Asthma & Allergy
A bench to bedside approach for asthma, allergy and cancer research. We aim to elucidate the molecular mechanisms underlying allergic disease and facilitate the development of new therapies. Combining techniques in structural biology, molecular genetics and cell biology, we study the allergic response from the control of IgE antibody gene expression to the various protein-receptor interactions that mediate the physiological allergic responses. Our joint projects link the basic science with clinical research.
Some Randall staff are also members of the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma. A joint initiative with Imperial College, the Centre brings together research groups at both universities, providing common core facilities and a network of basic science and clinical collaborations across a number of London hospitals.
Muscle and heart research are traditional and strong activities in the Randall Centre, which hosts several groups pursuing fundamental research into skeletal and heart muscle contraction mechanisms and development, as well as the BHF Chair of Molecular Cardiology. The Centre has strong links to the school of Cardiovascular Sciences and Medicine, hosting two embedded staff, and with co-appointed clinical staff in the Evelina London Children's Hospital on research into the mechanisms of heart and muscle diseases in children.
Multidisciplinary research activity based on cell motility, cancer biology and cell imaging is strongly linked to the Translational Cancer Medicine activities of the Comprehensive Cancer Centre. We have a number of co-appointed staff and share facilities in Imaging and Computational Bioimedicine.