Dr Paul Lavender Academics Supervisors Reader in Respiratory Epigenetics School Academic Lead, People & Culture. Research subject areas Biomedical and life sciences Contact details paul.lavender@kcl.ac.uk
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons Molecular, Epigenetic and Gene Expression Profiling of Triple Negative Essential Thrombocythaemia Identification of a transcription factor network regulating anti-TNF mediated IL10 expression in human CD4+ T cells Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in Acute Promyelocytic Leukemia NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression SOX2 drives bronchial dysplasia in a novel organotypic model of early human squamous lung cancer Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis Autocrine vitamin D signaling switches off pro-inflammatory programs of T GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage Patients with triple-negative, JAK2V617F- and CALR-mutated essential thrombocythemia share a unique gene expression signature Quantitative assessment of NFκB transcription factor activity Profiling of H3K27Ac reveals the influence of asthma on the epigenome of the airway epithelium. Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment Multi-omic analysis of the effects of low frequency ventilation during cardiopulmonary bypass surgery IKZF3/AIOLOs is associated with but not +sufficient T cells for the expression of IL-10 by CD4: IKZF3 is associated with IL-10+ CD4+ T cells Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells DNA methylation modules in airway smooth muscle are associated with asthma severity Regulation of Wnt signaling by Sox proteins: XSox17α/β and XSox3 physically interact with β-catenin CRISPR-based reagents to study the influence of the epigenome on gene expression The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10 Correction of Defective T-regulatory Cells From Patients With Crohn’s Disease by Ex Vivo Ligation of Retinoic Acid Receptor Alpha miR-29b directly targets activation-induced cytidine deaminase in human B cells and can limit its inappropriate expression in naïve B cells Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development The nasal mucosal late allergic reaction to grass pollen involves type 2 inflammation (IL-5 and IL-13), the inflammasome (IL-1β), and complement Tissue extravasation induces ‘complement-licensing’ required for immune cell effector function: SI: XXVI ICW Kanazawa 2016 T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1β-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes C5L2-mediated signals control contraction of human Th1 responses Recovering the CD4+ T cells responsiveness to glucocorticoids: an approach to improving therapy for glucocorticoid resistant asthma IL-2 Regulates Expression of C-MAF in Human CD4 T Cells Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping BASIC SCIENCE FOR THE CHEST PHYSICIAN MicroRNAs in lung diseases Control of cytokine gene transcription in Th1 and Th2 cells Interleukin-17: a new role in steroid hypo-responsiveness? Repression of TNF-alpha-induced IL-8 expression by the glucocorticoid receptor-beta involves inhibition of histone H4 acetylation Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma Control of IL-4 expression in T helper 1 and 2 cells The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases Regulation of GM-CSF expression by the transcription factor c-Maf Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signalling and involves histone deacetylase recruitment Interleukin 10 secreting ‘regulatory’ T cells induced by glucocorticoids and beta2 –agonists Presentation at the National Asthma Campaign International Congress, June 1999 - Controlling the inflammatory response through transcriptional mechanisms Characterization of a palindromic enhancer element in the promoters of IL4, IL5, and IL13 cytokine genes Suppression of granulocyte-macrophage colony-stimulating factor expression by glucocorticoids involves inhibition of enhancer function by the glucocorticoid receptor binding to composite NF-AT/activator protein-1 elements View all publications