Uncovering novel host factors that regulate HIV-1 We are studying natural human variation to further understand and discover new host regulators of HIV-1 infection and replication. Subtle differences in the human population have been captured in an extensively characterised library of induced Pluripotent Stem Cells (www.hipsci.org). These cell lines display different infection phenotypes. Correlating genotypes that explain the observed extreme phenotypes in a systems approach will permit to identify HIV-1 host regulatory factor candidates. These we will then be validated and further studied in vitro models.