The Garnett Lab investigates molecular mechanisms that promote bacterial disease. In particular we are interested in biofilm formation and other key virulence traits that allow bacteria to establish infections and persist within the host/environment. We take a multidiscipline approach using structural biology coupled with cellular, biochemical and other biophysical techniques.

Publications
Awards
Major Research Grants
2023-2024 BBSRC 22ALERT (BB/X019101/1). A microfluidic system and confocal microscope for the molecular and mechanistic characterisation of microbial biofilms. Applicant: James Garnett (PI), 16 others (Co-PI). Amount: £542,162
2022-2025 MRC Research Grant (MR/W000814/1). Structural studies into E. coli SsIE and its role in diarrhoeal diseases. Applicant: James Garnett (PI), Vidya Darbari (Co-PI). Amount to PI: £500,000
2019-2022 MRC Research Grant (MR/R017662/1). Structural studies into novel membrane associated virulence factors of Legionella pneumophila. Applicant: James Garnett (PI). Amount to PI: £460,083
2017-2019 Academy of Medical Sciences Springboard Award (SBF002\1150). A multidisciplinary approach to identify new antibacterial targets within biofilms. Applicant: James Garnett (PI). Amount to PI: £99,924
2017-2020 Leverhulme Trust grant (RPG-2017-222). An integrated computational-experimental method to redesign protein dynamics. Applicants: Alessandro Pandini (PI), James Garnett (Co-PI). Amount to PI: £114,024
2015-2018 MRC New Investigator Research Grant (MR/M009920/10). Recognition by the type II secretion system and how it enables Legionella pneumophila to thrive. Applicant: James Garnett (PI). Amount to PI: £463,246
Publications
Awards
Major Research Grants
2023-2024 BBSRC 22ALERT (BB/X019101/1). A microfluidic system and confocal microscope for the molecular and mechanistic characterisation of microbial biofilms. Applicant: James Garnett (PI), 16 others (Co-PI). Amount: £542,162
2022-2025 MRC Research Grant (MR/W000814/1). Structural studies into E. coli SsIE and its role in diarrhoeal diseases. Applicant: James Garnett (PI), Vidya Darbari (Co-PI). Amount to PI: £500,000
2019-2022 MRC Research Grant (MR/R017662/1). Structural studies into novel membrane associated virulence factors of Legionella pneumophila. Applicant: James Garnett (PI). Amount to PI: £460,083
2017-2019 Academy of Medical Sciences Springboard Award (SBF002\1150). A multidisciplinary approach to identify new antibacterial targets within biofilms. Applicant: James Garnett (PI). Amount to PI: £99,924
2017-2020 Leverhulme Trust grant (RPG-2017-222). An integrated computational-experimental method to redesign protein dynamics. Applicants: Alessandro Pandini (PI), James Garnett (Co-PI). Amount to PI: £114,024
2015-2018 MRC New Investigator Research Grant (MR/M009920/10). Recognition by the type II secretion system and how it enables Legionella pneumophila to thrive. Applicant: James Garnett (PI). Amount to PI: £463,246
Group lead
Contact us
James Garnett
Senior Lecturer in Structural Bacteriology
Guy's Tower Wing
Guy's Hospital