Dr. Garnett is a senior lecturer in Structural Bacteriology in the Centre for Host-Microbiome Interactions.
A major focus of his group’s research is unravelling the molecular details of host-pathogen interactions; in particular the structure and function of bacterial biofilms, secretion systems and secreted proteins that promote infection.
He gained his PhD from the Astbury Centre for Structural and Molecular Biology at the University of Leeds where he studied transcriptional regulation of L-arginine metabolism in bacteria. After his PhD he worked towards the development of new antibacterial compounds directed against peptidoglycan biosynthesis and then moved to Imperial College London, where he studied important and novel virulence mechanisms used by bacteria, fungi and protozoa.
After receiving an MRC new investigator award he moved to Queen Mary University of London to setup his research group and to study mechanisms of type II secretion in Legionella pneumophila. Since becoming a senior lecturer at King’s, current projects in his group include understanding the molecular mechanisms of biofilm formation in Escherichia coli, Pseudomonas aeruginosa and L. pneumophila, novel bacterial effectors that promote infection, secretion by L. pneumophila and Porphyromonas gingivalis secretion systems, biogenesis of outer membrane vesicles in P. gingivalis, and the redesign of bacterial proteins for new synthetic applications.