Dr Mads Bergholt
Reader in Biophotonics
Research interests
- Dentistry
Biography
Dr Bergholt received his MSc. Degree in Engineering, Physics and Technology (optics) from the University of Southern Denmark and his Ph.D. in Biomedical Engineering from National University of Singapore.
He was awarded the Marie Curie Fellowship at Imperial College London and the United Kingdom Regenerative Medicine Platform (UKRMP) Special Merit Prize.
He is currently a Reader in Biophotonics at King's College London. His research interests include biomedical optics and light-tissue interaction, linear/non-linear optical spectroscopy/imaging, advanced endoscopy and artificial intelligence in preclinical disease models and in patients to shed new light on disease onset and progression. He holds several commercialized patents in healthcare.
Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography
Stepula, E., Walther, A. R., Jensen, M., Mehrotra, D. R., Yuan, M. H., Pedersen, S. V., Kumar, V., Gentleman, E., Albro, M. B., Hedegaard, M. A. B. & Bergholt, M. S., Dec 2024, In: Nature Communications. 15, 1, 7717.Research output: Contribution to journal › Article › peer-review
Spatially-Resolved Organoid Transfection by Porous Silicon-Mediated Optoporation
Spiteri, C., Caprettini, V., Wang, Y., Dominguez-Gil, S., Kaasalainen, M., Wang, C., Martella, D. A., McLennan, S., Vashisth, P., Gary-Bobo, M., Nguyen, C., Bergholt, M., Durand, J. O., Cunin, F. & Chiappini, C., 2024, (Accepted/In press) In: Advanced Materials. 36, 49, 2407650.Research output: Contribution to journal › Article › peer-review
Label-free 3-D molecular imaging of living tissues using Raman Spectral Projection Tomography
Bergholt, M., Gentleman, E., Walther, A., Methrota, D., Jensen, M., Yuan, M., Pedersen, S., Albro, M. & Hedegaard, M., 2024, In: Nature Communications.Research output: Contribution to journal › Article › peer-review
A comparative study of analytical tissue reflectance models using simulated and experimental data
Bahl, A., Segaud, S., Xie, Y., Shapey, J., Bergholt, M. & Vercauteren, T., 24 Mar 2024, (Accepted/In press) Biomedical Applications of Light Scattering XIV. Wax, A. & Backman, V. (eds.). SPIE, Vol. 12856. p. 1285608 4 p. 1285608. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12856).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
Opto-Lipidomics of Tissues
Jensen, M., Liu, S., Stepula, E., Martella, D., Birjandi, A. A., Farrell-Dillon, K., Chan, K. L. A., Parsons, M., Chiappini, C., Chapple, S. J., Mann, G. E., Vercauteren, T., Abbate, V. & Bergholt, M. S., 2023, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Lithiated porous silicon nanowires stimulate periodontal regeneration
Kaasalainen, M., Zhang, R., Vashisth, P., Ahmadi Birjandi, A., S'Ari, M., Martella, D., Isaacs, M., Makila, E., Wang, C., Moldenhauer, E., Clarke, P., Pinna, A., Zhang, X., Mustfa, S. A., Caprettini, V., Morrell, A., Gentleman, E., Brauer, D. S., Addison, O. & Zhang, X. & 7 others, Bergholt, M., Al-Jamal, K., Angelova Volponi, A., Salonen, J., Hondow, N., Sharpe, P. & Chiappini, C., 12 Jan 2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 487.Research output: Contribution to journal › Article › peer-review
A comparative study of analytical models of diffuse reflectance in homogeneous biological tissues: Gelatin based phantoms and Monte Carlo experiments
Bahl, A., Segaud, S., Xie, Y., Shapey, J., Bergholt, M. & Vercauteren, T., Jun 2024, In: Journal of biophotonics. 17, 6, e202300536.Research output: Contribution to journal › Article › peer-review
Deep Reinforcement Learning Based System for Intraoperative Hyperspectral Video Autofocusing
