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Human biomarkers for measuring niacin intake and status

Niacin can be assessed by different methods, as shown in Table 1.

Table 1. Assessment methods for niacin (1)
 Biomarker  Analysis type Sample   Benefits Intricacies 
Urinary excretion Indirect analysis Urine Reliable and sensitive Insensitive to marginal niacin intake
 Niacin Direct analysis Plasma Rapid sample preparation Only selected plasma metabolites are good indicators
 Niacin Direct analysis  RBC Sensitive to niacin depletion  

RBC: red blood cells

Quality control and technical assistance

Laboratory accreditation and validation

LabCorp (headquartered in Burlington, North Caroline, USA) is a leading global life science company. Licensure/accreditation documentation may be requested by sending an email to:

This is a paid service, with a wide number of options, e.g. vitamin B3, serum or plasma

ARUP Laboratories: A National Reference Laboratory is a US national clinical and anatomic pathology reference laboratory and a worldwide leader in innovative laboratory research and development. A non-profit enterprise of the University of Utah, ARUP offers an extensive menu of highly complex and unique medical tests.

For accreditation documentation see this page.

E.g. Vitamin B3, plasma

 For other laboratory accreditation and validation schemes, see the OpeN-Global laboratory accreditation page.

Technical assistance

For questions on riboflavin methods or for technical assistance, please or write to:

Dr Daniela Hampel, PhD
Project Scientist
USDA/ARS Western Human Nutrition Research Center
Department of Nutrition, University of California Davis

Email: or