Professor Jo Spencer Academics Supervisors Professor of Experimental Medicine Research subject areas Immunology Contact details jo.spencer@kcl.ac.uk +44 (0) 20 7848 9609
The phenotype of HLA-binding B cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-γ production against purified HLA proteins Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., Aug 2022, In: Kidney International. 102, 2, p. 355-369 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2022.02.041 The phenotype of HLA-binding B-cells from sensitised renal transplant recipients correlates with clinically prognostic patterns of IFNγ production against purified HLA proteins Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., 21 Jul 2022, In: Kidney International. 102, 2, p. 355-369 Research output: Contribution to journal › Article › peer-review ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants Seow, J., Graham, C., Hallett, S., Lechmere, T., Maguire, T., Huettner, I., Cox, D., Khan, H., Pickering, S., Waters, A., Ward, C., Mant, C., Pitcher, M., Spencer, J., Fox, J., Malim, M. & Doores, K., 3 May 2022, In: Cell Reports. 39, 5, 110757. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.celrep.2022.110757 Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood Spencer, J., Siu, J., Pitcher, M., Tull, T., Velounias, R., Guesdon, W., Montorsi, L., Mahbubani, K., Ellis, R., kadolsky, U., Kleeman, M., D'Cruz, D., Saeb-Parsy, K., Bemark, M. & Pettigrew, G., 18 Mar 2022, In: Science Immunology. 7, 69, p. eabm9060 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1126/sciimmunol.abm9060 Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis Kim, S., Boehme, L., Nel, L., Casian, A., Sangle, S., Nova-Lamperti, E., Seitan, V., Spencer, J., Lavender, P., D'Cruz, D. P. & John, S., 15 Feb 2022, In: Journal of immunology (Baltimore, Md. : 1950). 208, 4, p. 807-818 12 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.4049/jimmunol.2001331 A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution Bortolomeazzi, M., Montorsi, L., Temelkovski, D., Keddar, M. R., Acha-Sagredo, A., Pitcher, M. J., Basso, G., Laghi, L., Rodriguez-Justo, M., Spencer, J. & Ciccarelli, F. D., 9 Feb 2022, In: Nature Communications. 13, 1, 1 p., 781. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-022-28470-x Disrupted Peyer’s patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus Cellone Trevelin, S., Pickering, S., Todd, K., Bishop, C., Pitcher, M., Garrido Mesa, J., Montorsi, L., Spada, F., Petrov, N., Green, A., Shankar-Hari, M., Neil, S. & Spencer, J., 27 Jan 2022, (Accepted/In press) In: Frontiers in Immunity- sub specialisation, Mucosal Immunity. Research output: Contribution to journal › Article › peer-review Immunogenomics of colorectal cancer response to checkpoint blockade: analysis of the KEYNOTE 177 trial and validation cohorts Bortolomeazzi, M., Keddar, M. R., Montorsi, L., Acha-sagredo, A., Benedetti, L., Temelkovski, D., Choi, S., Petrov, N., Todd, K., Wai, P., Kohl, J., Denner, T., Nye, E., Goldstone, R., Ward, S., Wilson, G. A., Al Bakir, M., Swanton, C., John, S., Miles, J. & 9 others, Larijani, B., Kunene, V., Fontana, E., Arkenau, H., Parker, P. J., Rodriguez-justo, M., Shiu, K., Spencer, J. & Ciccarelli, F. D., Oct 2021, In: Gastroenterology. 161, 4, p. 1179-1193 15 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1053/j.gastro.2021.06.064 Human gut-associated lymphoid tissues (GALT); diversity, structure, and function Mörbe, U. M., Jørgensen, P. B., Fenton, T. M., von Burg, N., Riis, L. B., Spencer, J. & Agace, W. W., Jul 2021, In: Mucosal Immunology. 14, 4, p. 793-802 10 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1038/s41385-021-00389-4 Quantitative assessment of NFκB transcription factor activity Hunter, T. T. J., Fear, D., Lavender, P., Spencer, J., Peakman, M. & Ibrahim, M. A. A., May 2021, In: Journal of Immunological Methods. 492, 112954. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.jim.2020.112954 View all publications
18 March 2022 Researchers find previously undetected population complexity in human lymphoid tissue B cells Deep analysis of human marginal zone B cells could improve scientists’ understanding of lupus…