George Goodwin is a Research Fellow at the Wolfson Sensory, Pain and Regeneration Centre. His research focuses on understanding the neurobiology of arthritis pain, with the goal of identifying new drug targets for more effective analgesic therapies. His lab uses a range of approaches, including in vivo calcium imaging, electrophysiology, transgenic mouse lines, chemogenetics, behavioural assays and histology, to study sensory neurons in mouse models of rheumatoid and osteoarthritis. The current focus of his research is to define the role of silent nociceptors - specialised sensory neurons that become activated following inflammation - in arthritis pain.

Key publications

• Goodwin et al., 2025. Using in vivo calcium imaging to examine joint neuron spontaneous activity and home cage analysis to monitor activity changes in mouse models of arthritis. Arthritis Research & Therapy.
• Goodwin et al., 2024. Assessing spontaneous sensory neuron activity using in vivo calcium imaging. PAIN.
• Goodwin et al., 2024. Spontaneous activity in peripheral sensory nerves: a systematic review. PAIN.

Key collaborators 

• Dr Franziska Denk, King's College London
• Professor Jason Ivanusic, University of Melbourne