the tumour environment could improve immunotherapy responses for lymphoma patients, study reveals
Researchers have shown how the cancer lymphoma reprogrammes cells key to our immune responses, leading them to shift to immunosuppressive activity
Researchers identify a combination therapy approach to help cold tumours respond to immunotherapy
The discovery marks an important step for patients with chronic lymphocytic leukemia.