
Professor Rivka Isaacson
Professor of Molecular Biophysics
- Graduate School Director, Natural, Mathematical and Engineering Sciences
- Chemistry in Cells Module Lead
Research interests
- Chemistry
Biography
Professor Rivka Isaacson is Professor of Molecular Biophysics in the Department of Chemistry, King’s College London.
Rivka obtained a BSc. in Biochemistry from the University of Manchester in 1997, followed by a Ph.D. in Chemistry from the University of Cambridge in 2001, under the supervision of Professor Sir Alan Fersht, FRS. She carried out post-doctoral research at Harvard Medical School with Professor Pamela Silver, and then at Imperial College London with Professor Steve Matthews. Subsequently, she worked at the Imperial College Drug Discovery Centre before starting her own research group in 2009 funded by an MRC New Investigator Research Grant.
Rivka is passionate about radical interdisciplinarity, conducting many projects across the arts-sciences interface, including an ongoing multimedia collaboration with London Fine Art Studios called Viewing the Invisible and a longstanding relationship with the Iris Murdoch Research Centre at Chichester University around science and literature.
Rivka currently serves on the UKRI Physics of Life steering group and the executive committee for the national Collaborative Computing Project for NMR. She was the 2021 winner of the Judith Howard prize from the Biophysical Sciences Institute at Durham University.
Research Interests
- Control of protein degradation
- Gene expression regulation in bacterial sporulation
- Membrane protein targeting
- Chaperone/Protease systems
- Quality control within the crowded cell
Teaching
- Protein Structure and Function
- Chemistry in Cells
- Molecular Biology in Chemistry
- UG Research Methods Literature Review
- MSci Research Project & Dissertation
- MRes Research Project in Interdisciplinary Chemistry
Research profile
For more information on Professor Isaacson's research please see her Research Portal page
The Isaacson Group
Research Associates:
- Sasha Evans
Postgraduate Researchers:
- Bethany Haynes
- Delia Capatina
- Holly Barter
The Isaacson group uses biophysics techniques, including NMR spectroscopy, X-ray crystallography and cryo-electron microscopy, to probe macromolecular structure and interactions of molecules relevant to health and disease. Their research questions, largely BBSRC funded, focus on mechanisms for maintaining proteostasis within the crowded cell in both mammalian and bacterial systems.
Developmentally regulated proteolysis by MdfA and ClpCP mediates metabolic differentiation during Bacillus subtilis sporulation
Riley, E. P., Lyda, J. A., Reyes-Matte, O., Sugie, J., Kasu, I. R., Enustun, E., Armbruster, E. G., Ravishankar, S., Isaacson, R. L., Camp, A. H., Lopez-Garrido, J. & Pogliano, K., 1 Apr 2025, In: Genes & development. 39, 7-8, p. 524-537 14 p.Research output: Contribution to journal › Article › peer-review
MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore
Massoni, S. C., Evans, N. J., Hantke, I., Fenton, C., Torpey, J. H., Collins, K. M., Krysztofinska, E. M., Muench, J. H., Thapaliya, A., Martínez-Lumbreras, S., Hart Ferrell, S., Slater, C., Wang, X., Fekade, R., Obwar, S., Yin, S., Vazquez, A., Prior, C. B., Turgay, K. & Isaacson, R. L. & 1 others, Camp, A. H., 1 Apr 2025, In: Genes & development. 39, 7, p. 510-523 14 p.Research output: Contribution to journal › Article › peer-review
Drug Discovery: How to exploit the recycling system of a cell
Evans, S., Haynes, B., Capatina, D. & Isaacson, R., 21 Feb 2025, In: eLife.Research output: Contribution to journal › Editorial
Biochemical methods for producing and characterising recombinant spider silks
Isaacson, R., Maraldo, A., Evans, S., Torpey, J., Rawal, A., Yarger, J., Marquis, C. & Blamires, S., 21 Jan 2025, In: Frontiers in Arachnid Science.Research output: Contribution to journal › Review article › peer-review
‘It depends on the liver’: Alcoholism, Detoxification, Regeneration and Wound-healing in A Fairly Honourable Defeat
Isaacson, R., 1 Sept 2024, In: The Iris Murdoch Review. 15, p. 61-70 10 p.Research output: Contribution to journal › Article › peer-review
Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis
Ablat, G., Lawton, N., Alam, R., Haynes, B. A., Hossain, S., Hicks, T., Evans, S. L., Jarvis, J. A., Nott, T. J., Isaacson, R. L. & Müller, M. M., 14 Aug 2024, In: Journal of the American Chemical Society. 146, 32, p. 22622-22628 7 p.Research output: Contribution to journal › Article › peer-review
A novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore
Massoni, S. C., Evans, N., Hantke, I., Fenton, C., Torpey, J., Collins, K., Krysztofinska, E., Muench, J., Thapaliya, A., Martinez Lumbreras, S., Hart Martin, S., Prior, C. B., Turgay, K., Isaacson, R. & Camp, A. H., 3 Mar 2024, In: bioRxiv.Research output: Contribution to journal › Article
Celestial sabbatical
Isaacson, R., 5 Jun 2024, In: Nature Physics. 20, p. 883 1 p.Research output: Contribution to journal › Book/Film/Article review › peer-review
Olga Kennard as an Icon of Interdisciplinarity
Isaacson, R., 17 Apr 2024, In: CRYSTAL GROWTH AND DESIGN. 24, 8, p. 3095-3099 5 p.Research output: Contribution to journal › Editorial › peer-review
Meeting Reports: Third Engineering Recombinant Proteins for Structural and Functional Studies Training Course, 10–11 November 2022, University of Liverpool
Stollar, E., Burgess-Brown, N. & Isaacson, R., 5 Jan 2024, In: Biochemist. 45, 5, 40.Research output: Contribution to journal › Article › peer-review
p97 and close encounters of every kind: A brief review
