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The newly established CDDU ethos is to harmonise all methods used within the labs for the processing of clinical samples. This way of working will aid comparisons between patient samples and datasets and underpin interdisciplinary biomedical and health research, as well as biomarker discovery/analysis across different disease pathways.

We are built on our work during the pandemic (KCL TEST) which achieved UKAS accreditation (ISO 15189). The CDDU services include processing of respiratory samples (sputum, nasal swabs, bronchoalveolar lavage, biopsies), blood (e.g. PBMCs, flow cytometry, CyTOF), Immunohistochemistry, Immunocytochemistry, spatial profiling, cytokine/chemokine profiling, molecular assays, pathogen work, cell culture models (e.g. ALI).

The CDDU can develop bespoke in vitro disease models for viral and drug testing applications and UKAS accreditation advice.

We offer a flexible approach to users/clients, within King’s Health Partners (KHP) and external users. 

People

David Andersson

Professor of Neuroscience

Mona Bafadhel

Chair of Respiratory Medicine

Stuart Bevan

Professor of Pharmacology

Andrew Cope

Professor of Rheumatology

Julie Fox

Professor of HIV and Sexual Health

James Galloway

Professor of Rheumatology

Projects

Diagnostics-biomarkers
Developing a new biomarker for tuberculosis diagnostics.

Together with international collaborators, we are developing a new assay to differentiate patients with active and latent tuberculosis. This would be a novel and sensitive method to detect disease status from blood easily collected to better inform medical practitioners and public health.

    743x496_abstract-blood
    Developing point of care diagnostics for the detection of blood cells.

    In collaboration with Beyond Blood Diagnostics®, we are helping to test a new point of care device which has the potential to accurately measure different blood cell types for disease monitoring. Funded by UK Research and Innovation (UKRI).

    780x440 Long Covid Consensus Study
    Profile of immunoglobulins in patients with long covid compared to healthy controls

    Examination of immunoglobulins in healthy subjects with no historical symptoms typically associated with long covid in comparison to that found in long covid patients. In collaboration with Prof. Stuart Bevan

      Age relatewd asthmatics - young woman using an inhaler
      Unravelling Age-Related differences in the responses of macrophages derived from adolescent and adult asthmatics.

      In collaboration with respiratory consultant Dr Alexandra Nanzer, we are collecting blood from asthmatic subjects of varying age and investigating whether differentiated macrophages respond differently to environmental stimuli typically impacting the airways in severe asthma. Using standard molecular and protein assays we hope to identify key dysregulated immune and inflammatory pathways which are altered with age.

        Biological Reality of Ageing header
        Beyond the Eosinophil: Understanding the impact of eosinophil depletion on T2 Inflammation. (BEUTI)

        In collaboration with Prof. David Jackson, we are investigating the role and action of biologics in severe asthma. To this end, we are collecting and processing blood, sputum and airway samples (brushings, biopsies, lavage fluid).

          Awards

          • Dr. Rocio Martinez-Nunez  - King’s Health Partners (Centre for Translational Medicine Award)
          • Dr Rachel Tribe - King’s Health Partners (Centre for Translational Medicine Award)
          • Dr. Rocio Martinez-Nunez/Beyond Blood Diagnostics - UK Research and Innovation (UKRI)
          • Dr. Rocio Martinez-Nunez  - Commercial Development Fund (KCL/Wellcome).

          People

          David Andersson

          Professor of Neuroscience

          Mona Bafadhel

          Chair of Respiratory Medicine

          Stuart Bevan

          Professor of Pharmacology

          Andrew Cope

          Professor of Rheumatology

          Julie Fox

          Professor of HIV and Sexual Health

          James Galloway

          Professor of Rheumatology

          Projects

          Diagnostics-biomarkers
          Developing a new biomarker for tuberculosis diagnostics.

          Together with international collaborators, we are developing a new assay to differentiate patients with active and latent tuberculosis. This would be a novel and sensitive method to detect disease status from blood easily collected to better inform medical practitioners and public health.

            743x496_abstract-blood
            Developing point of care diagnostics for the detection of blood cells.

            In collaboration with Beyond Blood Diagnostics®, we are helping to test a new point of care device which has the potential to accurately measure different blood cell types for disease monitoring. Funded by UK Research and Innovation (UKRI).

            780x440 Long Covid Consensus Study
            Profile of immunoglobulins in patients with long covid compared to healthy controls

            Examination of immunoglobulins in healthy subjects with no historical symptoms typically associated with long covid in comparison to that found in long covid patients. In collaboration with Prof. Stuart Bevan

              Age relatewd asthmatics - young woman using an inhaler
              Unravelling Age-Related differences in the responses of macrophages derived from adolescent and adult asthmatics.

              In collaboration with respiratory consultant Dr Alexandra Nanzer, we are collecting blood from asthmatic subjects of varying age and investigating whether differentiated macrophages respond differently to environmental stimuli typically impacting the airways in severe asthma. Using standard molecular and protein assays we hope to identify key dysregulated immune and inflammatory pathways which are altered with age.

                Biological Reality of Ageing header
                Beyond the Eosinophil: Understanding the impact of eosinophil depletion on T2 Inflammation. (BEUTI)

                In collaboration with Prof. David Jackson, we are investigating the role and action of biologics in severe asthma. To this end, we are collecting and processing blood, sputum and airway samples (brushings, biopsies, lavage fluid).

                  Publications

                  Awards

                  • Dr. Rocio Martinez-Nunez  - King’s Health Partners (Centre for Translational Medicine Award)
                  • Dr Rachel Tribe - King’s Health Partners (Centre for Translational Medicine Award)
                  • Dr. Rocio Martinez-Nunez/Beyond Blood Diagnostics - UK Research and Innovation (UKRI)
                  • Dr. Rocio Martinez-Nunez  - Commercial Development Fund (KCL/Wellcome).

                  Our Partners

                  GSTT charity

                  Guy’s & St Thomas’ (GSTT) Charity

                  Logo of the St John's Institute of Dermatology

                  St John's Institute of Dermatology