Budd, C., Qiu, J., MacCormac, O., Huber, M., Mower, C., Janatka, M., Trotouin, T., Shapey, J., Bergholt, M. S. & Vercauteren, T., 2 Oct 2023, Medical Image Computing and Computer Assisted Intervention – MICCAI 2023: 26th International Conference, Vancouver, BC, Canada, October 8–12, 2023, Proceedings, Part IX. Greenspan, H., Madabhushi, A., Mousavi, P., Salcudean, S., Duncan, J., Syeda-Mahmood, T. & Taylor, R. (eds.). Cham: Springer Nature, p. 658-667 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 14228 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy
Høgset, H., Horgan, C. C., Armstrong, J. P. K., Bergholt, M. S., Torraca, V., Chen, Q., Keane, T. J., Bugeon, L., Dallman, M. J., Mostowy, S. & Stevens, M. M., Dec 2020, In: Nature Communications. 11, 1, 6172.Research output: Contribution to journal › Article › peer-review
Lightfield Hyperspectral Imaging in Neuro-Oncology Surgery: An IDEAL 0 and 1 Study
MacCormac, O., Noonan, P., Janatka, M., Horgan, C., Bahl, A., Qiu, J., Elliot, M., Trotouin, T., Jacobs, J., Patel, S., Bergholt, M., Ashkan, K., Ourselin, S., Ebner, M., Vercauteren, T. & Shapey, J., 18 Sept 2023, In: Frontiers in Neuroscience.Research output: Contribution to journal › Article › peer-review
Synthetic white balancing for intra-operative hyperspectral imaging
Bahl, A., Horgan, C., Janatka, M., MacCormac, O., Noonan, P., Xie, Y., Qiu, J., Cavalcanti, N., Furnstahl, P., Ebner, M., Bergholt, M., Shapey, J. & Vercauteren, T., 24 Jul 2023, In: Journal of Medical Imaging. 10, 4, 046001.Research output: Contribution to journal › Article › peer-review
spectrai: a deep learning framework for spectral data
Horgan, C. C. & Bergholt, M. S., 2022, In: Journal of Spectral Imaging. 11, a7.Research output: Contribution to journal › Article › peer-review
Hybrid confocal Raman endomicroscopy for morpho-chemical tissue characterization
HORGAN, C. C., Jensen, M., Chiappini, C., Vercauteren, T., Cook, R. & BERGHOLT, M. S., 1 Apr 2022, In: Biomedical Optics Express. 13, 4, p. 2278-2285 8 p.Research output: Contribution to journal › Article › peer-review
High-Throughput Molecular Imaging via Deep-Learning-Enabled Raman Spectroscopy
Horgan, C. C., Jensen, M., Nagelkerke, A., St-Pierre, J.-P., Vercauteren, T., Stevens, M. M. & Bergholt, M. S., 7 Dec 2021, In: Analytical Chemistry. 93, 48, p. 15850-15860 11 p.Research output: Contribution to journal › Article › peer-review
Raman needle arthroscopy for in vivo molecular assessment of cartilage
Kroupa, K. R., Wu, M. I., Zhang, J., Jensen, M., Wong, W., Engiles, J. B., Grinstaff, M. W., Snyder, B. D., Bergholt, M. S. & Albro, M. B., 18 Aug 2021, (E-pub ahead of print) In: Journal of Orthopaedic Research.Research output: Contribution to journal › Article › peer-review
Image-guided Raman spectroscopy probe-tracking for tumor margin delineation
Horgan, C. C., Bergholt, M. S., Thin, M. Z., Nagelkerke, A., Kennedy, R., Kalber, T. L., Stuckey, D. J. & Stevens, M. M., 1 Mar 2021, In: Journal of biomedical optics. 26, 3Research output: Contribution to journal › Article › peer-review
In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy
Høgset, H., Horgan, C. C., Armstrong, J. P. K., Bergholt, M. S., Torraca, V., Chen, Q., Keane, T. J., Bugeon, L., Dallman, M. J., Mostowy, S. & Stevens, M. M., 2 Dec 2020, In: Nature Communications. 11, 1, p. 6172 6172.Research output: Contribution to journal › Article › peer-review
Clinician engineers – re-injecting the thinking into medicine
Sharma, N., Bergholt, M. S., Moreddu, R. & Yetisen, A. K., May 2020, In: Asia Pacific Scholar. 5, 2, p. 48-50 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Complementary techniques to analyse pericellular matrix formation by human MSC within hyaluronic acid hydrogels
Gentleman, E., Salzlechner, C., Walther, A., Schell, S., Merrild, N., Haghighi, T., Huebscher, I., Undt, G., Fan, K., Bergholt, M. & Hedegaard, M. A. B., 16 Oct 2020, In: Materials Advances. 1, p. 2888-96Research output: Contribution to journal › Article › peer-review
Multiplexed polarized hypodermic Raman needle probe for biostructural analysis of articular cartilage
