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David Moyes

Dr David Moyes

Senior Lecturer in Host-Microbiome Interactions

Research interests

  • Host-Microbiome Interactions

Biography

Dr Moyes is a Senior Lecturer in Host-Microbiome in the Centre for Host-Microbiome Interactions.

Throughout his career, he has been involved in investigating host-microbe interactions and the role of both microbe and host innate immune responses in these interactions. 

He gained his PhD from Harefield Hospital, Imperial College London, before working at the Kennedy Institute of Rheumatology investigating the link between microbes and rheumatoid arthritis. 

At King’s College, he was part of a team that identified the central mechanisms by which epithelial cells discriminate between commensal (harmless) and invasive (disease-causing) forms of Candida albicans.  This work lead eventually to the discovery of the novel Candidalysin toxin and its role in both disease and protection at mucosal surfaces. 

Since becoming a lecturer, his interests have evolved to investigate the role of the microbiome in causing disease. The Moyes lab studies the interactions between the human host and the microbiota that reside at the different mucosal surfaces, including bacteria, fungi and viruses. They are investigating whether changes in microbial communities associated with disease are a symptom of the disease, or whether they play a role in driving the disease process.

Current projects include investigating whether skin-associated microbes can drive or suppress conditions such as atopic dermatitis and psoriasis, whether the common oral fungus C. albicans drives cancer progression and how it does this, and the role of early recognition events that microbes trigger in epithelial cells – whether these responses go on to improve innate immune responses to pathogens. 

Moyes' group are also investigating the changes in antimicrobial resistance genes associated with the oral and gut microbiome (resistome), and their transmission within the community (mobilome). As part of this they are looking at how these resistome and moblome profiles change between different countries and health states.

    Research

    cariology project 3
    Cariology & Operative Dentistry

    Cariology & MI Operative Dentistry Research Programme

    moyes-group-banner
    Functional Microbiome Group / Moyes Group

    Investigating the functional interactions between microbes/microbial communities and mucosal surfaces.

    MIMSA - Oral Microbiome & Mucosal Immunity in COVID-19 disease

    Examining the role of 'mucosal immunity' and the 'oral microbiome' in COVID severity, and the differences seen between South Asian & white ethnic groups.

    Project status: Starting

    pg23-pg-aq-fodocs-gut-microbiome
    Centre for Host-Microbiome Interactions

    Millions of microorganisms live in and on our bodies forming microbiomes on different surfaces. Researchers in the Centre for Host Microbiome Interactions study our relationship with these bacteria and fungi in health or in oral and systemic diseases such as periodontitis, candidiasis, oral cancer and Alzheimer’s disease.

    News

    Academic Promotions

    Congratulations to the following members of the Faculty of Dentistry, Oral & Craniofacial Sciences who were awarded academic promotions.

    King's College London's Guy's Campus

    Analysing the differences in antibiotic resistance between the gut and mouth microbiome

    In a paper published today in Nature Communications, academics from King’s College London have taken the first step to examine the antimicrobial resistance...

    Researcher in lab

      Research

      cariology project 3
      Cariology & Operative Dentistry

      Cariology & MI Operative Dentistry Research Programme

      moyes-group-banner
      Functional Microbiome Group / Moyes Group

      Investigating the functional interactions between microbes/microbial communities and mucosal surfaces.

      MIMSA - Oral Microbiome & Mucosal Immunity in COVID-19 disease

      Examining the role of 'mucosal immunity' and the 'oral microbiome' in COVID severity, and the differences seen between South Asian & white ethnic groups.

      Project status: Starting

      pg23-pg-aq-fodocs-gut-microbiome
      Centre for Host-Microbiome Interactions

      Millions of microorganisms live in and on our bodies forming microbiomes on different surfaces. Researchers in the Centre for Host Microbiome Interactions study our relationship with these bacteria and fungi in health or in oral and systemic diseases such as periodontitis, candidiasis, oral cancer and Alzheimer’s disease.

      News

      Academic Promotions

      Congratulations to the following members of the Faculty of Dentistry, Oral & Craniofacial Sciences who were awarded academic promotions.

      King's College London's Guy's Campus

      Analysing the differences in antibiotic resistance between the gut and mouth microbiome

      In a paper published today in Nature Communications, academics from King’s College London have taken the first step to examine the antimicrobial resistance...

      Researcher in lab