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Dr Attila Csikász-Nagy


Senior Lecturer in Computational and Systems Biology

Tel: +44 (0) 20 7848 6177


  • Current:
    2012 - present: Senior Lecturer in Computational and Systems Biology, Randall Division of Cell and Molecular Biophysics and Institute of Mathematical and Molecular Biomedicine, King's College London, London, UK

    2012 - present: Group leader, Fondazione Edmund Mach, San Michele all’Adige, Italy

  • Past:
    2011-2012: Principal Investigator, The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Rovereto, Italy

    2007-2011: Researcher, The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Rovereto, Italy

    2005-2007: Assistant Professor, Molecular Network Dynamics Research Group, Budapest University of Technology and Economics, Budapest, Hungary
  • Postdoctoral:
    2004: Postdoctoral fellow, Virginia Tech, Blacksburg, VA, USA,

    2003: Junior fellow, Computational Molecular Biology focus group, Collegium Budapest, Hungary

    2000 - 2005: Postdoctoral fellow, Dept. of Agricultural Chemical Technology, Budapest University of Technology and Economics, Hungary
  • Postgraduate: PhD in Chemistry, Dept. of Agricultural Chemical Technology, Budapest University of Technology and Economics, Hungary; Awarded September 2000.
  • Undergraduate: MSc in Bioengineering, Budapest University of Technology and Economics, Hungary; Awarded September 1998


