Professor Kerrin Small Academics Supervisors Professor in Genomics Contact details kerrin.small@kcl.ac.uk
Higher adherence to (poly)phenol-rich diet is associated with lower CVD risk in the TwinsUK cohort Understanding the genetic complexity of puberty timing across the allele frequency spectrum Understanding the genetic complexity of puberty timing across the allele frequency spectrum Sperm sequencing reveals extensive positive selection in the male germline Somatic mutation and selection at population scale Somatic mutation and selection at epidemiological scale Sperm sequencing reveals extensive positive selection in the male germline Longitudinal association of Perfluorooctanoic Acid (PFOA) and Perfluorooctanesulphonic Acid (PFOS) exposure with lipid traits, in a healthy unselected population Quantification of heavy metal exposure in a British population cohort links total mercury levels in plasma with skin tissue-specific changes in mitochondrial-related gene expression Genetic effects on the skin methylome in healthy older twins Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits. Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults Development of a (Poly)phenol Metabolic Signature for Assessing (Poly)phenol-Rich Dietary Patterns Haematopoietic stem cell-derived immune cells have reduced X chromosome inactivation skewing in systemic lupus erythematosus Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes The trans-ancestral genomic architecture of glycemic traits The origins and functional effects of postzygotic mutations throughout the human life span Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice PPI-Induced Changes in Plasma Metabolite Levels Influence Total Hip Bone Mineral Density in a UK Cohort Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues and is heritable Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19 Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes Further evidence supporting a potential role for ADH1B in obesity Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects Current smoking and COVID-19 risk: results from a population symptom app in over 2.4 million people X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults Cell type-specific genetic regulation of gene expression across human tissues RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information Concordance for clonal hematopoiesis is limited in elderly twins TwinsUK: The UK Adult Twin Registry Update TwinsUK: The UK Adult Twin Registry Update Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x) Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus Cell-type heterogeneity in adipose tissue is associated with complex traits and reveals disease-relevant cell-specific eQTLs Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution Nuclear Genetic Regulation of the Human Mitochondrial Transcriptome Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health 06 Biological Sciences 0604 Genetics Epigenetic findings in periodontitis in UK twins: a cross sectional study Fasting and time of day independently modulate circadian rhythm relevant gene expression in adipose and skin tissue View all publications
29 October 2025 TwinsUK data helps uncover hidden mutations that could drive cancer New research using data from the TwinsUK cohort has helped reveal how naturally occurring DNA…