Dreveny, I., Pye, V. E., Beuron, F., Briggs, L. C., Isaacson, R. L., Matthews, S. J., McKeown, C., Yuan, X., Zhang, X. & Freemont, P. S., Nov 2004, In: Biochemical Society Transactions. 32, 5, p. 715-720 6 p.Research output: Contribution to journal › Article › peer-review
Elucidating the mechanism of familial amyloidosis-Finnish type: NMR studies of human gelsolin domain 2
Kazmirski, S. L., Howard, M. J., Isaacson, R. L. & Fersht, A. R., 26 Sept 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 20, p. 10706-10711 6 p.Research output: Contribution to journal › Article › peer-review
Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type
Isaacson, R. L., Weeds, A. G. & Fersht, A. R., 28 Sept 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11247-11252 6 p.Research output: Contribution to journal › Article › peer-review
Detailed structural insights into the p97-Npl4-Ufd1 interface
Isaacson, R. L., Pye, V. E., Simpson, P., Meyer, H. H., Zhang, X., Freemont, P. S. & Matthews, S., 20 Jul 2007, In: Journal of Biological Chemistry. 282, 29, p. 21361-21369 9 p.Research output: Contribution to journal › Article › peer-review
A new labeling method for methyl transverse relaxation-optimized spectroscopy NMR spectra of alanine residues
Isaacson, R. L., Simpson, P. J., Liu, M., Cota, E., Zhang, X., Freemont, P. & Matthews, S., 19 Dec 2007, In: Journal of the American Chemical Society. 129, 50, p. 15428-15429 2 p.Research output: Contribution to journal › Article › peer-review
Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: Variations in yield, growth, and differentiation
Phinney, D. G., Kopen, G., Isaacson, R. L. & Prockop, D. J., 15 Mar 1999, In: Journal of Cellular Biochemistry. 72, 4, p. 570-585 16 p.Research output: Contribution to journal › Article › peer-review
Loss of a metal-binding site in gelsolin leads to familial amyloidosis-finnish type
Kazmirski, S. L., Isaacson, R. L., An, C., Buckle, A., Johnson, C. M., Daggett, V. & Fersht, A. R., 2002, In: Nature Structural Biology. 9, 2, p. 112-116 5 p.Research output: Contribution to journal › Article › peer-review
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites
Park, S., Isaacson, R., Kim, H. T., Silver, P. A. & Wagner, G., Jul 2005, In: Structure. 13, 7, p. 995-1005 11 p.Research output: Contribution to journal › Article › peer-review
Conformational changes in the AAA ATPase p97-p47 adaptor complex
Beuron, F., Dreveny, I., Yuan, X., Pye, V. E., Mckeown, C., Briggs, L. C., Cliff, M. J., Kaneko, Y., Wallis, R., Isaacson, R. L., Ladbury, J. E., Matthews, S. J., Kondo, H., Zhang, X. & Freemont, P. S., 3 May 2006, In: EMBO Journal. 25, 9, p. 1967-1976 10 p.Research output: Contribution to journal › Article › peer-review
Targeting bacterial degradation machinery as an antibacterial strategy
Petkov, R., Camp, A. H., Isaacson, R. L. & Torpey, J. H., 15 Nov 2023, In: Biochemical Journal. 480, 21, p. 1719-1731 13 p.Research output: Contribution to journal › Review article › peer-review
Structural Analysis of Bacillus subtilis Sigma Factors
Collins, K. M., Evans, N. J., Torpey, J. H., Harris, J. M., Haynes, B. A., Camp, A. H. & Isaacson, R. L., 20 Apr 2023, In: Microorganisms. 11, 4, 1077.Research output: Contribution to journal › Article › peer-review
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains
Morris, O. M., Torpey, J. H. & Isaacson, R. L., 1 Oct 2021, In: Open Biology. 11, 10, p. 210222 1 p., 210222.Research output: Contribution to journal › Article › peer-review
Viewing the Invisible: Exploring common methodology across disciplines
Witheridge, A. & Isaacson, R., Dec 2019, In: PLoS Biology. 17, 12, p. e3000577 e3000577.Research output: Contribution to journal › Article › peer-review
Editorial: Weak interactions in molecular machinery
Isaacson, R. L. & Díaz-Moreno, I., 1 Jan 2019, In: Frontiers in Molecular Biosciences. 5, JAN, 117.Research output: Contribution to journal › Editorial › peer-review
The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease
Benarroch, R., Austin, J. M., Ahmed, F. & Isaacson, R. L., 18 Dec 2018, (E-pub ahead of print) In: Advances in Protein Chemistry and Structural Biology.Research output: Contribution to journal › Article › peer-review
Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
Martínez-Lumbreras, S., Krysztofinska, E. M., Thapaliya, A., Spilotros, A., Matak-Vinkovic, D., Salvadori, E., Roboti, P., Nyathi, Y., Muench, J. H., Roessler, M. M., Svergun, D. I., High, S. & Isaacson, R. L., 11 Jul 2018, In: BMC Biology. 16, 1, 18 p., 76.Research output: Contribution to journal › Article › peer-review
Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB
Martínez-Lumbreras, S., Alfano, C., Evans, N. J., Collins, K. M., Flanagan, K. A., Atkinson, R. A., Krysztofinska, E. M., Vydyanath, A., Jackter, J., Fixon-Owoo, S., Camp, A. H. & Isaacson, R. L., 8 Mar 2018, (E-pub ahead of print) In: Structure.Research output: Contribution to journal › Article › peer-review
Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp
Krysztofinska, E. M., Evans, N. J., Thapaliya, A., Murray, J. W., Morgan, R. M. L., Martinez-Lumbreras, S. & Isaacson, R. L., 11 Oct 2017, In: Frontiers in Molecular Biosciences. 4, p. 68Research output: Contribution to journal › Article › peer-review
A Novel RNA Polymerase-binding Protein that interacts with a Sigma-Factor Docking Site
Wang Erickson, A. F., Deighan, P., Chen, S., Barrasso, K., Garcia, C. P., Martínez-Lumbreras, S., Alfano, C., Krysztofinska, E. M., Thapaliya, A., Camp, A. H., Isaacson, R. L., Hochschild, A. & Losick, R., 19 Jun 2017, (E-pub ahead of print) In: Molecular Microbiology.Research output: Contribution to journal › Article › peer-review
SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism
Thapaliya, A., Nyathi, Y., Martinez Lumbreras, S., Krysztofinska, E., Evans, N., Terry, I. L., High, S. & Isaacson, R. L., 9 Nov 2016, (E-pub ahead of print) In: Scientific Reports. 6, 12 p., 36622.Research output: Contribution to journal › Article › peer-review
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse
Ingham, N. J., Carlisle, F., Pearson, S., Lewis, M. A., Buniello, A., Chen, J., Isaacson, R. L., Pass, J., White, J. K., Dawson, S. J. & Steel, K. P., 2016, In: Scientific Reports. 6, p. 1-13 13 p., 28964.Research output: Contribution to journal › Article › peer-review
Structural and functional insights into the E3 ligase, RNF126
Krysztofinska, E. M., Martínez-Lumbreras, S., Thapaliya, A., Evans, N. J., High, S. & Isaacson, R. L., 19 May 2016, (E-pub ahead of print) In: Scientific Reports. 6, 26433.Research output: Contribution to journal › Article › peer-review
Autosomal-Recessive Hearing Impairment due to Rare Missense Variants within S1PR2
Santos-Cortez, R. L. P., Faridi, R., Rehman, A. U., Lee, K., Ansar, M., Wang, X., Morell, R. J., Isaacson, R., Belyantseva, I. A., Dai, H., Acharya, A., Qaiser, T. A., Muhammad, D., Ali, R. A., Shams, S., Hassan, M. J., Shahzad, S., Raza, S. I., Bashir, Z.-E.-H. & Smith, J. D. & 7 others, Nickerson, D. A., Bamshad, M. J., Riazuddin, S., Ahmad, W., Friedman, T. B., Leal, S. M. & University of Washington Center for Mendelian Genomics, 21 Jan 2016, (E-pub ahead of print) In: American Journal of Human Genetics. 98, 2, p. 331-338 7 p.Research output: Contribution to journal › Article › peer-review
Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha
Roberts, J. D., Thapaliya, A., Martínez-Lumbreras, S., Krysztofinska, E. M. & Isaacson, R. L., 18 Dec 2015, In: Frontiers in Bioscience. 2, p. 71Research output: Contribution to journal › Article › peer-review
1H, 13C and 15N assignments of Sgt2 N-terminal dimerisation domain and its binding partner, Get5 Ubiquitin-like domain
Simon, A. C., Simpson, P. J., Hawthorne, W., Hale, L. R., Goldstone, R. M. & Isaacson, R. L., Oct 2013, In: Biomolecular NMR Assignments. 7, 2, p. 271-4 4 p.Research output: Contribution to journal › Article › peer-review
ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure
Buyandelger, B., Mansfield, C., Kostin, S., Choi, O., Roberts, A. M., Ware, J. S., Mazzarotto, F., Pesce, F., Buchan, R., Isaacson, R., Vouffo, J., Gunkel, S., Knöll, G., McSweeney, S. J., Wei, H., Perrot, A., Pfeiffer, C., Toliat, M. R., Ilieva, K. & Krysztofinska, E. & 27 others, López-Olañeta, M. M., Gómez-Salinero, J. M., Schmidt, A., Ng, K.-E., Teucher, N., Chen, J., Teichmann, M., Eilers, M., Haverkamp, W., Regitz-Zagrosek, V., Hasenfuss, G., Braun, T., Pennell, D. J., Gould, I., Barton, P. J. R., Lara-Pezzi, E., Schafer, S., Hübner, N., Felkin, L. E., O'Regan, D. P., Petretto, E., Brand, T., Milting, H., Nürnberg, P., Schneider, M. D., Prasad, S. & Knöll, R., Oct 2015, In: Circulation-Cardiovascular Genetics. 8, 5, p. 643-652 9 p.Research output: Contribution to journal › Article › peer-review
Solution Structure of the SGTA Dimerisation Domain and Investigation of Its Interactions with the Ubiquitin-Like Domains of BAG6 and UBL4A
Darby, J. F., Krysztofinska, E. M., Simpson, P. J., Simon, A. C., Leznicki, P., Sriskandarajah, N., Bishop, D. S., Hale, L. R., Alfano, C., Conte, M. R., Martínez-Lumbreras, S., Thapaliya, A., High, S. & Isaacson, R. L., 21 Nov 2014, In: PLOS One. 9, 11, 19 p., e113281.Research output: Contribution to journal › Article › peer-review
Insights into adaptor binding to the AAA protein p97
Yeung, H. O., Kloppsteck, P., Niwa, H., Isaacson, R., Matthews, S., Zhang, X. & Freemont, P. S., Feb 2008, In: Biochemical Society Transactions. 36, 1, p. 62-67 6 p.Research output: Contribution to journal › Article › peer-review
Automated Assignment in Selectively Methyl-Labeled Proteins
Xu, Y., Liu, M., Simpson, P. J., Isaacson, R., Cota, E., Marchant, J., Yang, D., Zhang, X., Freemont, P. & Matthews, S., 15 Jul 2009, In: Journal of the American Chemical Society. 131, 27, p. 9480-9481 1 p.Research output: Contribution to journal › Article › peer-review
Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting
Simpson, P. J., Schwappach, B., Dohlman, H. G. & Isaacson, R., 11 Aug 2010, In: Structure. 18, 8, p. 897-902 6 p.Research output: Contribution to journal › Literature review › peer-review
Protein construct optimization: data sharing strategy
Polizzi, K. M. & Isaacson, R., May 2012, In: Protein & cell. 3, 5, p. 321-322 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins
Simon, A. C., Simpson, P. J., Goldstone, R. M., Krysztofinska, E. M., Murray, J. W., High, S. & Isaacson, R., 22 Jan 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1327-1332 6 p.Research output: Contribution to journal › Article › peer-review
The Association of BAG6 with SGTA and Tail-Anchored Proteins
Leznicki, P., Roebuck, Q. P., Wunderley, L., Clancy, A., Krysztofinska, E. M., Isaacson, R. L., Warwicker, J., Schwappach, B. & High, S., 22 Mar 2013, In: PL o S One . 8, 3, 15 p., e59590.Research output: Contribution to journal › Article › peer-review
Structural Insights into Serine-rich Fimbriae from Gram-positive Bacteria
Ramboarina, S., Garnett, J. A., Zhou, M., Li, Y., Peng, Z., Taylor, J. D., Lee, W.-C., Bodey, A., Murray, J. W., Alguel, Y., Bergeron, J., Bardiaux, B., Sawyer, E., Isaacson, R., Tagliaferri, C., Cota, E., Nilges, M., Simpson, P., Ruiz, T. & Wu, H. & 1 others, Matthews, S., 15 Oct 2010, In: Journal of Biological Chemistry. 285, 42, p. 32446 - 32457 12 p.Research output: Contribution to journal › Article › peer-review
Research

