Dr Kerrin Small Academics Supervisors Reader in Genomics School Academic Lead, Research and Impact, School of Life Course Sciences. Contact details kerrin.small@kcl.ac.uk
PPI-induced changes in plasma metabolite levels influence total hip bone mineral density in a UK cohort Zhang, X., Adebayo, A., Wang, D., Raza, Y., Tomlinson, M., Dooley, H., Bowyer, R., Small, K., Steves, C., Spector, T., Duncan, E., Visconti, A. & Falchi, M., 26 Nov 2022, (Accepted/In press) In: Journal of Bone and Mineral Research. Research output: Contribution to journal › Article › peer-review Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans Roberts, A., Morea, A., Amar, A., Zito, A., El-Sayed Moustafa, J., Tomlinson, M., Bowyer, R., Zhang, X., Christiansen, C., de Oliveira Costeira, R. C., Steves, C., Mangino, M., Bell, J., Wong, C., Vyse, T. & Small, K., 22 Nov 2022, In: eLife. 11 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.7554/eLife.78263 ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19 El-Sayed Moustafa, J. S., Jackson, A. U., Brotman, S. M., Guan, L., Villicaña, S., Roberts, A. L., Zito, A., Bonnycastle, L., Erdos, M. R., Narisu, N., Stringham, H. M., Welch, R., Yan, T., Lakka, T., Parker, S., Tuomilehto, J., Seow, J., Graham, C., Huettner, I., Acors, S., & 16 othersKouphou, N., Wadge, S., Duncan, E. L., Steves, C. J., Doores, K. J., Malim, M. H., Collins, F. S., Pajukanta, P., Boehnke, M., Koistinen, H. A., Laakso, M., Falchi, M., Bell, J. T., Scott, L. J., Mohlke, K. L. & Small, K. S., Aug 2022, In: International Journal of Obesity. 46, 8, p. 1478-1486 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41366-022-01136-w Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution Koprulu, M., Zhao, Y., Wheeler, E., Dong, L., Rocha, N., Li, C., Griffin, J. D., Patel, S., Van De Streek, M., Glastonbury, C. A., Stewart, I. D., Day, F. R., Luan, J., Bowker, N., Wittemans, L. B. L., Kerrison, N. D., Cai, L., Lucarelli, D. M. E., Barroso, I., McCarthy, M. I., & 10 othersScott, R. A., Saudek, V., Small, K. S., Wareham, N. J., Semple, R. K., Perry, J. R. B., O'Rahilly, S., Lotta, L. A., Langenberg, C. & Savage, D. B., 1 Apr 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 4, p. 1065-1077 13 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1210/clinem/dgab877 Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes AMP-T2D-GENES Consortia, Dec 2021, In: Nature Communications. 12, 1, 3505. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-021-23556-4 Further evidence supporting a potential role for ADH1B in obesity Morales, L. D., Cromack, D. T., Tripathy, D., Fourcaudot, M., Kumar, S., Curran, J. E., Carless, M., Göring, H. H. H., Hu, S. L., Lopez-Alvarenga, J. C., Garske, K. M., Pajukanta, P., Small, K. S., Glastonbury, C. A., Das, S. K., Langefeld, C., Hanson, R. L., Hsueh, W. C., Norton, L., Arya, R., & 5 othersMummidi, S., Blangero, J., DeFronzo, R. A., Duggirala, R. & Jenkinson, C. P., Dec 2021, In: Scientific Reports. 11, 1, 1932. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41598-020-80563-z Current smoking and COVID-19 risk: results from a population symptom app in over 2.4 million people Hopkinson, N. S., Rossi, N., El-Sayed Moustafa, J., Laverty, A. A., Quint, J. K., Freidin, M., Visconti, A., Murray, B., Modat, M., Ourselin, S., Small, K., Davies, R., Wolf, J., Spector, T. D., Steves, C. J. & Falchi, M., 1 Jul 2021, In: Thorax. 76, 7, p. 714-722 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1136/thoraxjnl-2020-216422 Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects Christiansen, C., Bell, J., Small, K., Castillo Fernandez, J., El-Sayed Moustafa, J., Maddock, J., Tsai, P-C., Molokhia, M., Suderman, M., Power, C., Relton, C., Wong, A., Kuh, D., Goodman, A., Ploubidis, G. B., Hardy, R., Domingo-Relloso, A., Smith, J. A., Wei, Z., Kardia, S. L. R., & 4 othersHaack, K., Cole, S., Tellez-Plaza, M. & Navas-Acien, A., 24 Jan 2021, (Accepted/In press) In: Clinical Epigenetics . Research output: Contribution to journal › Article › peer-review Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults Zazzara, M. B., Penfold, R. S., Roberts, A. L., Lee, K. A., Dooley, H., Sudre, C. H., Welch, C., Bowyer, R. C. E., Visconti, A., Mangino, M., Freidin, M. B., El-sayed Moustafa, J. S., Small, K. S., Murray, B., Modat, M., Graham, M. S., Wolf, J., Ourselin, S., Martin, F. C., Steves, C. J., & 1 othersLochlainn, M. N., 8 Jan 2021, In: Age and Ageing. 50, 1, p. 40-48 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/ageing/afaa223 RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro Loh, N. Y., Minchin, J. E. N., Pinnick, K. E., Verma, M., Todorčević, M., Denton, N., Moustafa, J. E. S., Kemp, J. P., Gregson, C. L., Evans, D. M., Neville, M. J., Small, K. S., McCarthy, M. I., Mahajan, A., Rawls, J. F., Karpe, F. & Christodoulides, C., 1 Dec 2020, In: Nature Communications. 11, 1, 2797. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-020-16592-z View all publications
22 November 2022 Risk of cancer doubles for people with 'skewed' blood cells Scientists have discovered that people who have a ‘skewed’ pattern in their immune blood cells are…