Comparison of biological pathways that differ between steroid sensitive and steroid resistant asthma patients to identify novel therapeutic targets and biomarkers in difficult asthma
Research Division: Asthma, Allergy & Lung Biology
First supervisor: Professor Catherine Hawrylowicz
Second supervisor: Dr Paul Lavender
Sponsor: The Lord Leonard and Lady Estelle Wolfson Foundation
Duration: 3 years
Stipend: £17,500 per annum
Study mode: Full time
Eligibility: Home/EU students only
Application closing date: 20 January 2014
Start date: 1 April 2014
PhD project, supported by The Lord Leonard and Lady Estelle Wolfson Foundation
will be conducted within the Division of Asthma, Allergy and Lung Biology at
King’s College London. The successful applicant will undertake research to
identify biological pathways whose function differs between steroid sensitive
and steroid resistant adult asthma patients. Samples from clinically
well-defined steroid sensitive and resistant patients prior to and after
steroid treatment will be used to perform unbiased transcriptional gene arrays
to identify differentially expressed genes at baseline and following 2-weeks of
steroids. Studies to investigate the biological relevance of identified
pathways in adult and pediatric asthma patients will then be performed. The
overall aim of this work is to identify biomarkers for improved identification
of steroid resistant asthmatics, and identify novel therapeutic targets in this
important patient group. The project will require working in a collaborative
team with computer scientists, experimental researchers and clinicians.
This studentship is open to Home/EU applicants only.
This three year PhD project is funded by The Lord Leonard and Lady Estelle Wolfson Foundation and includes an annual tax free stipend of £17,500 and tuition fees at the Home/EU rate.
How to apply
Please send a CV with a covering letter outlining your interest in the project to Keren Dempsey, stating reference 13/AALB/S01.
For further information on the studentship opportunity, please contact Keren Dempsey.