Skip to main content

King’s People

Dr Alan Ramsay

Academics

Senior Lecturer in Lymphoma Biology

Contact details

alan.ramsay@kcl.ac.uk

Biography

Dr Alan Ramsay is a Senior Lecturer in Lymphoma Biology within the Comprehensive Cancer Centre. He leads a research group focusing on translational research in cancer immunology. His research in the chronic lymphocytic leukaemia (CLL) and lymphoma field has characterised novel tumour cell-induced T-cell immune evasion mechanisms and translated bench science to clinical trials with immunotherapy (Ramsay et al JCI 2008)(Shanafelt and Ramsay et al Blood 2013)(Ramsay Br. J Haematol. 2013).

This work includes pre-clinical definition of CLL (Ramsay et al Blood 2012) and lymphoma (Ramsay et al Blood 2009) tumour cells co-opting multiple immune checkpoint (IC) molecules to suppress T-cell lytic immune synapse function ('adaptive immune resistance').

Current research focus: understanding and overcoming ‘microenvironmental immunosuppression’ in order to identify new targets for repairing anti-tumour immunity.

Latest publications

Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy
Ioannou, N., Hagner, P. R., Stokes, M., Gandhi, A. K., Apollonio, B., Fanous, M., Papazoglou, D., Sutton, L. A., Rosenquist, R., Amini, R-M., Chiu, H., Lopez-Girona, A., Janardhanan, P., Awan, F. T., Jones, J. A., Kay, N. E., Shanafelt, T. D., Tallman, M. S., Stamatopoulos, K., Patten, P. & 2 others, Vardi, A. & Ramsay, A. G., 6 Oct 2020, In : Blood. 0, 0 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1182/blood.2020006073
T-Cell Dynamics in Chronic Lymphocytic Leukemia under Different Treatment Modalities
Vardi, A., Vlachonikola, E., Papazoglou, D., Psomopoulos, F., Kotta, K., Ioannou, N., Galigalidou, C., Gemenetzi, K., Pasentsis, K., Kotouza, M., Koravou, E., ScarfÃ², L., Iskas, M., Stavroyianni, N., Ghia, P., Anagnostopoulos, A., Kouvatsi, A., Ramsay, A. G., Stamatopoulos, K. & Chatzidimitriou, A., 30 Sep 2020, In : Clinical Cancer Research. 26, 18, p. 4958-4969 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1158/1078-0432.CCR-19-3827
Combination lenalidomide-rituximab immunotherapy activates anti-tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma
Chiu, H., Preeti, T., Bjorkland, C., Soraya, C., Torano, E., Guarinos, C., Papazoglou, D., Hagner, P., Beldi-Ferchiou, A., Tarte, K., Delfau-Larue, M-H., Morschhauser, F., Ramsay, A. G. & Gandhi, A. K., Apr 2019, In : British Journal of Haematology. 185, 2, p. 240-253 14 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/bjh.15797
Combination targeted therapy in chronic lymphocytic leukaemia - can pre-clinical studies translate to the clinic?
Ioannou, N. & Ramsay, A. G., 16 May 2018, In : British Journal of Haematology. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/bjh.15279
miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function
Lim, S. P., Ioannou, N., Ramsay, A. G., Darling, D., GÃ¤ken, J. & Mufti, G. J., 1 May 2018, In : Journal of Leukocyte Biology. 103, 5, p. 855-866 12 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1002/JLB.1A0817-325RR
Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity
Hagner, P. R., Chiu, H., Ortiz, M., Apollonio, B., Wang, M., Couto, S., Waldman, M. F., Flynt, E., Ramsay, A. G., Trotter, M., Gandhi, A. K., Chopra, R. & Thakurta, A., Nov 2017, In : British Journal of Haematology. 179, 3, p. 399-409 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/bjh.14866
Extracellular vesicles released by CD40/IL-4-stimulated CLL cells confer altered functional properties to CD4+ T cells
Smallwood, D. T., Apollonio, B., Willimott, S., Lezina, L., Alharthi, A., Ambrose, A. R., De Rossi, G., Ramsay, A. G. & Wagner, S. D., 28 Jul 2016, In : Blood. 128, 4, p. 542-552 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1182/blood-2015-11-682377
Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration.
Pasikowska, M., Walsby, E., Apollonio, B., Cuthill, K. M., Phillips, E. H., Coulter, E. M., Longhi, M. S., Ma, Y., Yallop, D., Barber, L. D., Patten, P., Fegan, C., Ramsay, A. G., Pepper, C., Devereux, S. & Buggins, A. G. S., 28 Jul 2016, In : Blood. 128, 4, p. 563-573 11 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1182/blood-2016-01-683128
Tumor microenvironment (TME)-driven immune suppression in B cell malignancy
Nicholas, N. S., Apollonio, B. & Ramsay, A. G., 1 Mar 2016, In : Biochimica et biophysica acta-Molecular cell research. 1863, 3, p. 471-482 12 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1016/j.bbamcr.2015.11.003
Nurse-like cells impact on disease progression in chronic lymphocytic leukemia: Letter to the editor
Boissard, F., Laurent, C., Ramsay, A. G., Quillet-mary, A., Fournié, J., Poupot, M. & Ysebaert, L., 15 Jan 2016, In : Blood Cancer Journal. 6, 1, p. e381 Research output: Contribution to journal - Letter. DOIs: https://doi.org/10.1038/bcj.2015.108

View all publications