Biography

I lead the Houart group, which has been internationally recognised as leading research into the molecular and cellular mechanisms that drive zebrafish forebrain development and the evolutionary mechanisms underlying vertebrate brain regionalisation. My team is identifying similarities and divergences between zebrafish, mouse and human early forebrain regionalization. This basic research direction brought an understanding of profound development disorders (eg. Foxg1 syndrome). We also devote part of our research effort in understanding motor neurodegeneration and developed an original approach to understanding local RNA regulation driving neuronal maturation and neurodegenerative processes. I have established the use of genome editing in zebrafish at KCL and I drove the initiative of building KLC's state-of-the-art fish facility. We are also interested in RNA regulation in developing and mature neurites in health and disorders (ex: ALS, FTD) and understanding and therapeutic avenues for FOXG1 syndrome and related developmental neuro disorders. In 2017 I received the Suffrage Science award from the Medical Research Council.

Please see my  Research Staff Profile for more detail

Find out more about my research:

CDN - Corinne Houart

Key publications:

• Thomas-Jinu et al. 2017 Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron.
• Bielen et al. 2012 BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis. Dev Cell.
• Danesin et al. 2009 Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1. Development Cell

Key collaborators:

• Professor Christopher Shaw, King's College London
• Professor Eugene Makeyev, King's College London
• Professor Laure Bally-Cuif, King's College London
• Professor Rosalind Segal, King's College London