Postdoctoral Research Associate
Paclitaxel-assisted balloon angioplasty of venous stenosis in haemodialysis access (PAVE RCT)
Reliable vascular access is essential for patients receiving haemodialysis. An arteriovenous fistula is the preferred option; however, these are prone to developing stenotic segments. These lesions are treated with angioplasty, but there is a high rate of recurrence. We recently completed the NIHR funded PAVE trial which showed no benefit for paclitaxel coated balloons. The trial result has generated much discussion (see accompanying editorial) as a trial with a different paclitaxel coated balloon did shown an effect. We are currently planning another large trial to assess other types of drug-coated balloons.
Myeloperoxidase inhibition as a potential therapy in anti- neutrophil cytoplasmic antibody vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis is a systemic disease caused by small vessel inflammation, with clinical manifestations that include crescentic glomerulonephritis and pulmonary haemorrhage. We have previously published work assessing mechanisms using a preclinical model of this disease. In this MRC funded project, we are testing myeloperoxidase inhibition as a potential therapy.
Novel pathways involving ANCA and monocytes in ANCA vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis is a systemic disease caused by small vessel inflammation, with clinical manifestations that include crescentic glomerulonephritis and pulmonary haemorrhage. It is characterised by the presence of autoantibodies to myeloperoxidase and proteinase-3, which bind monocytes in addition to neutrophils. While a pathological effect on neutrophils is acknowledged, the impact of ANCA on monocyte function is less well understood. This work explores novel effects of ANCA on monocytes and may suggest therapeutic targets.
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Wilkinson, H., Leonard, H., Robson, M., Smith, R., Tam, E., McVey, J. H., Kirchhofer, D., Chen, D. & Dorling, A., 12 Sep 2022, In: Frontiers in immunology. 13, 999871. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3389/fimmu.2022.999871
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Robson, M., 2021, In: Kidney International. Research output: Contribution to journal › Letter › peer-review. DOIs: https://doi.org/10.1016/j.kint.2021.05.019
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Hakki, S., Robinson, E. J. & Robson, M. G., Dec 2022, In: Scientific Reports. 12, 1, 1427. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1038/s41598-022-05062-9
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Flórez-Barrós, F., Freeley, S. J., Tham, E-L. & Robson, M. G., 13 Nov 2021, (Accepted/In press) In: Glomerular Diseases. Research output: Contribution to journal › Article › peer-review
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Freeley, S. J., Tham, E. L. & Robson, M. G., Feb 2022, In: NEPHROLOGY. 27, 2, p. 208-214 7 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1111/nep.13988
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Karunanithy, N., Robinson, E. J., Calder, F., Dorling, A., Peacock, J., Wang, Y., Gardner, L. M. & Robson, M., 27 Sep 2021, In: Efficacy and Mechanism Evaluation. 8, 13 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.3310/eme08130
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Karunanithy, N., Robinson, E. J., Ahmad, F., Burton, J. O., Calder, F., Coles, S., Das, N., Dorling, A., Forman, C., Jaffer, O., Lawman, S., Lakshminarayan, R., Lewlellyn, R., Peacock, J. L., Ramnarine, R., Mesa, I. R., Shaikh, S., Simpson, J., Steiner, K., Suckling, R., & 8 othersSzabo, L., Turner, D., Wadoodi, A., Wang, Y., Weir, G., Wilkins, C. J., Gardner, L. M. & Robson, M. G., Aug 2021, In: Kidney International. 100, 2, p. 447-456 10 p. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.kint.2021.02.040
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Spencer, J., Tull, T., Pitcher, M., Guesdon, W., Siu, J. HY., Lebraro-Fernandez, C., Zhao, Y., Petrov, N., Heck, S., Ellis, R., Dhami, P., kadolsky, U., Kleeman, M., Kamra, Y., Fear, D., John, S., Jassem, W., Groves, R., Sanderson, J. D., Robson, M., & 2 othersD’Cruz, D. & Bemark, M., 5 Apr 2021, In: Journal of Experimental Medicine. 218, 4, e20202001. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1084/jem.20202001
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Wilkinson, H., Leonard, H., Chen, D., Lawrence, T., Robson, M., Goossens, P., McVey, JH. & Dorling, A., 22 Jan 2021, In: iScience. 24, 1, 101981. Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.isci.2020.101981
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Tham, E. L., Freeley, S., Bearder, S., Florez Barros, F., Cragg, M. S., Mocsai, A. & Robson, M., 30 Sep 2020, In: Journal of Autoimmunity. 113, p. 102501 Research output: Contribution to journal › Article › peer-review. DOIs: https://doi.org/10.1016/j.jaut.2020.102501