Microbes in Health & Disease
The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.
News
Scientists discover protein key to bacteria's survival in extreme environments
The discovery sheds light on how certain bacteria form spores for survival, enabling superbugs to evade hospital cleaning

King's Chemist joins science greats in prestigious Royal Institution Christmas Lecture
Professor Rivka Isaacson helped reveal the truth about Artificial Intelligence in a three-part special series on BBC 4.

International Women's Day 2021: The contribution of the women at King's to the global response to COVID-19
As part of the UN’s International Women’s Day 2021 theme “Women in leadership: Achieving an equal future in a COVID-19 world”, we recognise the important...

King's chemist Dr Rivka Isaacson shortlisted as Falling Walls finalist
Rivka’s collaboration with the London Fine Arts studio via the 2019 multimedia project Viewing the Invisible has been shortlisted in the Science in the Arts...

Viewing the Invisible offers a fresh approach to thinking about science and art
The exhibition showcased parallels between the two disciplines and enabled a greater understanding of the value of collaborative working.

Viewing the Invisible breaks down boundaries between science and art
An exhibition bringing together science influencers and artists to explore the similarities in their working methods has opened at the Bush House Arcade.

Lecturer receives Supervisory Excellence Award
Dr Rivka Isaacson from the Department of Chemistry, has been awarded the King’s Supervisory Excellence Award for the Faculty of Natural & Mathematical...