Jensen, M., Horgan, C. C., Vercauteren, T., Albro, M. B. & Bergholt, M. S., 15 May 2020, In: Optics Letters. 45, 10, p. 2890-2893 4 p.Research output: Contribution to journal › Article › peer-review
Multiplexed polarised hypodermic Raman needle probe for biostructural analysis of articular cartilage
Jensen, M., Horgan, C., Vercauteren, T., Albro, M. & Bergholt, M., 15 Apr 2020, (Accepted/In press) In: Optics Letters.Research output: Contribution to journal › Letter › peer-review
Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state
Liu, H., Du, Y., St-Pierre, J. P., Bergholt, M. S., Autefage, H., Wang, J., Cai, M., Yang, G., Stevens, M. M. & Zhang, S., 1 Jan 2020, In: Science Advances. 6, 13, eaay7608.Research output: Contribution to journal › Article › peer-review
Clinician engineers: The future of medical education
Soussi, S., Bergholt, M. S., Yetisen, A. K. & Sharma, N., 2 Apr 2020, In: Medical Teacher. 42, 4, 1 p.Research output: Contribution to journal › Letter › peer-review
Raman Spectroscopy: Guiding Light for the Extracellular Matrix
Bergholt, M. S., Serio, A. & Albro, M. B., 1 Nov 2019, In: Frontiers in Bioengineering and Biotechnology. 7, 303.Research output: Contribution to journal › Review article › peer-review
Characterizing variability of in vivo Raman spectroscopic properties of different anatomical sites of normal colorectal tissue towards cancer diagnosis at colonoscopy
Bergholt, M. S., Zheng, W., Lin, K., Wang, J., Xu, H., Ho, K. Y., Teh, M., Yeoh, K. G. & Huang, Z., 20 Jan 2015, In: Analytical Chemistry. 87, 2, p. 960-6 7 p.Research output: Contribution to journal › Article › peer-review
Quantitative multi‐image analysis for biomedical Raman spectroscopic imaging
Hedegaard, M. A. B., Bergholt, M. S. & Stevens, M. M., May 2016, In: Journal of biophotonics. 9, 5, p. 542-50 9 p.Research output: Contribution to journal › Article › peer-review
Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage
Bergholt, M. S., St-Pierre, J.-P., Offeddu, G. S., Parmar, P. A., Albro, M. B., Puetzer, J. L., Oyen, M. L. & Stevens, M. M., 28 Dec 2016, In: ACS Central Science. 2, 12, p. 885-895 11 p.Research output: Contribution to journal › Article › peer-review
Quantitative volumetric Raman imaging of three dimensional cell cultures
Kallepitis, C., Bergholt, M. S., Mazo, M. M., Leonardo, V., Skaalure, S. C., Maynard, S. A. & Stevens, M. M., 22 Mar 2017, In: Nature Communications. 8, 1, 9 p., 14843.Research output: Contribution to journal › Article › peer-review
Fiberoptic confocal raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett's esophagus
Bergholt, M. S., Zheng, W., Ho, K. Y., Teh, M., Yeoh, K. G., Yan So, J. B., Shabbir, A. & Huang, Z., 1 Jan 2014, In: Gastroenterology. 146, 1, p. 27-32Research output: Contribution to journal › Article › peer-review
Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy enhances real-time in vivo diagnosis of adenomatous polyps during colonoscopy
Bergholt, M. S., Lin, K., Wang, J., Zheng, W., Xu, H., Huang, Q., Ren, J.-L., Ho, K. Y., Teh, M., Srivastava, S., Wong, B., Yeoh, K. G. & Huang, Z., Apr 2016, In: Journal of biophotonics. 9, 4, p. 333-42 10 p.Research output: Contribution to journal › Article › peer-review
Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage
Albro, M. B., Bergholt, M. S., St-Pierre, J. P., Guitart, A. V., Zlotnick, H. M., Evita, E. G. & Stevens, M., 28 Feb 2018, In: NPJ Regenerative Medicine. 3, 3.Research output: Contribution to journal › Article › peer-review
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy
Bergholt, M. S., Albro, M. B. & Stevens, M. M., Sept 2017, In: Biomaterials. 140, p. 128-137Research output: Contribution to journal › Article › peer-review
Raman spectroscopy and regenerative medicine: a review
