My lab aims to understand the biology of γδ T cells in human tissues and cancers. These cells are seeded perinatally and developmentally into steady-state tissues without obvious inflammatory triggers. Whilst they can readily mount local and rapid responses to cancer, their presence at steady state suggests a nuanced role which balances self-tolerance versus tumour-rejection. In juxtaposition, effective and manageable cancer immunotherapy is fundamentally a balance of tolerance versus rejection. Thus, tissue-resident γδ T cells would seem critical to cancer immunosurveillance as they straddle this dichotomy, yet they remain understudied in human health and disease.
Our Partners
Wellcome Trust
Group lead
Wellcome Trust Clinical Research Career Development Fellow & Honorary Consultant Medical Oncologist