Events

Department of Chemistry Seminar: Dr Doryen Bubeck
Senior Lecturer in Structural Biology, Department of Life Sciences, Imperial College London
Please note: this event has passed.
Developmentally regulated proteolysis by MdfA and ClpCP mediates metabolic differentiation during Bacillus subtilis sporulation
Riley, E. P., Lyda, J. A., Reyes-Matte, O., Sugie, J., Kasu, I. R., Enustun, E., Armbruster, E. G., Ravishankar, S., Isaacson, R. L., Camp, A. H., Lopez-Garrido, J. & Pogliano, K., 1 Apr 2025, In: Genes & development. 39, 7-8, p. 524-537 14 p.Research output: Contribution to journal › Article › peer-review
MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore
Massoni, S. C., Evans, N. J., Hantke, I., Fenton, C., Torpey, J. H., Collins, K. M., Krysztofinska, E. M., Muench, J. H., Thapaliya, A., Martínez-Lumbreras, S., Hart Ferrell, S., Slater, C., Wang, X., Fekade, R., Obwar, S., Yin, S., Vazquez, A., Prior, C. B., Turgay, K. & Isaacson, R. L. & 1 others, Camp, A. H., 1 Apr 2025, In: Genes & development. 39, 7, p. 510-523 14 p.Research output: Contribution to journal › Article › peer-review
Drug Discovery: How to exploit the recycling system of a cell
Evans, S., Haynes, B., Capatina, D. & Isaacson, R., 21 Feb 2025, In: eLife.Research output: Contribution to journal › Editorial
Biochemical methods for producing and characterising recombinant spider silks
Isaacson, R., Maraldo, A., Evans, S., Torpey, J., Rawal, A., Yarger, J., Marquis, C. & Blamires, S., 21 Jan 2025, In: Frontiers in Arachnid Science.Research output: Contribution to journal › Review article › peer-review
‘It depends on the liver’: Alcoholism, Detoxification, Regeneration and Wound-healing in A Fairly Honourable Defeat
Isaacson, R., 1 Sept 2024, In: The Iris Murdoch Review. 15, p. 61-70 10 p.Research output: Contribution to journal › Article › peer-review
Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis
Ablat, G., Lawton, N., Alam, R., Haynes, B. A., Hossain, S., Hicks, T., Evans, S. L., Jarvis, J. A., Nott, T. J., Isaacson, R. L. & Müller, M. M., 14 Aug 2024, In: Journal of the American Chemical Society. 146, 32, p. 22622-22628 7 p.Research output: Contribution to journal › Article › peer-review
A novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore
Massoni, S. C., Evans, N., Hantke, I., Fenton, C., Torpey, J., Collins, K., Krysztofinska, E., Muench, J., Thapaliya, A., Martinez Lumbreras, S., Hart Martin, S., Prior, C. B., Turgay, K., Isaacson, R. & Camp, A. H., 3 Mar 2024, In: bioRxiv.Research output: Contribution to journal › Article
Celestial sabbatical
Isaacson, R., 5 Jun 2024, In: Nature Physics. 20, p. 883 1 p.Research output: Contribution to journal › Book/Film/Article review › peer-review
Olga Kennard as an Icon of Interdisciplinarity
Isaacson, R., 17 Apr 2024, In: CRYSTAL GROWTH AND DESIGN. 24, 8, p. 3095-3099 5 p.Research output: Contribution to journal › Editorial › peer-review
Meeting Reports: Third Engineering Recombinant Proteins for Structural and Functional Studies Training Course, 10–11 November 2022, University of Liverpool
Stollar, E., Burgess-Brown, N. & Isaacson, R., 5 Jan 2024, In: Biochemist. 45, 5, 40.Research output: Contribution to journal › Article › peer-review
p97 and close encounters of every kind: A brief review
Dreveny, I., Pye, V. E., Beuron, F., Briggs, L. C., Isaacson, R. L., Matthews, S. J., McKeown, C., Yuan, X., Zhang, X. & Freemont, P. S., Nov 2004, In: Biochemical Society Transactions. 32, 5, p. 715-720 6 p.Research output: Contribution to journal › Article › peer-review
Elucidating the mechanism of familial amyloidosis-Finnish type: NMR studies of human gelsolin domain 2
Kazmirski, S. L., Howard, M. J., Isaacson, R. L. & Fersht, A. R., 26 Sept 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 20, p. 10706-10711 6 p.Research output: Contribution to journal › Article › peer-review
Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type
Isaacson, R. L., Weeds, A. G. & Fersht, A. R., 28 Sept 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11247-11252 6 p.Research output: Contribution to journal › Article › peer-review
Detailed structural insights into the p97-Npl4-Ufd1 interface
Isaacson, R. L., Pye, V. E., Simpson, P., Meyer, H. H., Zhang, X., Freemont, P. S. & Matthews, S., 20 Jul 2007, In: Journal of Biological Chemistry. 282, 29, p. 21361-21369 9 p.Research output: Contribution to journal › Article › peer-review
A new labeling method for methyl transverse relaxation-optimized spectroscopy NMR spectra of alanine residues
Isaacson, R. L., Simpson, P. J., Liu, M., Cota, E., Zhang, X., Freemont, P. & Matthews, S., 19 Dec 2007, In: Journal of the American Chemical Society. 129, 50, p. 15428-15429 2 p.Research output: Contribution to journal › Article › peer-review
Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: Variations in yield, growth, and differentiation
