Dr Robert Köchl Academics Supervisors Senior Lecturer Research subject areas Immunology Contact details robert.koechl@kcl.ac.uk +44 (0) 20 7848 9612
B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Hayward, D. A., Vanes, L., Wissmann, S., Sivapatham, S., Hartweger, H., O'May, J. B., de Boer, L. L., Mitter, R., Köchl, R., Stein, J. V. & Tybulewicz, V. L. J., 6 Mar 2023, In: The Journal of experimental medicine. 220, 3 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1084/jem.20211827 The CD169+ macrophage actin cytoskeleton regulates membrane topography, immune complex mobility and B cell activation Iliopoulou, M., Bajur, A. T., McArthur, H., Coyle, C., Ajao, F., Köchl, R., Cope, A. & Spillane, K. M., 10 Feb 2023, In: Biophysical Journal. 122, 3S1, p. 409a Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.bpj.2022.11.2222 Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis Mayes-Hopfinger, L., Enache, A., Xie, J., Huang, C. L., Köchl, R., Tybulewicz, V. L. J., Fernandes-Alnemri, T. & Alnemri, E. S., Dec 2021, In: Nature Communications. 12, 1, 4546. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-021-24784-4 Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration Krause, M., Stramer, B., Ameer-Beg, S., Poland, S., Levitt, J., Marcotti, S., Köchl, R., Pallett, T., Law, A-L., Binti Abd Jalal, S. & Mosis, F., 28 Sep 2021, In: Nature Communications. 12, 1, 1 p., 5687. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41467-021-25916-6 Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency: Nox2-deficient Tregs improve heart allograft outcome Cellone Trevelin, S., Zampetaki, A., Sawyer, G., Ivetic, A., Brewer, A., Smith, L. A., Marelli-Berg, F. M., Köchl, R., Lechler, R. I., Shah, A. & Lombardi, G., 22 Sep 2021, In: JCI Insight. 6, 18, p. e149301 12 p., e149301. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1172/jci.insight.149301 LFA-1 in T cell priming, differentiation, and effector functions Gérard, A., Cope, A. P., Kemper, C., Alon, R. & Köchl, R., Aug 2021, In: TRENDS IN IMMUNOLOGY. 42, 8, p. 706-722 17 p. Research output: Contribution to journal › Review article › peer-review. DOIs: https://doi.org/10.1016/j.it.2021.06.004 Critical role of WNK1 in MYC-dependent early mouse thymocyte development Köchl, R., Vanes, L., Llorian Sopena, M., Chakravarty, P., Hartweger, H., Fountain, K., White, A., Cowan, J., Anderson, G. & Tybulewicz, V. L., 14 Oct 2020, In: eLife. 9, p. 1-32 32 p., e56934. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.7554/eLife.56934 Corrigendum: WNK1 kinase balances T cell adhesion versus migration in vivo Köchl, R., Thelen, F., Vanes, L., Brazão, T. F., Fountain, K., Xie, J., Huang, C-L., Lyck, R., Stein, J. V. & Tybulewicz, V. L. J., 19 Jan 2017, In: Nature Immunology. 18, 2, p. 246 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/ni0217-246a WNK1 kinase balances T cell adhesion versus migration in vivo Köchl, R., Thelen, F., Vanes, L., Brazão, T. F., Fountain, K., Xie, J., Huang, C. L., Lyck, R., Stein, J. V. & Tybulewicz, V. L. J., 1 Sep 2016, In: Nature Immunology. 17, 9, p. 1075-1083 9 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/ni.3495 Mechanism and function of Vav1 localisation in TCR signalling Ksionda, O., Saveliev, A., Köchl, R., Rapley, J., Faroudi, M., Smith-Garvin, J. E., Wülfing, C., Rittinger, K., Carter, T. & Tybulewicz, V. L. J., 15 Nov 2012, In: Journal of Cell Science. 125, 22, p. 5302-5314 13 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1242/jcs.105148 View all publications