
Professor Sandrine Thuret Dr. rer. nat. FHEA
Professor of Neuroscience
Research interests
- Neuroscience
Contact details
Biography
I lead the Adult Neurogenesis & Mental Health Laboratory. The central theme of the lab is adult hippocampal neurogenesis, which is implicated in memory formation and mood regulation. We investigate environmental and molecular mechanisms controlling the production of these adult-born neurons and how they impact mental health. We study neurogenesis in healthy ageing as well as in the context of diseases such as Alzheimer’s and depression. By approaching neurogenesis in health and disease, the strategy is two folds:
- Validating the neurogenic process as a target for prevention and pharmacological interventions.
- Developing neurogenesis as a biomarker of disease prediction and progression.
I am also the Co-Head of Department of Basic and Clinical Neuroscience and the Chair of King’s Research Degrees Examination Board.
Please see my Research Staff Profile for more detail
Key publications:
- Du Preez et al., 2021. The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimers Dement.
- Dias et al., 2021. Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho. Mol Psychiatry.
- de Lucia et al., 2020. Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. Commun Biol.
- Borsini et al., 2019. The role of circulatory systemic environment in predicting interferon-alpha-induced depression: The neurogenic process as a potential mechanism. Brain Behav Immun.
- Egeland et al., 2017. Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression. Transl Psychiatry.
Key collaborators:
- The European DCogPLast Consortium, EU
- Dr Tim Powell, King's College London, UK and Cornell University, USA
- Dr Yvonne Nolan, University College Cork, Ireland
- Sir Professor Simon Lovestone, University of Oxford, UK
Research

Adult Neurogenesis & Mental Health
The central theme of the lab is postnatal or adult hippocampal neurogenesis (AHN), which is implicated in memory formation and mood regulation.

Causal Analysis & Evaluation
The Causal Modelling Group comprises statisticians and methodologists at King’s College London interested in drawing causal inferences from study data.

Ageing Research at King's (ARK)
Cross faculty consortium addressing ageing and healthy longevity.
News
New Co-Heads of Department of Basic & Clinical Neuroscience
Appointment of Professor Sandrine Thuret and Professor Karl Peter Giese introduces a new collaborative leadership structure for the department.

New test could detect Alzheimer's disease 3.5 years before clinical diagnosis
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has established a blood-based test that could be...

New evidence of the relationship between diet, neurogenesis and late-life depression
New findings from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) confirm the relationship between nutrition, neuronal health, and late-life...

King's launches new Mental Health Research PhD for Health Professionals
£7.8m Wellcome Trust funded PhD Programme will deliver a new generation of health professional scientists to lead mental health research in the future.

MRC Doctoral Training Partnership in Biomedical Sciences awarded multi-million funding
The funding will be used to train the next generation of academic, healthcare, and industrial biomedical PhD researchers.

Intermittent Fasting in mice demonstrably more effective at promoting long term memory retention
Intermittent Fasting is an effective means of improving long term memory retention and generating new adult hippocampal neurons in mice

New project to investigate impact of exercise on gut microbiota and brain health in middle age
Translational collaborative grant will see King’s partner with APC Microbiome Ireland at University College Cork to provide new knowledge and decipher...

Lack of exercise and poor nutrition could increase the risk of diseases like dementia
Diet and exercise can influence the risk of cognitive decline (CD) and dementia by potentially influencing hippocampal neurogenesis (the process by which the...

Events

Research Showcase in Eating and Weight Disorders
Join us to celebrate the launch of the Centre for Research in Eating and Weight Disorders at King's College London, and discover research from the NIHR...
Research

Adult Neurogenesis & Mental Health
The central theme of the lab is postnatal or adult hippocampal neurogenesis (AHN), which is implicated in memory formation and mood regulation.

Causal Analysis & Evaluation
The Causal Modelling Group comprises statisticians and methodologists at King’s College London interested in drawing causal inferences from study data.

Ageing Research at King's (ARK)
Cross faculty consortium addressing ageing and healthy longevity.
News
New Co-Heads of Department of Basic & Clinical Neuroscience
Appointment of Professor Sandrine Thuret and Professor Karl Peter Giese introduces a new collaborative leadership structure for the department.

New test could detect Alzheimer's disease 3.5 years before clinical diagnosis
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has established a blood-based test that could be...

New evidence of the relationship between diet, neurogenesis and late-life depression
New findings from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) confirm the relationship between nutrition, neuronal health, and late-life...

King's launches new Mental Health Research PhD for Health Professionals
£7.8m Wellcome Trust funded PhD Programme will deliver a new generation of health professional scientists to lead mental health research in the future.

MRC Doctoral Training Partnership in Biomedical Sciences awarded multi-million funding
The funding will be used to train the next generation of academic, healthcare, and industrial biomedical PhD researchers.

Intermittent Fasting in mice demonstrably more effective at promoting long term memory retention
Intermittent Fasting is an effective means of improving long term memory retention and generating new adult hippocampal neurons in mice

New project to investigate impact of exercise on gut microbiota and brain health in middle age
Translational collaborative grant will see King’s partner with APC Microbiome Ireland at University College Cork to provide new knowledge and decipher...

Lack of exercise and poor nutrition could increase the risk of diseases like dementia
Diet and exercise can influence the risk of cognitive decline (CD) and dementia by potentially influencing hippocampal neurogenesis (the process by which the...

Events

Research Showcase in Eating and Weight Disorders
Join us to celebrate the launch of the Centre for Research in Eating and Weight Disorders at King's College London, and discover research from the NIHR...