Professor Mathias Gautel Academics Supervisors Professor of Molecular Cardiology Head of School, School of Basic & Medical Biosciences. Research subject areas Cardiovascular Contact details mathias.gautel@kcl.ac.uk +44 (0) 20 7848 6709
Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin Wang, Z., Grange, M., Pospich, S., Wagner, T., Kho, A. L., Gautel, M. & Raunser, S., 18 Feb 2022, In: Science (New York, N.Y.). 375, 6582, eabn1934. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1126/science.abn1934 Phosphorylation at Serines 157 and 161 Is Necessary for Preserving Cardiac Expression Level and Functions of Sarcomeric Z-Disc Protein Telethonin Lewis, H. R., Eminaga, S., Gautel, M. & Avkiran, M., 8 Sep 2021, In: Frontiers in Physiology. 12, 732020. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fphys.2021.732020 Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload Filomena, M. C., Yamamoto, D. L., Carullo, P., Medvedev, R., Ghisleni, A., Piroddi, N., Scellini, B., Crispino, R., D’autilia, F., Zhang, J., Felicetta, A., Nemska, S., Serio, S., Tesi, C., Catalucci, D., Linke, W. A., Polishchuk, R., Poggesi, C., Gautel, M. & Bang, M. L., Sep 2021, In: eLife. 10, e58313. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.7554/eLife.58313 Association of Left Ventricular Systolic Dysfunction among Carriers of Truncating Variants in Filamin C with Frequent Ventricular Arrhythmia and End-stage Heart Failure Akhtar, M. M., Lorenzini, M., Pavlou, M., Ochoa, J. P., O'Mahony, C., Restrepo-Cordoba, M. A., Segura-Rodriguez, D., Bermúdez-Jiménez, F., Molina, P., Cuenca, S., Ader, F., Larrañaga-Moreira, J. M., Sabater-Molina, M., Garcia-Alvarez, M. I., Arantzamendi, L. G., Truszkowska, G., Ortiz-Genga, M., Ruiz, I. S., Nielson, S. K., Rasmussen, T. B. & 24 others, Robles Mezcua, A., Alvarez-Rubio, J., Eiskjaer, H., Gautel, M., Garcia-Pinilla, J. M., Ripoll-Vera, T., Mogensen, J., Limeres Freire, J., Rodríguez-Palomares, J. F., Peña-Peña, M. L., Rangel-Sousa, D., Palomino-Doza, J., Arana Achaga, X., Bilinska, Z., Zamarreño Golvano, E., Climent, V., Peñalver, M. N., Barriales-Villa, R., Charron, P., Yotti, R., Zorio, E., Jiménez-Jáimez, J., Garcia-Pavia, P. & Elliott, P. M., Aug 2021, In: JAMA Cardiology. 6, 8, p. 891-901 11 p., 1106. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1001/jamacardio.2021.1106 Molecular Noise-Filtering in the β-adrenergic Signaling Network by Phospholamban Pentamers Koch, D., Alexandrovich, A., Funk, F., Kho, A. L., Schmitt, J. P. & Gautel, M., 27 Jul 2021, In: Cell Reports. 36, 4, p. 109448 109448. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.celrep.2021.109448 When is an obscurin variant pathogenic? The impact of Arg4344Gln and Arg4444Trp variants on protein-protein interactions and protein stability Fukuzawa, A., Koch, D., Grover, S., Rees, M. & Gautel, M., 15 Jun 2021, In: Human Molecular Genetics. 30, 12, p. 1131-1141 11 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/hmg/ddab010 Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin Sponga, A., Arolas, J. L., Schwarz, T. C., Jeffries, C. M., Chamorro, A. R., Kostan, J., Ghisleni, A., Drepper, F., Polyansky, A., de Almeida Ribeiro, E., Pedron, M., Zawadzka-Kazimierczuk, A., Mlynek, G., Peterbauer, T., Doto, P., Schreiner, C., Hollerl, E., Mateos, B., Geist, L., Faulkner, G. & 7 others, Kozminski, W., Svergun, D. I., Warscheid, B., Zagrovic, B., Gautel, M., Konrat, R. & Djinović-Carugo, K., 28 May 2021, In: Science Advances. 7, 22, eabg7653. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1126/sciadv.abg7653 The molecular basis for sarcomere organization in vertebrate skeletal muscle Wang, Z., Grange, M., Wagner, T., Kho, A. L., Gautel, M. & Raunser, S., 15 Apr 2021, In: Cell. 184, 8, p. 2135-2150.e13 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.cell.2021.02.047 Sub-diffraction error mapping for localisation microscopy images Parsons, M., Marsh, R., Costello, I., Gorey, A., Cox, S. & Gautel, M., 2021, In: Nature Communications. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-021-25812-z The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy Deneubourg, C., Ramm, M., Smith, L. J., Baron, O., Singh, K., Byrne, S. C., Duchen, M. R., Gautel, M., Eskelinen, E. L., Fanto, M. & Jungbluth, H., 2021, (Accepted/In press) In: Autophagy. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1080/15548627.2021.1943177 View all publications
18 February 2022 Scientists obtain first high-resolution 3D image of muscle protein Researchers from King’s and the Max Planck Institute visualise the structure of the muscle protein…