Iron Metabolism Group
The London Iron Metabolism Group (LIMG), founded in 1998, brings together scientists from across London who have an interest in iron and other metals. It evolved from the long standing 'Centre for the Study of Metals in Biology and Medicine’ at Queen Elizabeth College. King's College London has been the driving force over the past decade, but now the group has been expanded to include other London-based institutes. The organisation of LIMG is currently shared between KCL, UCL and Imperial College. In 2002 LIMG gained recognition by the MRC as a Cooperative Group. The group regularly organises open-access seminars, which are orientated towards all aspects of iron metabolism.
The overall aim of the group is to investigate the molecular, physiological and biochemical processes of iron metabolism in organisms and to elucidate pathophysiological mechanisms with a view to therapeutic intervention of iron-related disorders.
- to understand the genes, proteins and mechanisms involved in dietary iron and haem absorption.
- To define the genes, proteins and mechanisms of iron uptake and distribution in the brain and other organs.
- To understand the regulation of intracellular and systemic iron metabolism
- To define the influence of iron on immune cell functions.
Translational and therapeutic approaches
- Development of novel iron chelators as therapy for peripheral and CNS disorders.
- Improved understanding of the nutrition and toxicology of iron and zinc.
- The functions of iron in immunity
- Iron bioavailability from foods