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Ageing Research at King's

Publications

2018

Reduced Levels Of Anti-Ageing Hormone Klotho Predict Renal Function Decline In Type 2 Diabetes. Fountoulakis N, Maltese G, Gnudi L, Karalliedde J. Journal of Clinical Endocrinology & Metabolism. Mar 2018 doi.org/ 10.1210/ jc.2018-00004. 

Major features of Immunesenescence, including thymic atrophy, are ameliorated by maintained high levels of physical activity in adult life. Duggal NA, Pollock RD, Lazarus NR, Harridge SDR & Lord JM. Aging Cell. Mar 8. doi: 10.1111/acel.12750. [Epub ahead of print] (2018). 

Cardiorespiratory fitness not sedentary time or moderate to vigorous physical activity, is associated with cardiometabolic risk in highly active older adultsPollock RD, Duggal NA, Lazarus NR, Lord JM & Harridge SDR. Scandinavian Journal of Medicine and Science in Sports. Feb 10. doi: 10.1111/sms.13071. (2018). 

Properties of the vastus lateralis muscle in relation to age and physiological function in highly active older individuals master cyclists aged 55- 79 years. Pollock RD, O’Brien K, Daniels L, Nielson KB, Rowlerson A, Philp, A Lazarus NR, Lord, J & Harridge SDR. Aging Cell Mar 8. doi: 10.1111/acel.12735. (2018). 
2017
Shared genetic influence on frailty and chronic widespread pain: a study from TwinsUK, Age and Ageing* joint last authors. Livshits G, Ni Lochlainn M, Malkin I, Bowyer R, Verdi S, Steves CJ, Williams FMK. Age and Ageing. doi.org/10.1093 (2017).
 
The Identification of Hereditary and Environmental Determinants of Frailty in a Cohort of UK Twins. Young ACM, Glaser K, Spector TD, Steves CJ. Twin Res Hum Gen.19(6):600-609 (2017). 
 
Predictors of emergency department attendance by people with dementia in their last year of life: Retrospective cohort study using linked clinical and administrative dataSleeman KE, Perera G, Stewart R, Higginson IJ. Alzheimers Dement. pii: S1552-5260(17)32520-7. doi: 10.1016/j.jalz.2017.06.2267. (2017). 
 
Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort.  Dowd JB, Bosch JA, Steptoe Bamini A. Jayabalasingham B, Lin J, Yolken R, Aiello AE. The Journal of Infectious Diseases. doi.org/10.1093/infdis/jix255. (2017).
 
Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue. Boengler K, Kosiol M, Mayr M, Schulz R, Rohrbach S. J Cachexia Sarcopenia Muscle. 8(3):349-369. doi: 10.1002/ jcsm. 12178. (2017). 
 
Perturbations of the anti ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria. Maltese G, Fountoulakis N, Siow RC, Gnudi L, Karalliedde J. Diabetologia. 60(5):911-914. doi: 10.1007/s00125-017-4219-1. (2017). 
 
Performance of master athletes: silhouettes of the trajectory of healthy human ageing? Lazarus NR, Harridge SDR. J Physiol. 1595(9):2941-2948. doi: 10.1113/JP272443. (2017). 
 
Declining performance of master athletes: silhouettes of the trajectory of healthy human ageing?  Lazarus NR, Harridge SDR. J Physiol. 1;595(9):2941-2948. doi: 10.1113/JP272443. (2017). 
 
Trends in the relationship of Obesity and Disability, 1988 -2012 Chang VW, Alley DE, Dowd JB. Am J Epidemiol. doi:1093/aje/kwx092. (2017). 
 
Genetic predisposition to advanced biological ageing increases risk for childhood-onset recurrent major depressive disorder in a large UK sample. Michalek JE, Kepa A, Vincent J, Frissa S, Goodwin L, Hotopf M, Hatch SL, Breen G, Powell TR. J Affect Disord.213:207-213. doi: 10.1016/j.jad.2017.01.017. (2017).
2016
Age-related changes in intraventricular kinetic energy: a physiological or pathological adaptation? 
Wong J, Chabiniok R, deVecchi A, Dedieu N, Sammut E, Schaeffter T, Razavi R. Am J Physiol Heart Circ Physiol. 15;310(6):H747-55. doi: 10.1152/ajpheart.00075.(2016)
 
Developing a model of short-term integrated palliative and supportive care for frail older people in community settings: perspectives of older people, carers and other key stakeholders. Bone AE, Morgan M, Maddocks M, Sleeman KE, Wright J, Taherzadeh S, Ellis-Smith C, Higginson IJ, Evans CJ. Age Ageing. 45(6):863-873.(2016). 
 
Measures to assess commonly experienced symptoms for people with dementia in long-term care settings: a systematic review. Ellis-Smith C, Evans CJ, Bone AE, Henson LA, Dzingina M, Kane PM, Higginson IJ, Daveson BA; BuildCARE. BMC Med. 26;14:38. doi: 10.1186/s12916-016-0582-x.(2016).
 
The changing demographics of inpatient hospice death: Population-based cross-sectional study in England, 1993-2012Sleeman KE, Davies JM, Verne J, Gao W, Higginson IJ.(2016). Palliat Med. 30(1):45-53. doi: 10.1177/0269216315585064. (2016)
 
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