Our research integrates diverse techniques and approaches from cell culture, virology, molecular biology, biochemistry and bioinformatics to uncover novel innate inhibitors and dependency factors of HIV, Influenza, SARS-CoV-2, and other viruses. We also seek to understand these host factors’ mechanism of action at the cellular and molecular levels. Identifying host-viral interactions and molecular mechanisms involved permits to clarify principles that explain viral infection, replication and spread.
The balance between dependency and restriction host factors dictate cell permissivity and thus transgene expression. This knowledge will then be applied to the optimisation of vectors for gene therapy and regenerative medicine.