Dr Afshan Malik Dr Afshan Malik Academics Supervisors Reader in Mitochondrial and Diabetes Research Postgraduate co-ordinator for PhD students in Diabetes . Research subject areas Diabetes Contact details afshan.malik@kcl.ac.uk @afshanmalik @DRG_Kings @Biochemkcl
Preclinical evidence for mitochondrial DNA as a potential blood biomarker for chemotherapy-induced peripheral neuropathy Trecarichi, A., Duggett, N. A., Granat, L., Lo, S., Malik, A. N., Zuliani-Álvarez, L. & Flatters, S. J. L., Jan 2022, In: PLoS ONE. 17, 1, e0262544. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1371/journal.pone.0262544 Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship Karkucinska-Wieckowska, A., Simoes, I. C. M., Kalinowski, P., Lebiedzinska-Arciszewska, M., Zieniewicz, K., Milkiewicz, P., Górska-Ponikowska, M., Pinton, P., Malik, A. N., Krawczyk, M., Oliveira, P. J. & Wieckowski, M. R., 15 Jun 2021, (E-pub ahead of print) In: European Journal of Clinical Investigation. 52, 3 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/eci.13622 Accurate Measurement of Cellular and Cell-Free Circulating Mitochondrial DNA Content from Human Blood Samples Using Real-Time Quantitative PCR Rosa, H. & Malik, A. N., 2021, Methods in Molecular Biology. Humana Press Inc, p. 247-268 22 p. (Methods in Molecular Biology; vol. 2277). Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review. DOIs: https://doi.org/10.1007/978-1-0716-1270-5_15 Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity Maragkoudaki, X., Naylor, M., Papacleovoulou, G., Stolarczyk, E., Rees, D., Pombo, J. M., Abu-Hayyeh, S., Czajka, A., Howard, J. K., Malik, A. N., Williamson, C., Poston, L. & Taylor, P. D., Dec 2020, In: International Journal of Obesity. 44, 12, p. 2382-2393 12 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41366-020-00682-5 A case for measuring both cellular and cell-free mitochondrial DNA as a disease biomarker in human blood Rosa, H. S., Ajaz, S., Gnudi, L. & Malik, A. N., 1 Sep 2020, In: Faseb Journal. 34, 9, p. 12278-12288 11 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1096/fj.202000959RR Optimizing beta cell function through mesenchymal stromal cell mediated mitochondria transfer Rackham, C. L., Hubber, E. L., Czajka, A., Malik, A. N., King, A. JF. & Jones, P. M., Apr 2020, In: Stem Cells. 38, 8, p. 574-584 11 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1002/stem.3134 The detection and partial localisation of heteroplasmic mutations in the mitochondrial genome of patients with diabetic retinopathy Malik, A. N., Rosa, H. S., Caseiro Soares De Menezes, E. R., Tamang, P., Hamid, Z., Naik, A., Parsade, C. K. & Sobha, S., 11 Dec 2019, (Accepted/In press) In: International Journal of Molecular Sciences. p. 1 15 p. Research output: Contribution to journal › Article › peer-review A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease Malik, A. N., Simões, I. C. M., Rosa, H. S., Khan, S., Karkucinska-Wieckowska, A. & Wieckowski, M., 8 Oct 2019, (E-pub ahead of print) In: Cells. 8, 14 p., 1221. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3390/cells8101222 Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis Gumucio, J. P., Qasawa, A. H., Ferrara, P. J., Malik, A. N., Funai, K., McDonagh, B. & Mendias, C. L., 1 Jul 2019, In: Faseb Journal. 33, 7, p. 7863-7881 19 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1096/fj.201802457RR Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L., & 132 othersRichardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W. J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K. H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H. H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y. D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3 Jan 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.ajhg.2018.12.001 View all publications
6 August 2019 Link between diabetes and Alzheimer's could lie in energy production of the brain New evidence suggests loss of energy supply to neurones is important in Alzheimer’s disease.