Dissecting the relationship between cell migration and stem cell function during ageing.
New Hunt’s House, Guy’s Campus, London
Speaker: Dr. Robert Knight, Centre for Craniofacial and Regenerative Biology, King’s College London
Host: Prof. Peter Zammit
Title: Dissecting the relationship between cell migration and stem cell function during ageing.
Abstract: Muscle stem cells (muSCs) are critical for muscle repair and homeostasis. Impaired muSC function occurs in a variety of diseases, including chronic inflammatory syndromes, and ageing. Muscle weakness and locomotion are associated with such conditions, suggesting a causal association with ineffective muSC function. We are interested in identifying factors that can enhance muSC capacity to repair muscle with the aim of evaluating their effectiveness in promoting improved muscle function in the context of ageing and disease. Using an accelerated ageing zebrafish model caused by loss of telomerase function, we have found that an impaired inflammatory response is refractory to muscle regeneration. Live cell imaging reveals MMP9 over-expression correlates with ineffective muSC responses and aberrant macrophage behaviour which we find are causative for delayed and ineffective repair process. Our analyses of cell behaviour suggests there are multiple interventions that could be applied for improving muscle homeostasis in the context of ageing through enhancing muSC function.
________________________________________________________________________________
Microsoft Teams meeting
Join: https://teams.microsoft.com/meet/341671217980303?p=k0dX1O6ukQSDh6fhpn
Meeting ID: 341 671 217 980 303
Passcode: VD9WF2gD
For organizers: Meeting options
________________________________________________________________________________
Search for another event