Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets.
Povoleri GAM, Durham LE, Gray EH, Lalnunhlimi S, Kannambath S, Pitcher MJ, Dhami P, Leeuw T, Ryan SE, Steel KJA, Kirkham BW, Taams LS.Cell Rep. 2023 May 30;42(5):112514. doi: 10.1016/j.celrep.2023.112514. Epub 2023 May 16.PMID: 37195862
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael BD, Dunai C, Needham EJ, Tharmaratnam K, Williams R, Huang Y, Boardman SA, Clark JJ, Sharma P, Subramaniam K, Wood GK, Collie C, Digby R, Ren A, Norton E, Leibowitz M, Ebrahimi S, Fower A, Fox H, Tato E, Ellul MA, Sunderland G, Held M, Hetherington C, Egbe FN, Palmos A, Stirrups K, Grundmann A, Chiollaz AC, Sanchez JC, Stewart JP, Griffiths M, Solomon T, Breen G, Coles AJ, Kingston N, Bradley JR, Chinnery PF, Cavanagh J, Irani SR, Vincent A, Baillie JK, Openshaw PJ, Semple MG; ISARIC4C Investigators; COVID-CNS Consortium; Taams LS, Menon DK.Nat Commun. 2023 Dec 22;14(1):8487. doi: 10.1038/s41467-023-42320-4.
Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030.
MacKenzie G, Subramaniam S, Caldwell LJ, Fitzgerald D, Harrison NA, Hong S, Irani SR, Khandaker GM, Liston A, Miron VE, Mondelli V, Morgan BP, Pariante C, Shah DK, Taams LS, Teeling JL, Upthegrove R.Wellcome Open Res. 2021 Jul 29;6:194. doi: 10.12688/wellcomeopenres.16997.1. eCollection 2021.PMID: 34778569
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation.
Mijnheer G, Lutter L, Mokry M, van der Wal M, Scholman R, Fleskens V, Pandit A, Tao W, Wekking M, Vervoort S, Roberts C, Petrelli A, Peeters JGC, Knijff M, de Roock S, Vastert S, Taams LS, van Loosdregt J, van Wijk F.Nat Commun. 2021 May 11;12(1):2710. doi: 10.1038/s41467-021-22975-7.PMID: 33976194
Interleukin-17 in rheumatoid arthritis: Trials and tribulations.
Taams LS.J Exp Med. 2020 Mar 2;217(3):e20192048. doi: 10.1084/jem.20192048.PMID: 32023342
Keloid tissue analysis discredits a role for myofibroblasts in disease pathogenesis.
Bell RE, Shaw TJ.Wound Repair Regen. 2021 Jul;29(4):637-641. doi: 10.1111/wrr.12923. Epub 2021 May 7.PMID: 33961308
Metabolic perturbations in fibrosis.
Ung CY, Onoufriadis A, Parsons M, McGrath JA, Shaw TJ.Int J Biochem Cell Biol. 2021 Oct;139:106073. doi: 10.1016/j.biocel.2021.106073. Epub 2021 Aug 27.PMID: 34461262
Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression.
Opzoomer JW, Anstee JE, Dean I, Hill EJ, Bouybayoune I, Caron J, Muliaditan T, Gordon P, Sosnowska D, Nuamah R, Pinder SE, Ng T, Dazzi F, Kordasti S, Withers DR, Lawrence T, Arnold JN. Sci Adv. 2021 Nov 5;7(45):eabg9518. doi: 10.1126/sciadv.abg9518. Epub 2021 Nov 3.PMID: 34730997
NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity.
Ghislat G, Cheema AS, Baudoin E, Verthuy C, Ballester PJ, Crozat K, Attaf N, Dong C, Milpied P, Malissen B, Auphan-Anezin N, Manh TPV, Dalod M, Lawrence T. Sci Immunol. 2021 Jul 9;6(61):eabg3570. doi: 10.1126/sciimmunol.abg3570.PMID: 34244313
Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and cis-Spliced Zwitter Epitope Candidates in Type 1 Diabetes.
Mishto M, Mansurkhodzhaev A, Rodriguez-Calvo T, Liepe J. Front Immunol. 2021 Apr 15;12:656451. doi: 10.3389/fimmu.2021.656451. eCollection 2021.PMID: 33936085
Proteasome-Generated cis-Spliced Peptides and Their Potential Role in CD8+ T Cell Tolerance.
Mansurkhodzhaev A, Barbosa CRR, Mishto M, Liepe J. Front Immunol. 2021 Feb 24;12:614276. doi: 10.3389/fimmu.2021.614276. eCollection 2021.PMID: 33717099
Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030.
MacKenzie G, Subramaniam S, Caldwell LJ, Fitzgerald D, Harrison NA, Hong S, Irani SR, Khandaker GM, Liston A, Miron VE, Mondelli V, Morgan BP, Pariante C, Shah DK, Taams LS, Teeling JL, Upthegrove R.Wellcome Open Res. 2021 Jul 29;6:194. doi: 10.12688/wellcomeopenres.16997.1. eCollection 2021.PMID: 34778569
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation.
