Professor Timothy Tree Academics Supervisors Professor of Immune Regulation and Immunotherapy Contact details timothy.tree@kcl.ac.uk (0) 20 7848 9611
Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study Mahil, S. K., Bechman, K., Raharja, A., Domingo-Vila, C., Baudry, D., Brown, M. A., Cope, A. P., Dasandi, T., Graham, C., Khan, H., Lechmere, T., Malim, M. H., Meynell, F., Pollock, E., Sychowska, K., Barker, J. N., Norton, S., Galloway, J. B., Doores, K. J., Tree, T. & 1 others, Smith, C. H., Jan 2022, In: The Lancet Rheumatology. 4, 1, p. e42-e52 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/S2665-9913(21)00333-7 Study protocol: Minimum effective low dose: Anti-human thymocyte globulin (MELD-ATG): Phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes Wilhelm-Benartzi, C. S., Miller, S. E., Bruggraber, S., Picton, D., Wilson, M., Gatley, K., Chhabra, A., Marcovecchio, M. L., Hendriks, A. E. J., Morobé, H., Chmura, P. J., Bond, S., Aschemeier-Fuchs, B., Knip, M., Tree, T., Overbergh, L., Pall, J., Arnaud, O., Haller, M. J., Nitsche, A. & 4 others, Schulte, A. M., Mathieu, C., Mander, A. & Dunger, D., 7 Dec 2021, In: BMJ Open. 11, 12, e053669. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1136/bmjopen-2021-053669 Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) Cossarizza, A., Chang, H. D., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., Bacher, P., Bari, S., Barnaba, V., Barros-Martins, J., Baumjohann, D., Beccaria, C. G., Bernardo, D., Boardman, D. A., Borger, J., Böttcher, C. & 173 others, Brockmann, L., Burns, M., Busch, D. H., Cameron, G., Cammarata, I., Cassotta, A., Chang, Y., Chirdo, F. G., Christakou, E., Čičin-Šain, L., Cook, L., Corbett, A. J., Cornelis, R., Cosmi, L., Davey, M. S., De Biasi, S., De Simone, G., del Zotto, G., Delacher, M., Di Rosa, F., Santo, J. D., Diefenbach, A., Dong, J., Dörner, T., Dress, R. J., Dutertre, C. A., Eckle, S. B. G., Eede, P., Evrard, M., Falk, C. S., Feuerer, M., Fillatreau, S., Fiz-Lopez, A., Follo, M., Foulds, G. A., Fröbel, J., Gagliani, N., Galletti, G., Gangaev, A., Garbi, N., Garrote, J. A., Geginat, J., Gherardin, N. A., Gibellini, L., Ginhoux, F., Godfrey, D. I., Gruarin, P., Haftmann, C., Hansmann, L., Harpur, C. M., Hayday, A. C., Heine, G., Hernández, D. C., Herrmann, M., Hoelsken, O., Huang, Q., Huber, S., Huber, J. E., Huehn, J., Hundemer, M., Hwang, W. Y. K., Iannacone, M., Ivison, S. M., Jäck, H. M., Jani, P. K., Keller, B., Kessler, N., Ketelaars, S., Knop, L., Knopf, J., Koay, H. F., Kobow, K., Kriegsmann, K., Kristyanto, H., Krueger, A., Kuehne, J. F., Kunze-Schumacher, H., Kvistborg, P., Kwok, I., Latorre, D., Lenz, D., Levings, M. K., Lino, A. C., Liotta, F., Long, H. M., Lugli, E., MacDonald, K. N., Maggi, L., Maini, M. K., Mair, F., Manta, C., Manz, R. A., Mashreghi, M. F., Mazzoni, A., McCluskey, J., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Monin, L., Moretta, L., Multhoff, G., Muñoz, L. E., Muñoz-Ruiz, M., Muscate, F., Natalini, A., Neumann, K., Ng, L. G., Niedobitek, A., Niemz, J., Almeida, L. N., Notarbartolo, S., Ostendorf, L., Pallett, L. J., Patel, A. A., Percin, G. I., Peruzzi, G., Pinti, M., Pockley, A. G., Pracht, K., Prinz, I., Pujol-Autonell, I., Pulvirenti, N., Quatrini, L., Quinn, K. M., Radbruch, H., Rhys, H., Rodrigo, M. B., Romagnani, C., Saggau, C., Sakaguchi, S., Sallusto, F., Sanderink, L., Sandrock, I., Schauer, C., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schober, K., Schoen, J., Schuh, W., Schüler, T., Schulz, A. R., Schulz, S., Schulze, J., Simonetti, S., Singh, J., Sitnik, K. M., Stark, R., Starossom, S., Stehle, C., Szelinski, F., Tan, L., Tarnok, A., Tornack, J., Tree, T. I. M., van