Ember, K. J. I., Hoeve, M. A., McAughtrie, S. L., Bergholt, M. S., Dwyer, B. J., Stevens, M. M., Faulds, K., Forbes, S. J. & Campbell, C. J., 15 May 2017, In: NPJ Regenerative Medicine. 2Research output: Contribution to journal › Review article › peer-review
Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta
You, A. Y. F., Bergholt, M. S., St-Pierre, J.-P., Kit-Anan, W., Pence, I. J., Chester, A. H., Yacoub, M. H., Bertazzo, S. & Stevens, M. M., Dec 2017, In: Science Advances. 3, 12, e1701156.Research output: Contribution to journal › Article › peer-review
Single Particle Automated Raman Trapping Analysis
Penders, J., Pence, I. J., Horgan, C. C., Bergholt, M. S., Wood, C. S., Najer, A., Kauscher, U., Nagelkerke, A. & Stevens, M. M., 15 Oct 2018, In: Nature Communications. 9, 4256.Research output: Contribution to journal › Article › peer-review
Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis
Bergholt, M. S., Serio, A., McKenzie, J. S., Boyd, A., Soares, R. F., Tillner, J., Chiappini, C., Wu, V., Dannhorn, A., Takats, Z., Williams, A. & Stevens, M. M., 24 Jan 2018, In: ACS Central Science. 4, 1, p. 39-51Research output: Contribution to journal › Article › peer-review
Research
Centre for Craniofacial & Regenerative Biology
Our research goes beyond the mouth. If we understand how the entire face and head forms, we can repair damage and regenerate cells. If we unravel the causes of diseases, we can treat patients successfully. If we solve these problems, our discoveries will improve health worldwide.
Bergholt Lab
A multidisciplinary research team working on label-free bioimaging.
Regenerative Biomaterials
Regenerative biomaterials are an essential component in developing advanced cell and gene therapies for tissue regeneration. The Centre for Craniofacial & Regenerative Biology is at the forefront of regenerative biomaterials discovery and translation, thanks to unique synergies arising from leading expertise in developmental biology, bioengineering and cell technologies.
Physiological Oxygen Laboratory
Cardiovascular - Physiological Oxygen Laboratory
Lipids and Membranes Research Interest Group
A Lipids and Membranes Research Interest Group
Spatial Biology Network
The Spatial Biology Network is a cross-faculty research interest group that brings together researchers from various disciplines, ranging from technology development and molecular biology, to bioinformatics and clinical translational research, to explore the complexity of spatial biology.
The Multiscale Biofilm Research Hub (MBRH)
The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.
Synthetic biology and technological advancements
Biofilms are being studied to inspire the development of new materials and other technologies, and new approaches to probe biofilm formation.
Project status: Ongoing
News
New technology holistically images deep living tissue for the first time
The new device could lay the groundwork for an entirely new kind of osteoarthritis treatment.
Academic Promotions 2024
Many congratulations to the following members of the Faculty of Dentistry, Oral & Craniofacial Sciences who have been awarded Academic Promotions during the...
Faculty of Dentistry, Oral & Craniofacial Sciences Staff Awards
The Faculty of Dentistry, Oral & Craniofacial Sciences held their first ever Staff Awards on Thursday 18 April.
King's researchers gather for workshop on applying AI to microscopy and imaging
The King's Institute for Artificial Intelligence hosted a workshop for researchers to explore how artificial intelligence can be applied in microscopy and...
New laser technique to be developed to identify and track disease
Researchers have received a research contract of £750,000 to investigate the use of laser light in animal research.
Learning hub launched to bridge gap between medicine and engineering
Earlier this year, the Clinician Engineer Hub was launched as an international engineering training programme for medical students and early career doctors.
