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Asthma, Allergy & Lung Biology

Comparison of biological pathways that differ between steroid sensitive and steroid resistant asthma patients to identify novel therapeutic targets and biomarkers in difficult asthma

Research Division: Asthma, Allergy & Lung Biology

First supervisor: Professor Catherine Hawrylowicz

Second supervisor: Dr Paul Lavender

Sponsor: The Lord Leonard and Lady Estelle Wolfson Foundation

Duration: 3 years

Stipend: £17,500 per annum

Study mode: Full time

Eligibility: Home/EU students only

Application closing date: 20 January 2014

Start date: 1 April 2014

Reference: 13/AALB/S01

 

Project description

This PhD project, supported by The Lord Leonard and Lady Estelle Wolfson Foundation will be conducted within the Division of Asthma, Allergy and Lung Biology at King’s College London. The successful applicant will undertake research to identify biological pathways whose function differs between steroid sensitive and steroid resistant adult asthma patients. Samples from clinically well-defined steroid sensitive and resistant patients prior to and after steroid treatment will be used to perform unbiased transcriptional gene arrays to identify differentially expressed genes at baseline and following 2-weeks of steroids. Studies to investigate the biological relevance of identified pathways in adult and pediatric asthma patients will then be performed. The overall aim of this work is to identify biomarkers for improved identification of steroid resistant asthmatics, and identify novel therapeutic targets in this important patient group. The project will require working in a collaborative team with computer scientists, experimental researchers and clinicians. 

Eligibility

This studentship is open to Home/EU applicants only.

Funding

This three year PhD project is funded by The Lord Leonard and Lady Estelle Wolfson Foundation and includes an annual tax free stipend of £17,500 and tuition fees at the Home/EU rate.

How to apply

Please send a CV with a covering letter outlining your interest in the project to Keren Dempsey, stating reference 13/AALB/S01.

Contact details

For further information on the studentship opportunity, please contact Keren Dempsey.


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