  • Csikász-Nagy A, Sato M, Carazo Salas RE. (2013) Projecting cell polarity into the next decade. Philos Trans R Soc Lond B Biol Sci. 368(1629):20130001 
  • Bajpai A, Feoktistova A, Chen JS, McCollum D, Sato M, Carazo-Salas RE, Gould KL, Csikász-Nagy A. (2013) Dynamics of SIN Asymmetry Establishment. PLOS Computational Biology 9(7):e1003147
  • Csikász-Nagy A, Escudero LM, Guillaud M, Sedwards S, Baum B, Cavaliere M. (2013) Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis. Seminars in Cancer Biology 23:293-298
  • Dodgson J, Chessel A, Yamamoto M, Vaggi F, Cox S, Rosten E, Albrecht D, Geymonat M, Csikász-Nagy A, Sato M, Carazo-Salas RE. (2013) Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control. Nature Communications 4:1834
  • Amara F, Colombo R, Cazzaniga P, Pescini D, Csikasz-Nagy A, Muzi Falconi M, Besozzi D, Plevani P, (2013) In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae. BMC Systems Biology 7:24
  • Vaggi F, Dodgson J, Bajpai A, Chessel A, Jordan F, Sato M, Carazo-Salas RE, Csikász-Nagy A. (2012) Linkers of cell polarity and cell cycle regulation in the fission yeast protein interaction network. PLoS Computational Biology 8(10): e1002732
  • Cardelli L, Csikász-Nagy A. (2012) The Cell Cycle Switch Computes Approximate Majority. Scientific Reports 2:656
  • Ferrezuelo F., Colomina N., Palmisano A., Garí E., Gallego C., Csikász-Nagy A. & Aldea M. (2012) The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation. Nature Communications 3:1012
  • Romanel A, Cardelli L, Jensen LJ, Csikász-Nagy A (2012) Transcriptional regulation is a major controller of cell cycle transition dynamics. PLoS One 7: e29716
  • Cavaliere M, Sedwards, S, Tarnita CE, Nowak MA, Csikász-Nagy A (2012) Prosperity is associated with instability in dynamical networks. J Theor Biol 299:126-138
  • Moriya H, Chino A, Kapuy O, Csikász-Nagy A, Novak B. (2011) Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico. Mol Sys Biol 7:556
  • Csikász-Nagy A, Cardelli L, Soyer OS (2011) Response dynamics of phosphorelays suggest their potential utility in cell signaling J R Soc Interface 8(57):480-8
  • Conradie R, Bruggeman FJ, Ciliberto A, Csikász-Nagy A, Novák B, Westerhoff HV, Snoep JL.(2010) Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex. FEBS J. 277(2):357-67
  • Csikász-Nagy A, Mura I.(2010) Role of mRNA gestation and senescence in noise reduction during the cell cycle. In Silico Biol. 10:0006.
  • Csikász-Nagy A. (2009) Computational Systems Biology of the Cell Cycle. Brief Bioinform. 10(4):424-34
  • Soyer OS, Kuwahara H, Csikász-Nagy A. (2009) Regulating the total level of a signaling protein can vary its dynamics in a range from switch like ultrasensitivity to adaptive responses. FEBS J. 276(12), 3290-3298 
  • Hong CI., Zámborszky J. & Csikász-Nagy A. (2009) Minimum Criteria for DNA Damage-Induced Phase Advances in Circadian Rhythms. PLoS Comput Biol. 5(5):e1000384  
  • Csikász-Nagy A., Kapuy O., Toth A., Pal C., Jensen, L.J. Uhlmann, F. Tyson, J.J. &  Novák B. (2009) Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Mol Sys Biol 5:236
  • Mura I, Csikász-Nagy A. (2008) Stochastic Petri Net extension of a yeast cell cycle model. J Theor Biol. 254(4), 850-60.
  • Csikász-Nagy A, Soyer OS. (2008) Adaptive dynamics with a single two-state protein. J R Soc Interface. Suppl 1:S41-7.
  • Lovrics A, Zsély IG, Csikász-Nagy A, Zádor J, Turányi T, et al. (2008) Analysis of a budding yeast cell cycle model using the shapes of local sensitivity functions. Int J Chem Kinet 40: 710-720.
  • Csikász-Nagy, A., Győrffy, B., Alt, W., Tyson, J.J. &  Novák, B., (2008) Spatial controls for growth zone formation during the fission yeast cell cycle. Yeast, 25: 59–69.
  • Zámborszky J., Hong CI. & Csikász-Nagy A. (2007) Computational Analysis of Mammalian Cell Division Gated by a Circadian Clock: Quantized Cell Cycles and Cell Size Control. J Biol Rhythms, 22: 542-53.
  • Novák B., Tyson JJ., Győrffy B. & Csikász-Nagy A. (2007) Irreversible cell cycle transitions due to systems-level feedback. Nat Cell Biol, 9, 724 - 728
  • Csikász-Nagy A., Kapuy O., Győrffy B., Tyson, J.J. &  Novák, B., (2007) Modeling the Septation Initiation Network (SIN) in Fission Yeast Cells. Curr Genet, 51, 245-255
  • Lovrics A., Csikász-Nagy A., Zsély I.G., Zádor J., Turányi T. & Novák B. (2006) Time scale and dimension analysis of a budding yeast cell cycle model. BMC Bioinformatics, 7, 494
  • Csikasz-Nagy A, Battogtokh D, Chen KC, Novák B & Tyson JJ. (2006) Analysis of a generic model of eukaryotic cell cycle regulation. Biophys J 90, 4361-4379
  • Chen KC, Calzone L, Csikasz-Nagy A, Cross FR, Novak B, Tyson JJ. (2004) Integrative Analysis of Cell Cycle Control in Budding Yeast. Mol Biol Cell 15, 3841-3862.
  • Tyson, J.J., Csikász-Nagy, A. & Novák, B. (2002): The Dynamics of Cell Cycle Regulation. Bioessays 24, 1095-1109
  • Sveiczer, Á., Csikász-Nagy, A. & Novák, B. (2002): Morphogenetic checkpoint in fission yeast? Yes! Microbiology 148, 2270-2271
  • Sveiczer, Á., Csikász-Nagy, A., Gyorffy, B., Tyson, J. J., Novák, B. (2000) Modeling the fission yeast cell cycle: quantized cycle times in wee1- cdc25D mutant cells. Proc Natl Acad Sci USA, 97, 7865-7870
  • Chen, KC., Csikasz-Nagy, A., Gyorffy, B., Val, J., Novak, B., & Tyson, J.J. (2000) Kinetic Analysis of a Molecular Model of the Budding Yeast Cell Cycle. Mol Biol Cell 11, 369–391
  • Novák, B., Tóth, A., Csikász-Nagy, A., Gyorffy, B., Tyson, J.J. & Nasmyth, K. (1999) Finishing the Cell Cycle. J Theor Biol 199, 223-233
  • Novák, B., Csikász-Nagy, A., Gyorffy, B., Chen, K. & Tyson, J.J. (1998) Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Biophs Chem 72, 185-200
  • Novák, B., Csikász-Nagy, A., Gyorffy, B., Nasmyth, K. & Tyson, J.J. (1998) Model Scenarios for the Evolution of the Eukaryotic Cell Cycle. Phil Trans R Soc Lond B, 353, 2063-2076






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