Welcome to our new starters
Welcome the new academics that have joined us over the recent months
Events
Applying AI Methods to Microscopy and Imaging
This event brings together bioscientists who want to use AI based methods for image analysis with computational scientists and mathematicians.
Please note: this event has passed.
Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography
Stepula, E., Walther, A. R., Jensen, M., Mehrotra, D. R., Yuan, M. H., Pedersen, S. V., Kumar, V., Gentleman, E., Albro, M. B., Hedegaard, M. A. B. & Bergholt, M. S., Dec 2024, In: Nature Communications. 15, 1, 7717.Research output: Contribution to journal › Article › peer-review
Spatially-Resolved Organoid Transfection by Porous Silicon-Mediated Optoporation
Spiteri, C., Caprettini, V., Wang, Y., Dominguez-Gil, S., Kaasalainen, M., Wang, C., Martella, D. A., McLennan, S., Vashisth, P., Gary-Bobo, M., Nguyen, C., Bergholt, M., Durand, J. O., Cunin, F. & Chiappini, C., 2024, (Accepted/In press) In: Advanced Materials. 36, 49, 2407650.Research output: Contribution to journal › Article › peer-review
Label-free 3-D molecular imaging of living tissues using Raman Spectral Projection Tomography
Bergholt, M., Gentleman, E., Walther, A., Methrota, D., Jensen, M., Yuan, M., Pedersen, S., Albro, M. & Hedegaard, M., 2024, In: Nature Communications.Research output: Contribution to journal › Article › peer-review
A comparative study of analytical tissue reflectance models using simulated and experimental data
Bahl, A., Segaud, S., Xie, Y., Shapey, J., Bergholt, M. & Vercauteren, T., 24 Mar 2024, (Accepted/In press) Biomedical Applications of Light Scattering XIV. Wax, A. & Backman, V. (eds.). SPIE, Vol. 12856. p. 1285608 4 p. 1285608. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12856).Research output: Chapter in Book/Report/Conference proceeding › Conference paper
Opto-Lipidomics of Tissues
Jensen, M., Liu, S., Stepula, E., Martella, D., Birjandi, A. A., Farrell-Dillon, K., Chan, K. L. A., Parsons, M., Chiappini, C., Chapple, S. J., Mann, G. E., Vercauteren, T., Abbate, V. & Bergholt, M. S., 2023, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Lithiated porous silicon nanowires stimulate periodontal regeneration
Kaasalainen, M., Zhang, R., Vashisth, P., Ahmadi Birjandi, A., S'Ari, M., Martella, D., Isaacs, M., Makila, E., Wang, C., Moldenhauer, E., Clarke, P., Pinna, A., Zhang, X., Mustfa, S. A., Caprettini, V., Morrell, A., Gentleman, E., Brauer, D. S., Addison, O. & Zhang, X. & 7 others, Bergholt, M., Al-Jamal, K., Angelova Volponi, A., Salonen, J., Hondow, N., Sharpe, P. & Chiappini, C., 12 Jan 2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 487.Research output: Contribution to journal › Article › peer-review
A comparative study of analytical models of diffuse reflectance in homogeneous biological tissues: Gelatin based phantoms and Monte Carlo experiments
Bahl, A., Segaud, S., Xie, Y., Shapey, J., Bergholt, M. & Vercauteren, T., Jun 2024, In: Journal of biophotonics. 17, 6, e202300536.Research output: Contribution to journal › Article › peer-review
Deep Reinforcement Learning Based System for Intraoperative Hyperspectral Video Autofocusing
Budd, C., Qiu, J., MacCormac, O., Huber, M., Mower, C., Janatka, M., Trotouin, T., Shapey, J., Bergholt, M. S. & Vercauteren, T., 2 Oct 2023, Medical Image Computing and Computer Assisted Intervention – MICCAI 2023: 26th International Conference, Vancouver, BC, Canada, October 8–12, 2023, Proceedings, Part IX. Greenspan, H., Madabhushi, A., Mousavi, P., Salcudean, S., Duncan, J., Syeda-Mahmood, T. & Taylor, R. (eds.). Cham: Springer Nature, p. 658-667 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 14228 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy
