Genetic Analysis and Manipulation

Biological Services Unit

Biological Services is a multi-disciplinary core research facility providing services and advice to research scientists and clinicians carrying out animal research.

Access: Applicants must complete a personal license or tissue only ethical review form, and attend an induction before they can register as a user of the BSU. Contact the facility for details.
Training: Training is mandatory for all prospective licensees and Schedule 1 users, and is available in a modular form, consisting of theory and practical based learning.
Location: The BSU has six separate facilities across King's
Contact: bsucentral@kcl.ac.uk

GEEC - Genome Editing and Embryology Core

The GEEC facility provides state-of-the art support for any projects involving genome editing and has a successful track record in the creation of transgenic animals. It also provides a general mouse embryology service for the cryopreservation and re-derivation of lines.

Access: Contact the facility to discuss project requirements.
Location: New Hunt’s House, Great Maze Pond, London, SE1 1UL | Guy’s Campus
Contact: geec@kcl.ac.uk

Gene Therapy Vector Facility

The Gene Therapy Vector Facility (GTVF), Kings College London is a state-of-the-art facility established to provide end-to-end support to the scientific community in their delivery of the latest, cutting-edge gene therapies into the clinic. With a legacy dating back to 2006, the GTVF is now one of the largest suppliers of lenti- and retroviral vector material to clinical trials across Europe, and is opening a new facility dedicated to AAV vector.

Access: Contact the facility.
Location: Rayne Institute, 123 Coldharbour Lane​, London SE5 9NU
Contact: Head of Business Development Henry Pegram

Genomics and Biomarkers Facility

The IoPPN Genomics & Biomarker is a core research facility at King's, offering a range of high-throughput genomics and biobanking services from sample preparation to bioinformatics support. The facility is a CSPro certified provider of Illumina's platforms and assays for genotyping and gene expression and provides epigenetic profiling using the 450K BeadChip and immunoassays via MSD assays for cytokines and chemokines, with state-of-the-art robotics and LIMS tracking of samples. We have also established Oxford Nanopore high-throughput next-generation long reads sequencing platform, PromethION to provide whole-genome sequencing, transcriptomics and methylome sequencing.

Access: Contact the facility.
Location: NIHR BioResource Centre Maudsley, SDGP Centre, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), 16 De Crespigny Park, London SE5 8AF | Denmark Hill Campus
Contact: Email kclgenomics@kcl.ac.uk for enquiries, and sample.processing@kcl.ac.uk for sample handling and biobanking.

High-Throughput Screening Facility

The HTS facility is equipped with state-of-the-art instrumentation to perform high-throughput and high-content functional genomics screenings using a range of libraries. The platform can accommodate cell-based screenings using diverse cell models to address a wide range of biological questions.

Access: Contact the facility manager to discuss project requirements.
Location: The James Black Building, 125 Coldharbour Lane, London SE5 9NU | Denmark Hill Campus
Contact: Facility Manager Miguel Mano