Professor Timothy Tree Academics Supervisors Professor of Immune Regulation and Immunotherapy Research subject areas Immunology Contact details timothy.tree@kcl.ac.uk (0) 20 7848 9611
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes on behalf of the INNODIA consortium, Dec 2022, In: Trials. 23, 1, 414. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1186/s13063-022-06259-z Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes Liu, Y. F., Powrie, J., Arif, S., Yang, J. H. M., Williams, E., Khatri, L., Joshi, M., Lhuillier, L., Fountoulakis, N., Smith, E., Beam, C., Lorenc, A., Peakman, M. & Tree, T., 1 Apr 2022, In: Diabetes. 71, 4, p. 722-732 11 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.2337/db21-0728 The Expression of Active CD11b Monocytes in Blood and Disease Progression in Amyotrophic Lateral Sclerosis Yildiz, O., Schroth, J., Lombardi, V., Pucino, V., Bobeva, Y., Yip, P. K., Schmierer, K., Mauro, C., Tree, T., Henson, S. M. & Malaspina, A., 21 Mar 2022, In: International Journal of Molecular Sciences. 23, 6, 3370. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3390/ijms23063370 Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes Immunology of Diabetes Society T-Cell Cytometry Group, Yang, J. H. M., Ward-Hartstonge, K. A., Perry, D. J., Blanchfield, J. L., Posgai, A. L., Wiedeman, A. E., Diggins, K., Rahman, A., Tree, T. I. M., Brusko, T. M., Levings, M. K., James, E. A., Kent, S. C., Speake, C., Homann, D. & Long, S. A., 4 Mar 2022, In: European Journal of Immunology. 52, 3, p. 372-388 17 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/eji.202049067 Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study Mahil, S. K., Bechman, K., Raharja, A., Domingo-Vila, C., Baudry, D., Brown, M. A., Cope, A. P., Dasandi, T., Graham, C., Khan, H., Lechmere, T., Malim, M. H., Meynell, F., Pollock, E., Sychowska, K., Barker, J. N., Norton, S., Galloway, J. B., Doores, K. J., Tree, T. & 1 others, Smith, C. H., Jan 2022, In: The Lancet Rheumatology. 4, 1, p. e42-e52 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/S2665-9913(21)00333-7 Concordance of B- and T-cell responses to SARS-CoV-2 infection, irrespective of symptoms suggestive of COVID-19 Österdahl, M. F., Christakou, E., Hart, D., Harris, F., Shahrabi, Y., Pollock, E., Wadud, M., Spector, T. D., Brown, M. A., Seow, J., Malim, M. H., Steves, C. J., Doores, K. J., Duncan, E. L. & Tree, T., 2022, (Accepted/In press) In: Journal of Medical Virology. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/jmv.28016 Study protocol: Minimum effective low dose: Anti-human thymocyte globulin (MELD-ATG): Phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes Wilhelm-Benartzi, C. S., Miller, S. E., Bruggraber, S., Picton, D., Wilson, M., Gatley, K., Chhabra, A., Marcovecchio, M. L., Hendriks, A. E. J., Morobé, H., Chmura, P. J., Bond, S., Aschemeier-Fuchs, B., Knip, M., Tree, T., Overbergh, L., Pall, J., Arnaud, O., Haller, M. J., Nitsche, A. & 4 others, Schulte, A. M., Mathieu, C., Mander, A. & Dunger, D., 7 Dec 2021, In: BMJ Open. 11, 12, e053669. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1136/bmjopen-2021-053669 Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) Cossarizza, A., Chang, H. D., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., Bacher, P., Bari, S., Barnaba, V., Barros-Martins, J., Baumjohann, D., Beccaria, C. G., Bernardo, D., Boardman, D. A., Borger, J., Böttcher, C. & 173 others, Brockmann, L., Burns, M., Busch, D. H., Cameron, G., Cammarata, I., Cassotta, A., Chang, Y., Chirdo, F. G., Christakou, E., Čičin-Šain, L., Cook, L., Corbett, A. J., Cornelis, R., Cosmi, L., Davey, M. S., De Biasi, S., De Simone, G., del Zotto, G., Delacher, M., Di Rosa, F., Santo, J. D., Diefenbach, A., Dong, J., Dörner, T., Dress, R. J., Dutertre, C. A., Eckle, S. B. G., Eede, P., Evrard, M., Falk, C. S., Feuerer, M., Fillatreau, S., Fiz-Lopez, A., Follo, M., Foulds, G. A., Fröbel, J., Gagliani, N., Galletti, G., Gangaev, A., Garbi, N., Garrote, J. A., Geginat, J., Gherardin, N. A., Gibellini, L., Ginhoux, F., Godfrey, D. I., Gruarin, P., Haftmann, C., Hansmann, L., Harpur, C. M., Hayday, A. C., Heine, G., Hernández, D. C., Herrmann, M., Hoelsken, O., Huang, Q., Huber, S., Huber, J. E., Huehn, J., Hundemer, M., Hwang, W. Y. K., Iannacone, M., Ivison, S. M., Jäck, H. M., Jani, P. K., Keller, B., Kessler, N., Ketelaars, S., Knop, L., Knopf, J., Koay, H. F., Kobow, K., Kriegsmann, K., Kristyanto, H., Krueger, A., Kuehne, J. F., Kunze-Schumacher, H., Kvistborg, P., Kwok, I., Latorre, D., Lenz, D., Levings, M. K., Lino, A. C., Liotta, F., Long, H. M., Lugli, E., MacDonald, K. N., Maggi, L., Maini, M. K., Mair, F., Manta, C., Manz, R. A., Mashreghi, M. F., Mazzoni, A., McCluskey, J., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Monin, L., Moretta, L., Multhoff, G., Muñoz, L. E., Muñoz-Ruiz, M., Muscate, F., Natalini, A., Neumann, K., Ng, L. G., Niedobitek, A., Niemz, J., Almeida, L. N., Notarbartolo, S., Ostendorf, L., Pallett, L. J., Patel, A. A., Percin, G. I., Peruzzi, G., Pinti, M., Pockley, A. G., Pracht, K., Prinz, I., Pujol-Autonell, I., Pulvirenti, N., Quatrini, L., Quinn, K. M., Radbruch, H., Rhys, H., Rodrigo, M. B., Romagnani, C., Saggau, C., Sakaguchi, S., Sallusto, F., Sanderink, L., Sandrock, I., Schauer, C., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schober, K., Schoen, J., Schuh, W., Schüler, T., Schulz, A. R., Schulz, S., Schulze, J., Simonetti, S., Singh, J., Sitnik, K. M., Stark, R., Starossom, S., Stehle, C., Szelinski, F., Tan, L., Tarnok, A., Tornack, J., Tree, T. I. M., van Beek, J. J. P., van de Veen, W., van Gisbergen, K., Vasco, C., Verheyden, N. A., von Borstel, A., Ward-Hartstonge, K. A., Warnatz, K., Waskow, C., Wiedemann, A., Wilharm, A., Wing, J., Wirz, O., Wittner, J., Yang, J. H. M. & Yang, J., Dec 2021, In: European Journal of Immunology. 51, 12, p. 2708-3145 438 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/eji.202170126 The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate Gee, S., Chandiramani, M., Seow, J., Pollock, E., Modestini, C., Das, A., Tree, T., Doores, K., Tribe, R. & Gibbons, D., Dec 2021, In: Nature Immunology. 22, 12, p. 1490-1502 13 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41590-021-01049-2 A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes Marwaha, A. K., Chow, S., Pesenacker, A. M., Cook, L., Sun, A., Long, S. A., Yang, J. H. M., Ward-Hartstonge, K. A., Williams, E., Domingo-Vila, C., Halani, K., Harris, K. M., Tree, T. I. M., Levings, M. K., Elliott, T., Tan, R. & Dutz, J. P., 13 Nov 2021, (E-pub ahead of print) In: Immunotherapy advances. 2, 1 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/immadv/ltab022 View all publications
12 November 2021 100 years of insulin: How immunotherapy could be the future of diabetes treatment This year is the 100th anniversary of the discovery of insulin.