Phinney, D. G., Kopen, G., Isaacson, R. L. & Prockop, D. J., 15 Mar 1999, In: Journal of Cellular Biochemistry. 72, 4, p. 570-585 16 p.Research output: Contribution to journal › Article › peer-review
Loss of a metal-binding site in gelsolin leads to familial amyloidosis-finnish type
Kazmirski, S. L., Isaacson, R. L., An, C., Buckle, A., Johnson, C. M., Daggett, V. & Fersht, A. R., 2002, In: Nature Structural Biology. 9, 2, p. 112-116 5 p.Research output: Contribution to journal › Article › peer-review
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites
Park, S., Isaacson, R., Kim, H. T., Silver, P. A. & Wagner, G., Jul 2005, In: Structure. 13, 7, p. 995-1005 11 p.Research output: Contribution to journal › Article › peer-review
Conformational changes in the AAA ATPase p97-p47 adaptor complex
Beuron, F., Dreveny, I., Yuan, X., Pye, V. E., Mckeown, C., Briggs, L. C., Cliff, M. J., Kaneko, Y., Wallis, R., Isaacson, R. L., Ladbury, J. E., Matthews, S. J., Kondo, H., Zhang, X. & Freemont, P. S., 3 May 2006, In: EMBO Journal. 25, 9, p. 1967-1976 10 p.Research output: Contribution to journal › Article › peer-review
Targeting bacterial degradation machinery as an antibacterial strategy
Petkov, R., Camp, A. H., Isaacson, R. L. & Torpey, J. H., 15 Nov 2023, In: Biochemical Journal. 480, 21, p. 1719-1731 13 p.Research output: Contribution to journal › Review article › peer-review
Structural Analysis of Bacillus subtilis Sigma Factors
Collins, K. M., Evans, N. J., Torpey, J. H., Harris, J. M., Haynes, B. A., Camp, A. H. & Isaacson, R. L., 20 Apr 2023, In: Microorganisms. 11, 4, 1077.Research output: Contribution to journal › Article › peer-review
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains
Morris, O. M., Torpey, J. H. & Isaacson, R. L., 1 Oct 2021, In: Open Biology. 11, 10, p. 210222 1 p., 210222.Research output: Contribution to journal › Article › peer-review
Viewing the Invisible: Exploring common methodology across disciplines
Witheridge, A. & Isaacson, R., Dec 2019, In: PLoS Biology. 17, 12, p. e3000577 e3000577.Research output: Contribution to journal › Article › peer-review
Editorial: Weak interactions in molecular machinery
Isaacson, R. L. & Díaz-Moreno, I., 1 Jan 2019, In: Frontiers in Molecular Biosciences. 5, JAN, 117.Research output: Contribution to journal › Editorial › peer-review
The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease
Benarroch, R., Austin, J. M., Ahmed, F. & Isaacson, R. L., 18 Dec 2018, (E-pub ahead of print) In: Advances in Protein Chemistry and Structural Biology.Research output: Contribution to journal › Article › peer-review
Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control
Martínez-Lumbreras, S., Krysztofinska, E. M., Thapaliya, A., Spilotros, A., Matak-Vinkovic, D., Salvadori, E., Roboti, P., Nyathi, Y., Muench, J. H., Roessler, M. M., Svergun, D. I., High, S. & Isaacson, R. L., 11 Jul 2018, In: BMC Biology. 16, 1, 18 p., 76.Research output: Contribution to journal › Article › peer-review
Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB
Martínez-Lumbreras, S., Alfano, C., Evans, N. J., Collins, K. M., Flanagan, K. A., Atkinson, R. A., Krysztofinska, E. M., Vydyanath, A., Jackter, J., Fixon-Owoo, S., Camp, A. H. & Isaacson, R. L., 8 Mar 2018, (E-pub ahead of print) In: Structure.Research output: Contribution to journal › Article › peer-review
Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp
Krysztofinska, E. M., Evans, N. J., Thapaliya, A., Murray, J. W., Morgan, R. M. L., Martinez-Lumbreras, S. & Isaacson, R. L., 11 Oct 2017, In: Frontiers in Molecular Biosciences. 4, p. 68Research output: Contribution to journal › Article › peer-review
A Novel RNA Polymerase-binding Protein that interacts with a Sigma-Factor Docking Site
Wang Erickson, A. F., Deighan, P., Chen, S., Barrasso, K., Garcia, C. P., Martínez-Lumbreras, S., Alfano, C., Krysztofinska, E. M., Thapaliya, A., Camp, A. H., Isaacson, R. L., Hochschild, A. & Losick, R., 19 Jun 2017, (E-pub ahead of print) In: Molecular Microbiology.Research output: Contribution to journal › Article › peer-review
SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism
Thapaliya, A., Nyathi, Y., Martinez Lumbreras, S., Krysztofinska, E., Evans, N., Terry, I. L., High, S. & Isaacson, R. L., 9 Nov 2016, (E-pub ahead of print) In: Scientific Reports. 6, 12 p., 36622.Research output: Contribution to journal › Article › peer-review
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse
Ingham, N. J., Carlisle, F., Pearson, S., Lewis, M. A., Buniello, A., Chen, J., Isaacson, R. L., Pass, J., White, J. K., Dawson, S. J. & Steel, K. P., 2016, In: Scientific Reports. 6, p. 1-13 13 p., 28964.Research output: Contribution to journal › Article › peer-review
Structural and functional insights into the E3 ligase, RNF126