Høgset, H., Horgan, C. C., Armstrong, J. P. K., Bergholt, M. S., Torraca, V., Chen, Q., Keane, T. J., Bugeon, L., Dallman, M. J., Mostowy, S. & Stevens, M. M., Dec 2020, In: Nature Communications. 11, 1, 6172.Research output: Contribution to journal › Article › peer-review
Lightfield Hyperspectral Imaging in Neuro-Oncology Surgery: An IDEAL 0 and 1 Study
MacCormac, O., Noonan, P., Janatka, M., Horgan, C., Bahl, A., Qiu, J., Elliot, M., Trotouin, T., Jacobs, J., Patel, S., Bergholt, M., Ashkan, K., Ourselin, S., Ebner, M., Vercauteren, T. & Shapey, J., 18 Sept 2023, In: Frontiers in Neuroscience.Research output: Contribution to journal › Article › peer-review
Synthetic white balancing for intra-operative hyperspectral imaging
Bahl, A., Horgan, C., Janatka, M., MacCormac, O., Noonan, P., Xie, Y., Qiu, J., Cavalcanti, N., Furnstahl, P., Ebner, M., Bergholt, M., Shapey, J. & Vercauteren, T., 24 Jul 2023, In: Journal of Medical Imaging. 10, 4, 046001.Research output: Contribution to journal › Article › peer-review
spectrai: a deep learning framework for spectral data
Horgan, C. C. & Bergholt, M. S., 2022, In: Journal of Spectral Imaging. 11, a7.Research output: Contribution to journal › Article › peer-review
Hybrid confocal Raman endomicroscopy for morpho-chemical tissue characterization
HORGAN, C. C., Jensen, M., Chiappini, C., Vercauteren, T., Cook, R. & BERGHOLT, M. S., 1 Apr 2022, In: Biomedical Optics Express. 13, 4, p. 2278-2285 8 p.Research output: Contribution to journal › Article › peer-review
High-Throughput Molecular Imaging via Deep-Learning-Enabled Raman Spectroscopy
Horgan, C. C., Jensen, M., Nagelkerke, A., St-Pierre, J.-P., Vercauteren, T., Stevens, M. M. & Bergholt, M. S., 7 Dec 2021, In: Analytical Chemistry. 93, 48, p. 15850-15860 11 p.Research output: Contribution to journal › Article › peer-review
Raman needle arthroscopy for in vivo molecular assessment of cartilage
Kroupa, K. R., Wu, M. I., Zhang, J., Jensen, M., Wong, W., Engiles, J. B., Grinstaff, M. W., Snyder, B. D., Bergholt, M. S. & Albro, M. B., 18 Aug 2021, (E-pub ahead of print) In: Journal of Orthopaedic Research.Research output: Contribution to journal › Article › peer-review
Image-guided Raman spectroscopy probe-tracking for tumor margin delineation
Horgan, C. C., Bergholt, M. S., Thin, M. Z., Nagelkerke, A., Kennedy, R., Kalber, T. L., Stuckey, D. J. & Stevens, M. M., 1 Mar 2021, In: Journal of biomedical optics. 26, 3Research output: Contribution to journal › Article › peer-review
In vivo biomolecular imaging of zebrafish embryos using confocal Raman spectroscopy
Høgset, H., Horgan, C. C., Armstrong, J. P. K., Bergholt, M. S., Torraca, V., Chen, Q., Keane, T. J., Bugeon, L., Dallman, M. J., Mostowy, S. & Stevens, M. M., 2 Dec 2020, In: Nature Communications. 11, 1, p. 6172 6172.Research output: Contribution to journal › Article › peer-review
Clinician engineers – re-injecting the thinking into medicine
Sharma, N., Bergholt, M. S., Moreddu, R. & Yetisen, A. K., May 2020, In: Asia Pacific Scholar. 5, 2, p. 48-50 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Complementary techniques to analyse pericellular matrix formation by human MSC within hyaluronic acid hydrogels
Gentleman, E., Salzlechner, C., Walther, A., Schell, S., Merrild, N., Haghighi, T., Huebscher, I., Undt, G., Fan, K., Bergholt, M. & Hedegaard, M. A. B., 16 Oct 2020, In: Materials Advances. 1, p. 2888-96Research output: Contribution to journal › Article › peer-review
Multiplexed polarized hypodermic Raman needle probe for biostructural analysis of articular cartilage
Jensen, M., Horgan, C. C., Vercauteren, T., Albro, M. B. & Bergholt, M. S., 15 May 2020, In: Optics Letters. 45, 10, p. 2890-2893 4 p.Research output: Contribution to journal › Article › peer-review
Multiplexed polarised hypodermic Raman needle probe for biostructural analysis of articular cartilage
Jensen, M., Horgan, C., Vercauteren, T., Albro, M. & Bergholt, M., 15 Apr 2020, (Accepted/In press) In: Optics Letters.Research output: Contribution to journal › Letter › peer-review
Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state
Liu, H., Du, Y., St-Pierre, J. P., Bergholt, M. S., Autefage, H., Wang, J., Cai, M., Yang, G., Stevens, M. M. & Zhang, S., 1 Jan 2020, In: Science Advances. 6, 13, eaay7608.Research output: Contribution to journal › Article › peer-review
Clinician engineers: The future of medical education
Soussi, S., Bergholt, M. S., Yetisen, A. K. & Sharma, N., 2 Apr 2020, In: Medical Teacher. 42, 4, 1 p.Research output: Contribution to journal › Letter › peer-review
Raman Spectroscopy: Guiding Light for the Extracellular Matrix
Bergholt, M. S., Serio, A. & Albro, M. B., 1 Nov 2019, In: Frontiers in Bioengineering and Biotechnology. 7, 303.Research output: Contribution to journal › Review article › peer-review
Characterizing variability of in vivo Raman spectroscopic properties of different anatomical sites of normal colorectal tissue towards cancer diagnosis at colonoscopy
Bergholt, M. S., Zheng, W., Lin, K., Wang, J., Xu, H., Ho, K. Y., Teh, M., Yeoh, K. G. & Huang, Z., 20 Jan 2015, In: Analytical Chemistry. 87, 2, p. 960-6 7 p.Research output: Contribution to journal › Article › peer-review
Quantitative multi‐image analysis for biomedical Raman spectroscopic imaging
Hedegaard, M. A. B., Bergholt, M. S. & Stevens, M. M., May 2016, In: Journal of biophotonics. 9, 5, p. 542-50 9 p.Research output: Contribution to journal › Article › peer-review
Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage
Bergholt, M. S., St-Pierre, J.-P., Offeddu, G. S., Parmar, P. A., Albro, M. B., Puetzer, J. L., Oyen, M. L. & Stevens, M. M., 28 Dec 2016, In: ACS Central Science. 2, 12, p. 885-895 11 p.Research output: Contribution to journal › Article › peer-review
Quantitative volumetric Raman imaging of three dimensional cell cultures
Kallepitis, C., Bergholt, M. S., Mazo, M. M., Leonardo, V., Skaalure, S. C., Maynard, S. A. & Stevens, M. M., 22 Mar 2017, In: Nature Communications. 8, 1, 9 p., 14843.Research output: Contribution to journal › Article › peer-review
Fiberoptic confocal raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett's esophagus
Bergholt, M. S., Zheng, W., Ho, K. Y., Teh, M., Yeoh, K. G., Yan So, J. B., Shabbir, A. & Huang, Z., 1 Jan 2014, In: Gastroenterology. 146, 1, p. 27-32Research output: Contribution to journal › Article › peer-review
Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy enhances real-time in vivo diagnosis of adenomatous polyps during colonoscopy
Bergholt, M. S., Lin, K., Wang, J., Zheng, W., Xu, H., Huang, Q., Ren, J.-L., Ho, K. Y., Teh, M., Srivastava, S., Wong, B., Yeoh, K. G. & Huang, Z., Apr 2016, In: Journal of biophotonics. 9, 4, p. 333-42 10 p.Research output: Contribution to journal › Article › peer-review
Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage
Albro, M. B., Bergholt, M. S., St-Pierre, J. P., Guitart, A. V., Zlotnick, H. M., Evita, E. G. & Stevens, M., 28 Feb 2018, In: NPJ Regenerative Medicine. 3, 3.Research output: Contribution to journal › Article › peer-review
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy
Bergholt, M. S., Albro, M. B. & Stevens, M. M., Sept 2017, In: Biomaterials. 140, p. 128-137Research output: Contribution to journal › Article › peer-review
Raman spectroscopy and regenerative medicine: a review
Ember, K. J. I., Hoeve, M. A., McAughtrie, S. L., Bergholt, M. S., Dwyer, B. J., Stevens, M. M., Faulds, K., Forbes, S. J. & Campbell, C. J., 15 May 2017, In: NPJ Regenerative Medicine. 2Research output: Contribution to journal › Review article › peer-review
Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta
You, A. Y. F., Bergholt, M. S., St-Pierre, J.-P., Kit-Anan, W., Pence, I. J., Chester, A. H., Yacoub, M. H., Bertazzo, S. & Stevens, M. M., Dec 2017, In: Science Advances. 3, 12, e1701156.Research output: Contribution to journal › Article › peer-review
