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Alan  Ramsay

Dr Alan Ramsay

Reader (Associate Professor) in Lymphoma Biology

Research interests

  • Cancer
  • Immunology

Contact details

Biography

Dr Alan Ramsay is a Reader (Associate Professor) in Lymphoma Biology within the Comprehensive Cancer Centre. He leads a research group focusing on translational research in cancer immunology. His research in the chronic lymphocytic leukaemia (CLL) and lymphoma field has characterised novel tumour cell-induced T-cell immune evasion mechanisms and translated bench science to clinical trials with immunotherapy (Ramsay et al JCI 2008)(Shanafelt and Ramsay et al Blood 2013)(Ramsay Br. J Haematol. 2013).

This work includes pre-clinical definition of CLL (Ramsay et al Blood 2012) and lymphoma (Ramsay et al Blood 2009) tumour cells co-opting multiple immune checkpoint (IC) molecules to suppress T-cell lytic immune synapse function ('adaptive immune resistance').

Current research focus: understanding and overcoming ‘microenvironmental immunosuppression’ in order to identify new targets for repairing anti-tumour immunity.

    Research

    lymphoma group banner
    Lymphoma Immunology

    The Lymphoma Immunology research group is led by Dr Alan G. Ramsay, Senior PI/Associate Professor at King's College London.

    Immunology and Immunotherapy Programme Header
    Cancer Immunology & Immunotherapy

    Cancer Immunology represents a broad field of research that studies host-tumour interactions as therapeutic targets in the treatment of cancer.

    Project status: Ongoing

    News

    Drug mechanism opens door for new anti-cancer immunotherapies

    Researchers have revealed a new mechanism of targeted drug treatment used against chronic lymphocytic leukaemia, through the promotion of immune cell...

    t cells

    Targeting the tumour environment could improve immunotherapy responses for lymphoma patients, study reveals

    Researchers have shown how the cancer lymphoma reprogrammes cells key to our immune responses, leading them to shift to immunosuppressive activity

    Lymphoma picture

    Researchers identify a combination therapy approach to help cold tumours respond to immunotherapy

    The discovery marks an important step for patients with chronic lymphocytic leukemia.

    cold tumours

      Research

      lymphoma group banner
      Lymphoma Immunology

      The Lymphoma Immunology research group is led by Dr Alan G. Ramsay, Senior PI/Associate Professor at King's College London.

      Immunology and Immunotherapy Programme Header
      Cancer Immunology & Immunotherapy

      Cancer Immunology represents a broad field of research that studies host-tumour interactions as therapeutic targets in the treatment of cancer.

      Project status: Ongoing

      News

      Drug mechanism opens door for new anti-cancer immunotherapies

      Researchers have revealed a new mechanism of targeted drug treatment used against chronic lymphocytic leukaemia, through the promotion of immune cell...

      t cells

      Targeting the tumour environment could improve immunotherapy responses for lymphoma patients, study reveals

      Researchers have shown how the cancer lymphoma reprogrammes cells key to our immune responses, leading them to shift to immunosuppressive activity

      Lymphoma picture

      Researchers identify a combination therapy approach to help cold tumours respond to immunotherapy

      The discovery marks an important step for patients with chronic lymphocytic leukemia.

      cold tumours