Krysztofinska, E. M., Martínez-Lumbreras, S., Thapaliya, A., Evans, N. J., High, S. & Isaacson, R. L., 19 May 2016, (E-pub ahead of print) In: Scientific Reports. 6, 26433.Research output: Contribution to journal › Article › peer-review
Autosomal-Recessive Hearing Impairment due to Rare Missense Variants within S1PR2
Santos-Cortez, R. L. P., Faridi, R., Rehman, A. U., Lee, K., Ansar, M., Wang, X., Morell, R. J., Isaacson, R., Belyantseva, I. A., Dai, H., Acharya, A., Qaiser, T. A., Muhammad, D., Ali, R. A., Shams, S., Hassan, M. J., Shahzad, S., Raza, S. I., Bashir, Z.-E.-H. & Smith, J. D. & 7 others, Nickerson, D. A., Bamshad, M. J., Riazuddin, S., Ahmad, W., Friedman, T. B., Leal, S. M. & University of Washington Center for Mendelian Genomics, 21 Jan 2016, (E-pub ahead of print) In: American Journal of Human Genetics. 98, 2, p. 331-338 7 p.Research output: Contribution to journal › Article › peer-review
Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha
Roberts, J. D., Thapaliya, A., Martínez-Lumbreras, S., Krysztofinska, E. M. & Isaacson, R. L., 18 Dec 2015, In: Frontiers in Bioscience. 2, p. 71Research output: Contribution to journal › Article › peer-review
1H, 13C and 15N assignments of Sgt2 N-terminal dimerisation domain and its binding partner, Get5 Ubiquitin-like domain
Simon, A. C., Simpson, P. J., Hawthorne, W., Hale, L. R., Goldstone, R. M. & Isaacson, R. L., Oct 2013, In: Biomolecular NMR Assignments. 7, 2, p. 271-4 4 p.Research output: Contribution to journal › Article › peer-review
ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure
Buyandelger, B., Mansfield, C., Kostin, S., Choi, O., Roberts, A. M., Ware, J. S., Mazzarotto, F., Pesce, F., Buchan, R., Isaacson, R., Vouffo, J., Gunkel, S., Knöll, G., McSweeney, S. J., Wei, H., Perrot, A., Pfeiffer, C., Toliat, M. R., Ilieva, K. & Krysztofinska, E. & 27 others, López-Olañeta, M. M., Gómez-Salinero, J. M., Schmidt, A., Ng, K.-E., Teucher, N., Chen, J., Teichmann, M., Eilers, M., Haverkamp, W., Regitz-Zagrosek, V., Hasenfuss, G., Braun, T., Pennell, D. J., Gould, I., Barton, P. J. R., Lara-Pezzi, E., Schafer, S., Hübner, N., Felkin, L. E., O'Regan, D. P., Petretto, E., Brand, T., Milting, H., Nürnberg, P., Schneider, M. D., Prasad, S. & Knöll, R., Oct 2015, In: Circulation-Cardiovascular Genetics. 8, 5, p. 643-652 9 p.Research output: Contribution to journal › Article › peer-review
Solution Structure of the SGTA Dimerisation Domain and Investigation of Its Interactions with the Ubiquitin-Like Domains of BAG6 and UBL4A
Darby, J. F., Krysztofinska, E. M., Simpson, P. J., Simon, A. C., Leznicki, P., Sriskandarajah, N., Bishop, D. S., Hale, L. R., Alfano, C., Conte, M. R., Martínez-Lumbreras, S., Thapaliya, A., High, S. & Isaacson, R. L., 21 Nov 2014, In: PLOS One. 9, 11, 19 p., e113281.Research output: Contribution to journal › Article › peer-review
Insights into adaptor binding to the AAA protein p97
Yeung, H. O., Kloppsteck, P., Niwa, H., Isaacson, R., Matthews, S., Zhang, X. & Freemont, P. S., Feb 2008, In: Biochemical Society Transactions. 36, 1, p. 62-67 6 p.Research output: Contribution to journal › Article › peer-review
Automated Assignment in Selectively Methyl-Labeled Proteins
Xu, Y., Liu, M., Simpson, P. J., Isaacson, R., Cota, E., Marchant, J., Yang, D., Zhang, X., Freemont, P. & Matthews, S., 15 Jul 2009, In: Journal of the American Chemical Society. 131, 27, p. 9480-9481 1 p.Research output: Contribution to journal › Article › peer-review
Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting
Simpson, P. J., Schwappach, B., Dohlman, H. G. & Isaacson, R., 11 Aug 2010, In: Structure. 18, 8, p. 897-902 6 p.Research output: Contribution to journal › Literature review › peer-review
Protein construct optimization: data sharing strategy
Polizzi, K. M. & Isaacson, R., May 2012, In: Protein & cell. 3, 5, p. 321-322 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins
Simon, A. C., Simpson, P. J., Goldstone, R. M., Krysztofinska, E. M., Murray, J. W., High, S. & Isaacson, R., 22 Jan 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1327-1332 6 p.Research output: Contribution to journal › Article › peer-review
The Association of BAG6 with SGTA and Tail-Anchored Proteins
Leznicki, P., Roebuck, Q. P., Wunderley, L., Clancy, A., Krysztofinska, E. M., Isaacson, R. L., Warwicker, J., Schwappach, B. & High, S., 22 Mar 2013, In: PL o S One . 8, 3, 15 p., e59590.Research output: Contribution to journal › Article › peer-review
Structural Insights into Serine-rich Fimbriae from Gram-positive Bacteria
Ramboarina, S., Garnett, J. A., Zhou, M., Li, Y., Peng, Z., Taylor, J. D., Lee, W.-C., Bodey, A., Murray, J. W., Alguel, Y., Bergeron, J., Bardiaux, B., Sawyer, E., Isaacson, R., Tagliaferri, C., Cota, E., Nilges, M., Simpson, P., Ruiz, T. & Wu, H. & 1 others, Matthews, S., 15 Oct 2010, In: Journal of Biological Chemistry. 285, 42, p. 32446 - 32457 12 p.Research output: Contribution to journal › Article › peer-review
Research