Single Particle Automated Raman Trapping Analysis
Penders, J., Pence, I. J., Horgan, C. C., Bergholt, M. S., Wood, C. S., Najer, A., Kauscher, U., Nagelkerke, A. & Stevens, M. M., 15 Oct 2018, In: Nature Communications. 9, 4256.Research output: Contribution to journal › Article › peer-review
Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis
Bergholt, M. S., Serio, A., McKenzie, J. S., Boyd, A., Soares, R. F., Tillner, J., Chiappini, C., Wu, V., Dannhorn, A., Takats, Z., Williams, A. & Stevens, M. M., 24 Jan 2018, In: ACS Central Science. 4, 1, p. 39-51Research output: Contribution to journal › Article › peer-review
Research
Centre for Craniofacial & Regenerative Biology
Our research goes beyond the mouth. If we understand how the entire face and head forms, we can repair damage and regenerate cells. If we unravel the causes of diseases, we can treat patients successfully. If we solve these problems, our discoveries will improve health worldwide.
Bergholt Lab
A multidisciplinary research team working on label-free bioimaging.
Regenerative Biomaterials
Regenerative biomaterials are an essential component in developing advanced cell and gene therapies for tissue regeneration. The Centre for Craniofacial & Regenerative Biology is at the forefront of regenerative biomaterials discovery and translation, thanks to unique synergies arising from leading expertise in developmental biology, bioengineering and cell technologies.
Physiological Oxygen Laboratory
Cardiovascular - Physiological Oxygen Laboratory
Lipids and Membranes Research Interest Group
A Lipids and Membranes Research Interest Group
Spatial Biology Network
The Spatial Biology Network is a cross-faculty research interest group that brings together researchers from various disciplines, ranging from technology development and molecular biology, to bioinformatics and clinical translational research, to explore the complexity of spatial biology.
The Multiscale Biofilm Research Hub (MBRH)
The Multiscale Biofilm Research Hub (MBRH) has been established to promote interdisciplinary interactions and focus microbial biofilm related research at King’s.
Synthetic biology and technological advancements
Biofilms are being studied to inspire the development of new materials and other technologies, and new approaches to probe biofilm formation.
Project status: Ongoing
News
New technology holistically images deep living tissue for the first time
The new device could lay the groundwork for an entirely new kind of osteoarthritis treatment.
Academic Promotions 2024
Many congratulations to the following members of the Faculty of Dentistry, Oral & Craniofacial Sciences who have been awarded Academic Promotions during the...
Faculty of Dentistry, Oral & Craniofacial Sciences Staff Awards
The Faculty of Dentistry, Oral & Craniofacial Sciences held their first ever Staff Awards on Thursday 18 April.
King's researchers gather for workshop on applying AI to microscopy and imaging
The King's Institute for Artificial Intelligence hosted a workshop for researchers to explore how artificial intelligence can be applied in microscopy and...
New laser technique to be developed to identify and track disease
Researchers have received a research contract of £750,000 to investigate the use of laser light in animal research.
Learning hub launched to bridge gap between medicine and engineering
Earlier this year, the Clinician Engineer Hub was launched as an international engineering training programme for medical students and early career doctors.
Welcome to our new starters
Welcome the new academics that have joined us over the recent months
Events
Applying AI Methods to Microscopy and Imaging
This event brings together bioscientists who want to use AI based methods for image analysis with computational scientists and mathematicians.
Please note: this event has passed.