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Ageing Research at King's



Reduced Levels Of Anti-Ageing Hormone Klotho Predict Renal Function Decline In Type 2 Diabetes. Fountoulakis N, Maltese G, Gnudi L, Karalliedde J. Journal of Clinical Endocrinology & Metabolism. Mar 2018 10.1210/ jc.2018-00004. 

Major features of Immunesenescence, including thymic atrophy, are ameliorated by maintained high levels of physical activity in adult life. Duggal NA, Pollock RD, Lazarus NR, Harridge SDR & Lord JM. Aging Cell. Mar 8. doi: 10.1111/acel.12750. [Epub ahead of print] (2018). 

Cardiorespiratory fitness not sedentary time or moderate to vigorous physical activity, is associated with cardiometabolic risk in highly active older adultsPollock RD, Duggal NA, Lazarus NR, Lord JM & Harridge SDR. Scandinavian Journal of Medicine and Science in Sports. Feb 10. doi: 10.1111/sms.13071. (2018). 

Properties of the vastus lateralis muscle in relation to age and physiological function in highly active older individuals master cyclists aged 55- 79 years. Pollock RD, O’Brien K, Daniels L, Nielson KB, Rowlerson A, Philp, A Lazarus NR, Lord, J & Harridge SDR. Aging Cell Mar 8. doi: 10.1111/acel.12735. (2018). 
Shared genetic influence on frailty and chronic widespread pain: a study from TwinsUK, Age and Ageing* joint last authors. Livshits G, Ni Lochlainn M, Malkin I, Bowyer R, Verdi S, Steves CJ, Williams FMK. Age and Ageing. (2017).
The Identification of Hereditary and Environmental Determinants of Frailty in a Cohort of UK Twins. Young ACM, Glaser K, Spector TD, Steves CJ. Twin Res Hum Gen.19(6):600-609 (2017). 
Predictors of emergency department attendance by people with dementia in their last year of life: Retrospective cohort study using linked clinical and administrative dataSleeman KE, Perera G, Stewart R, Higginson IJ. Alzheimers Dement. pii: S1552-5260(17)32520-7. doi: 10.1016/j.jalz.2017.06.2267. (2017). 
Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort.  Dowd JB, Bosch JA, Steptoe Bamini A. Jayabalasingham B, Lin J, Yolken R, Aiello AE. The Journal of Infectious Diseases. (2017).
Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue. Boengler K, Kosiol M, Mayr M, Schulz R, Rohrbach S. J Cachexia Sarcopenia Muscle. 8(3):349-369. doi: 10.1002/ jcsm. 12178. (2017). 
Perturbations of the anti ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria. Maltese G, Fountoulakis N, Siow RC, Gnudi L, Karalliedde J. Diabetologia. 60(5):911-914. doi: 10.1007/s00125-017-4219-1. (2017). 
Performance of master athletes: silhouettes of the trajectory of healthy human ageing? Lazarus NR, Harridge SDR. J Physiol. 1595(9):2941-2948. doi: 10.1113/JP272443. (2017). 
Declining performance of master athletes: silhouettes of the trajectory of healthy human ageing?  Lazarus NR, Harridge SDR. J Physiol. 1;595(9):2941-2948. doi: 10.1113/JP272443. (2017). 
Trends in the relationship of Obesity and Disability, 1988 -2012 Chang VW, Alley DE, Dowd JB. Am J Epidemiol. doi:1093/aje/kwx092. (2017). 
Genetic predisposition to advanced biological ageing increases risk for childhood-onset recurrent major depressive disorder in a large UK sample. Michalek JE, Kepa A, Vincent J, Frissa S, Goodwin L, Hotopf M, Hatch SL, Breen G, Powell TR. J Affect Disord.213:207-213. doi: 10.1016/j.jad.2017.01.017. (2017).
Age-related changes in intraventricular kinetic energy: a physiological or pathological adaptation? 
Wong J, Chabiniok R, deVecchi A, Dedieu N, Sammut E, Schaeffter T, Razavi R. Am J Physiol Heart Circ Physiol. 15;310(6):H747-55. doi: 10.1152/ajpheart.00075.(2016)
Developing a model of short-term integrated palliative and supportive care for frail older people in community settings: perspectives of older people, carers and other key stakeholders. Bone AE, Morgan M, Maddocks M, Sleeman KE, Wright J, Taherzadeh S, Ellis-Smith C, Higginson IJ, Evans CJ. Age Ageing. 45(6):863-873.(2016). 
Measures to assess commonly experienced symptoms for people with dementia in long-term care settings: a systematic review. Ellis-Smith C, Evans CJ, Bone AE, Henson LA, Dzingina M, Kane PM, Higginson IJ, Daveson BA; BuildCARE. BMC Med. 26;14:38. doi: 10.1186/s12916-016-0582-x.(2016).
The changing demographics of inpatient hospice death: Population-based cross-sectional study in England, 1993-2012Sleeman KE, Davies JM, Verne J, Gao W, Higginson IJ.(2016). Palliat Med. 30(1):45-53. doi: 10.1177/0269216315585064. (2016)
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