Dr Manuel Müller Dr Manuel Müller Academics Supervisors Proleptic Reader and Sir Henry Dale Research Fellow Research subject areas Chemistry Contact details +44 (0)20 7848 6133 manuel.muller@kcl.ac.uk
Semisynthetic ‘designer’ p53 sheds light on a phosphorylation-acetylation relay Margiola, S., Gerecht, K. & Muller, M., 28 Jun 2021, In: Chemical Science. 12, 24, p. 8563-8570 8 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1039/D1SC00396H An Unusually Rapid Protein Backbone Modification Stabilizes the Essential Bacterial Enzyme MurA Mueller, M. M., Zhang, Z. T., Hansen, K. & Politis, A., 6 Oct 2020, In: Biochemistry. 59, 39, p. 3683-3695 13 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1021/acs.biochem.0c00502 Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase Jani, K. S., Jain, S. U., Ge, E. J., Diehl, K. L., Lundgren, S. M., Müller, M. M., Lewis, P. W. & Muir, T. W., 23 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 17, p. 8295-8300 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1073/pnas.1819029116 Cancer treatment goes viral: Using viral proteins to induce tumour-specific cell death Wyatt, J., Müller, M. M. & Tavassoli, M., 2019, In: Cancers. 11, 12, 1975. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.3390/cancers11121975 HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome Jenness, C., Giunta, S., Mueller, M. M., Kimura, H., Muir, T. & Funabiki, H., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. p. E876-E885 www.pnas.org/cgi/doi/10.1073/pnas.1717509115. Research output: Contribution to journal › Article › peer-review Post-Translational Modifications of Protein Backbones: Unique Functions, Mechanisms, and Challenges Mueller, M. M., 24 Oct 2017, (E-pub ahead of print) In: Biochemistry. 10.1021/acs.biochem.7b00861. Research output: Contribution to journal › Literature review › peer-review. DOIs: https://doi.org/10.1021/acs.biochem.7b00861 ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference Dann, G. P., Liszczak, G., Bagert, J. D., Mueller, M. M., Nguyen, U. TT., Wojcik, F., Brown, Z. Z., Bos, J., Pachenko, T., Pihl, R., Pollock, S. B., Diehl, K. L., Allis, C. D. & Muir, T. W., 31 Aug 2017, In: NATURE. 548, 7669, p. 607-611 Research output: Contribution to journal › Letter › peer-review. DOIs: https://doi.org/10.1038/nature23671 A two-state activation mechanism controls the histone methyltransferase Suv39h1 Müller, M., Fierz, B., Bittova, L., Liszczak, G. & Muir, T. W., Mar 2016, In: Nature Chemical Biology. 12, 3, p. 188-193 6 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/nchembio.2008 Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation Zhou, L., Holt, M. T., Ohashi, N., Zhao, A., Muller, M., Wang, B. & Muir, T. W., 2 Feb 2016, In: Nature Communications. 7, 1, 9 p., 10589. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/ncomms10589 DNA-guided establishment of nucleosome patterns within coding regions of a eukaryotic genome Beh, L. Y., Mueller, M. M., Muir, T. W., Kaplan, N. & Landweber, L. F., Nov 2015, In: Genome Research. 25, 11, p. 1727-1738 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1101/gr.188516.114 View all publications