Beek, J. J. P., van de Veen, W., van Gisbergen, K., Vasco, C., Verheyden, N. A., von Borstel, A., Ward-Hartstonge, K. A., Warnatz, K., Waskow, C., Wiedemann, A., Wilharm, A., Wing, J., Wirz, O., Wittner, J., Yang, J. H. M. & Yang, J., Dec 2021, In: European Journal of Immunology. 51, 12, p. 2708-3145 438 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/eji.202170126 The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate Gee, S., Chandiramani, M., Seow, J., Pollock, E., Modestini, C., Das, A., Tree, T., Doores, K., Tribe, R. & Gibbons, D., Dec 2021, In: Nature Immunology. 22, 12, p. 1490-1502 13 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41590-021-01049-2 Humoral and cellular immunity to delayed second dose of SARS-CoV-2 BNT162b2 mRNA vaccination in patients with cancer McKenzie, D. R., Muñoz-Ruiz, M., Monin, L., Alaguthurai, T., Lechmere, T., Abdul-Jawad, S., Graham, C., Pollock, E., Graham, R., Sychowska, K., Seow, J., Tremain, C., Gousis, C., Domingo-Vila, C., Cooper, J., Vidler, J., Owczarczyk, K., Swampillai, A., Kristeleit, H., Malim, M. H. & 8 others, Fields, P., Patten, P. E. M., Papa, S., North, B. V., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., 8 Nov 2021, In: CANCER CELL. 39, 11, p. 1445-1447 3 p. Research output: Contribution to journal › Letter › peer-review. DOIs: https://doi.org/10.1016/j.ccell.2021.10.003 Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): Trial protocol Gregory, J. W., Carter, K., Cheung, W. Y., Holland, G., Bowen-Morris, J., Luzio, S., Dunseath, G., Tree, T., Yang, J. H. M., Marwaha, A., Ali, M. A., Bashir, N., Hutchings, H. A., Fegan, G. W., Stenson, R., Hiles, S., Marques-Jones, S., Brown, A., Tatovic, D. & Dayan, C., 18 Oct 2021, In: BMJ Open. 11, 10, e049595. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1136/bmjopen-2021-049595 Augmented Expansion of Treg Cells From Healthy and Autoimmune Subjects via Adult Progenitor Cell Co-Culture Reading, J. L., Roobrouck, V. D., Hull, C. M., Becker, P. D., Beyens, J., Valentin-torres, A., Boardman, D., Lamperti, E. N., Stubblefield, S., Lombardi, G., Deans, R., Ting, A. E. & Tree, T., 1 Sep 2021, In: Frontiers in Immunology. 12, 716606. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2021.716606 The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study Tree, T., Sep 2021, In: The Lancet Rheumatology. 3, 9, p. e627-e637 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/S2665-9913(21)00212-5 Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2 Tree, T., 29 Jun 2021, In: Brain Communications. 3, 3 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1093/braincomms/fcab141 Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects Arif, S., Pujol-Autonell, I., Kamra, Y., Williams, E., Yusuf, N., Domingo-Vila, C., Shahrabi, Y., Pollock, E., Khatri, L., Peakman, M., Tree, T. & Lorenc, A., 25 Jun 2021, In: Frontiers in Immunology. 12, 675746. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2021.675746 View all publications
12 November 2021 100 years of insulin: How immunotherapy could be the future of diabetes treatment This year is the 100th anniversary of the discovery of insulin.