Dr Timothy Pullen Academics Supervisors Senior Lecturer in Biochemistry Education Research subject areas Biomedical and life sciences Contact details timothy.pullen@kcl.ac.uk @pullen_tj
Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology Identification of biomarkers for glycaemic deterioration in type 2 diabetes Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study The role of long non-coding RNAs in the regulation of pancreatic beta cell identity The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice Local and regional control of calcium dynamics in the pancreatic islet The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca dynamics in adult mice Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion Pancreatic β-cell identity, glucose sensing and the control of insulin secretion ADCY5 couples glucose to insulin secretion in human islets LKB1 and AMPK differentially regulate pancreatic β-cell identity Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1) Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6 Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1β gene expression in pancreatic islet β-cells Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum Inside and outside of the trypanosome flagellum: A multifunctional organelle Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1 The yeast CDC9 gene encodes both a nuclear and a mitochondrial form of DNA ligase I View all publications