Microbes in Health & Disease
The Microbes in Health & Diseases Research Interest Group aims to foster collaboration across departments and faculties at KCL to explore the multifaceted role microbes play in health and disease.
News
Scientists discover protein key to bacteria's survival in extreme environments
The discovery sheds light on how certain bacteria form spores for survival, enabling superbugs to evade hospital cleaning

King's Chemist joins science greats in prestigious Royal Institution Christmas Lecture
Professor Rivka Isaacson helped reveal the truth about Artificial Intelligence in a three-part special series on BBC 4.

International Women's Day 2021: The contribution of the women at King's to the global response to COVID-19
As part of the UN’s International Women’s Day 2021 theme “Women in leadership: Achieving an equal future in a COVID-19 world”, we recognise the important...

King's chemist Dr Rivka Isaacson shortlisted as Falling Walls finalist
Rivka’s collaboration with the London Fine Arts studio via the 2019 multimedia project Viewing the Invisible has been shortlisted in the Science in the Arts...

Viewing the Invisible offers a fresh approach to thinking about science and art
The exhibition showcased parallels between the two disciplines and enabled a greater understanding of the value of collaborative working.

Viewing the Invisible breaks down boundaries between science and art
An exhibition bringing together science influencers and artists to explore the similarities in their working methods has opened at the Bush House Arcade.

Lecturer receives Supervisory Excellence Award
Dr Rivka Isaacson from the Department of Chemistry, has been awarded the King’s Supervisory Excellence Award for the Faculty of Natural & Mathematical...

Events

Department of Chemistry Seminar: Dr Doryen Bubeck
Senior Lecturer in Structural Biology, Department of Life Sciences, Imperial College London
Please note: this event has passed.