Stuart Neil Professor Stuart Neil Academics Supervisors Head of Department, Infectious Diseases Professor of Virology. Research subject areas Immunology Contact details stuart.neil@kcl.ac.uk
Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages Unified metagenomic method for rapid detection of microorganisms in clinical samples Inhibition of human cytomegalovirus replication by interferon alpha can involve multiple anti-viral factors Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells Leak or Leap? Evidence and Cognition Surrounding the Origins of the SARS-CoV-2 Virus Pangolin merbecovirus gets down to (poly)basics Strain-Dependent Restriction of Human Cytomegalovirus by Zinc Finger Antiviral Proteins The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance Kcl Test: an open-source inspired asymptomatic SARS-CoV-2 surveillance programme in an academic institution A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Differential dysregulation of -TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-B pathways in infected cells The ongoing Streptococcus pyogenes (Group A Streptococcus) outbreak in London, United Kingdom in December 2022: a molecular epidemiology study. A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction Homebrew: Protocol for glassmilk-based nucleic-acid extraction for SARS-CoV-2 diagnostics Homebrew: An economical and sensitive glassmilk-based nucleic-acid extraction method for SARS-CoV-2 diagnostics Homebrew: an economical and sensitive glassmilk-based nucleic-acid extraction method for SARS-CoV-2 diagnostics Disrupted Peyer’s patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 infection early in the pandemic and the role of unidentified cases in transmission Real-world deployment of lateral flow SARS-CoV-2 antigen detection in the emergency department to provide rapid, accurate and safe diagnosis of COVID-19 Tolerance and persistence of ebola virus in primary cells from mops condylurus, a potential ebola virus reservoir TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System The origins of SARS-CoV-2: A critical review Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation Minimal impact of ZAP on lentiviral vector production and transduction efficiency Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a laboratory evaluation study More than the eye can see – shedding new light on SARS-CoV-2 Lateral Flow Device-based immunoassays Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2 Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans Sars-cov-2 is restricted by zinc finger antiviral protein despite preadaptation to the low-cpg environment in humans Translational Research in the Time of COVID-19-Dissolving Boundaries Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection Fake Science: XMRV, COVID-19, and the Toxic Legacy of Dr. Judy Mikovits Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent and -independent mechanisms) Upregulation of BST-2 by type i interferons reduces the capacity of Vpu to protect HIV-1-infected cells from NK cell responses KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef Sensitivity to BST-2 restriction correlates with Orthobunyavirus host range View all publications
19 April 2021 Academics provide research evidence to Cabinet Office COVID-19 TaskForce Researchers teach a 3-day online course on COVID-19, leading to invitation to update members of…