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The Garnett Lab investigates molecular mechanisms that promote bacterial disease. In particular we are interested in biofilm formation and other key virulence traits that allow bacteria to establish infections and persist within the host/environment. We take a multidiscipline approach using structural biology coupled with cellular, biochemical and other biophysical techniques.

Garnett Lab

People

James Garnett

Reader in Microbial Structural Biology

Saima  Rehman

Research Associate

Beichang Zhang

PhD student

Publications

    Awards

    Major Research Grants

    2023-2024 BBSRC 22ALERT (BB/X019101/1). A microfluidic system and confocal microscope for the molecular and mechanistic characterisation of microbial biofilms. Applicant: James Garnett (PI), 16 others (Co-PI). Amount: £542,162

    2022-2025 MRC Research Grant (MR/W000814/1). Structural studies into E. coli SsIE and its role in diarrhoeal diseases. Applicant: James Garnett (PI), Vidya Darbari (Co-PI). Amount to PI: £500,000


    2019-2022 MRC Research Grant (MR/R017662/1). Structural studies into novel membrane associated virulence factors of Legionella pneumophila. Applicant: James Garnett (PI). Amount to PI: £460,083                                                                                                                                         

    2017-2019 Academy of Medical Sciences Springboard Award (SBF002\1150). A multidisciplinary approach to identify new antibacterial targets within biofilms. Applicant: James Garnett (PI). Amount to PI: £99,924

    2017-2020 Leverhulme Trust grant (RPG-2017-222). An integrated computational-experimental method to redesign protein dynamics. Applicants: Alessandro Pandini (PI), James Garnett (Co-PI). Amount to PI: £114,024                                                              

    2015-2018 MRC New Investigator Research Grant (MR/M009920/10). Recognition by the type II secretion system and how it enables Legionella pneumophila to thrive. Applicant: James Garnett (PI). Amount to PI: £463,246

    People

    James Garnett

    Reader in Microbial Structural Biology

    Saima  Rehman

    Research Associate

    Beichang Zhang

    PhD student

    Publications

      Awards

      Major Research Grants

      2023-2024 BBSRC 22ALERT (BB/X019101/1). A microfluidic system and confocal microscope for the molecular and mechanistic characterisation of microbial biofilms. Applicant: James Garnett (PI), 16 others (Co-PI). Amount: £542,162

      2022-2025 MRC Research Grant (MR/W000814/1). Structural studies into E. coli SsIE and its role in diarrhoeal diseases. Applicant: James Garnett (PI), Vidya Darbari (Co-PI). Amount to PI: £500,000


      2019-2022 MRC Research Grant (MR/R017662/1). Structural studies into novel membrane associated virulence factors of Legionella pneumophila. Applicant: James Garnett (PI). Amount to PI: £460,083                                                                                                                                         

      2017-2019 Academy of Medical Sciences Springboard Award (SBF002\1150). A multidisciplinary approach to identify new antibacterial targets within biofilms. Applicant: James Garnett (PI). Amount to PI: £99,924

      2017-2020 Leverhulme Trust grant (RPG-2017-222). An integrated computational-experimental method to redesign protein dynamics. Applicants: Alessandro Pandini (PI), James Garnett (Co-PI). Amount to PI: £114,024                                                              

      2015-2018 MRC New Investigator Research Grant (MR/M009920/10). Recognition by the type II secretion system and how it enables Legionella pneumophila to thrive. Applicant: James Garnett (PI). Amount to PI: £463,246

      Group lead

      Contact us

      James Garnett
      Senior Lecturer in Structural Bacteriology

      Guy's Tower Wing
      Guy's Hospital