Andre Strydom is a specialist in the Psychiatry of Intellectual disabilities. Dr. Strydom's research has a specific focus on conditions associated with ageing in intellectual disability (ID) populations, such as Alzheimer's disease in individuals with Down Syndrome (DS). He is an expert in ageing-related issues and the cognitive phenotype(s) associated with trisomy 21.
Current projects and collaborations include the LonDownS consortium previously funded by the Wellcome Trust and currently funded by the MRC to study the development of Alzheimer's Disease in Down syndrome; other funders include the Baily Thomas Fund and the LeJeune Foundation. This work concerns detailed cognitive phenotyping of individuals with Down across the lifespan, and tracking change with ageing using MR, EEG and fNIRS neuroimaging, as well as collecting DNA, blood and cellular samples. His research includes identification of plasma biomarkers of cognitive decline including markers related to inflammation, amyloid processing, and oxidative stress. He is a founding member of the Horizon21 European clinical trial network for Alzheimer’s disease in Down syndrome.
Dr Strydom is also involved in developing and testing the efficacy of medication and complex interventions for the treatment of mental disorders in adults with intellectual disabilities and he leads the Neurodevelopmental disorders clinical trials centre (ND-CTC) in the FANS department which conducts phase II/III clinical trials for treatments of Autism, Down syndrome and other conditions.
He has been an investigator on industry sponsored trials of new drug treatment options in Down syndrome and fragile X syndrome.
- Down syndrome
- Alzheimer’s disease
- Intellectual disabilities
- LonDowns Consortium
- AIMS-2-Trials https://www.aims-2-trials.eu
- Horizon21 Consortium
- HEROES https://heroes-jpnd.eu
Expertise and Public Engagement
Chair of the Intellectual Disabilities Dementia Interest group - https://www.kcl.ac.uk/ioppn/depts/fans/research/dementia-in-intellectual-disabilities-special-interest-group-did-sig
President (in waiting) of the Trisomy 21 Research Society - https://www.t21rs.org
Executive Committee member, Society for the Study of Behavioural Phenotypes https://ssbp.org.uk/committee/
- Mental Health in Intellectual Disabilities
- Health issues associated with Down syndrome
- Neurodevelopmental disorders
Hithersay, R., Baksh, A., Carter, B. & Strydom, A., 2020, (Accepted/In press) In : Alzheimer's & dementia : the journal of the Alzheimer's Association. Research output: Contribution to journal - Article
Strydom, A., Hithersay, R., Startin, C., Thomas, M. & D'Souza, H., 1 Sep 2020, In : JAMA Network open. 3, 9, p. e2018221 Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1001/jamanetworkopen.2020.18221
LonDownS Consortium, 1 Jan 2020, (Accepted/In press) In : Molecular Psychiatry. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1038/s41380-020-0806-5
Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., Hendrix, J., Kishnani, P. S., Lai, F., Lao, P., Lemere, C., Mobley, W., Mufson, E. J., Potter, H., Zaman, S. H., Granholm, A. C. & 4 others, , 1 Jul 2020, In : Alzheimer's and Dementia. 16, 7, p. 1065-1077 13 p. Research output: Contribution to journal - Review article. DOIs: https://doi.org/10.1002/alz.12112
Hithersay, R., Startin, C. M., Hamburg, S., Mok, K. Y., Hardy, J., Fisher, E. M. C., Tybulewicz, V. L. J., Nizetic, D. & Strydom, A., Feb 2019, In : JAMA Neurology. 76, 2, p. 152-160 9 p. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1001/jamaneurol.2018.3616
PBS study group and Angela Hassiotis, 15 Apr 2020, In : BMC Psychiatry. 20, 1, 161. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1186/s12888-020-02577-1
Mengel, D., Liu, W., Glynn, R. J., Selkoe, D. J., Strydom, A., Lai, F., Rosas, H. D., Torres, A., Patsiogiannis, V., Skotko, B. & Walsh, D. M., 19 Mar 2020, In : Alzheimer's Research and Therapy. 12, 1, 27. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1186/s13195-020-00593-7
Strydom, A., Curmi, A. & McQuillin, A., 29 Oct 2018, Physical Health of Adults with Intellectual and Developmental Disabilities. Springer International Publishing Switzerland, p. 71-86 16 p. Research output: Chapter in Book/Report/Conference proceeding - Chapter. DOIs: https://doi.org/10.1007/978-3-319-90083-4_5
Strydom, A., The LonDownS Consortium, Hithersay, R. J., Startin, C. M., Hamburg, S. F., D'Souza, H. & Thomas, M., 30 Dec 2019, (Accepted/In press) In : Journal Of Neurodevelopmental Disorders. Research output: Contribution to journal - Article
Perera, B., Courtenay, K., Solomou, S., Borakati, A. & Strydom, A., 5 Dec 2019, In : Journal of Intellectual Disability Research. Research output: Contribution to journal - Article. DOIs: https://doi.org/10.1111/jir.12705