Professor Marzia Malcangio PhD

Biography

My research is devoted to the study of the positive and negative modulation of pain transmission, with an emphasis on chronic pain. My research group is currently focusing on neuro-immune interactions in settings of chronic pain, covering a range of specific pain subtypes from neuropathic pain to cancer-induced bone pain. To date, I have published over 100 papers on pain and edited a book on synaptic plasticity in pain. In doing so, I have explained fundamental mechanisms and identified new targets in chronic pain, including protease and chemokines pathways in microglia and macrophage-mediated mechanisms. I also lead the Wolfson CARD, which groups together researchers whose work seeks to advance our understanding of sensory systems including pain, deafness, and nervous system injury, repair and regeneration.

Please see my Research Staff Profile for more detail.

Find out more about my research:

TOBeATPAIN

Key Publications:

• Simeoli et al., 2017. Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma. Nature Communications.
• Old et al., 2014. Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. Journal of Clinical Investigation.
• Clark et al., 2007. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proceedings of the National Academy of Sciences.

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Key Collaborators:

• Professor Mauro Perretti, Queen Mary University
• Dr Emanuele Sher, Eli Lilly
• Professor Ray Chaudhuri, King’s College London
• Professor Clive Ballard, Exeter University