Mijnheer G, Lutter L, Mokry M, van der Wal M, Scholman R, Fleskens V, Pandit A, Tao W, Wekking M, Vervoort S, Roberts C, Petrelli A, Peeters JGC, Knijff M, de Roock S, Vastert S, Taams LS, van Loosdregt J, van Wijk F. Nat Commun. 2021 May 11;12(1):2710. doi: 10.1038/s41467-021-22975-7.PMID: 33976194
Cholesterol metabolism: a new molecular switch to control inflammation.
Cardoso D, Perucha E. Clin Sci (Lond). 2021 Jun 11;135(11):1389-1408. doi: 10.1042/CS20201394.PMID: 34086048
Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study.
Mahil SK, Bechman K, Raharja A, Domingo-Vila C, Baudry D, Brown MA, Cope AP, Dasandi T, Graham C, Khan H, Lechmere T, Malim MH, Meynell F, Pollock E, Sychowska K, Barker JN, Norton S, Galloway JB, Doores KJ, Tree T, Smith CH. Lancet Rheumatol. 2021 Nov 9. doi: 10.1016/S2665-9913(21)00333-7. Online ahead of print.PMID: 34778846
LFA-1 in T cell priming, differentiation, and effector functions.
Gérard A, Cope AP, Kemper C, Alon R, Köchl R. Trends Immunol. 2021 Aug;42(8):706-722. doi: 10.1016/j.it.2021.06.004. Epub 2021 Jul 12.PMID: 34266767
The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study.
Mahil SK, Bechman K, Raharja A, Domingo-Vila C, Baudry D, Brown MA, Cope AP, Dasandi T, Graham C, Lechmere T, Malim MH, Meynell F, Pollock E, Seow J, Sychowska K, Barker JN, Norton S, Galloway JB, Doores KJ, Tree TIM, Smith CH. Lancet Rheumatol. 2021 Sep;3(9):e627-e637. doi: 10.1016/S2665-9913(21)00212-5. Epub 2021 Jul 8.PMID: 34258590
Multi-color Molecular Visualization of Signaling Proteins Reveals How C-Terminal Src Kinase Nanoclusters Regulate T Cell Receptor Activation.
Simoncelli S, Griffié J, Williamson DJ, Bibby J, Bray C, Zamoyska R, Cope AP, Owen DM. Cell Rep. 2020 Dec 22;33(12):108523. doi: 10.1016/j.celrep.2020.108523.
A developmental basis for the anatomical diversity of dermis in homeostasis and wound repair.
Usansky I, Jaworska P, Asti L, Kenny FN, Hobbs C, Sofra V, Song H, Logan M, Graham A, Shaw TJ. J Pathol. 2020 Nov 16. doi: 10.1002/path.5589. Online ahead of print.
Imaging neoangiogenesis in rheumatoid arthritis (INIRA): whole-body synovial uptake of a 99mTc-labelled RGD peptide is highly correlated with power Doppler ultrasound.
Attipoe L, Chaabo K, Wajed J, Hassan FU, Shivapatham D, Morrison M, Ballinger J, Cook G, Cope AP, Garrood T. Ann Rheum Dis. 2020 Sep;79(9):1254-1255. doi: 10.1136/annrheumdis-2020-217228. Epub 2020 Apr 23.
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate.
Bibby JA, Purvis HA, Hayday T, Chandra A, Okkenhaug K, Rosenzweig S, Aksentijevich I, Wood M, Lachmann HJ, Kemper C, Cope AP, Perucha E. Nat Commun. 2020 Jul 8;11(1):3412. doi: 10.1038/s41467-020-17179-4.
IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4+ T Cells.
Ridley ML, Fleskens V, Roberts CA, Lalnunhlimi S, Alnesf A, O'Byrne AM, Steel KJA, Povoleri GAM, Sumner J, Lavender P, Taams LS. J Immunol. 2020 Jun 1;204(11):2940-2948. doi: 10.4049/jimmunol.1901283. Epub 2020 Apr 22.
Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease.
Shaw TJ, Rognoni E. Curr Rheumatol Rep. 2020 Jun 19;22(8):33. doi: 10.1007/s11926-020-00903-w.
What We See, What We Do Not See, and What We Do Not Want to See in HLA Class I Immunopeptidomes.
Mishto M. Proteomics. 2020 Jun 12:e2000112. doi: 10.1002/pmic.202000112. Online ahead of print.
Mechanisms of checkpoint inhibition-induced adverse events.
Urwyler P, Earnshaw I, Bermudez M, Perucha E, Wu W, Ryan S, Mcdonald L, Karagiannis SN, Taams LS, Powell N, Cope A, Papa S. Clin Exp Immunol. 2020 May;200(2):141-154. doi: 10.1111/cei.13421. Epub 2020 Feb 21.
Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes.
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Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.
Etzerodt A, Moulin M, Doktor TK, Delfini M, Mossadegh-Keller N, Bajenoff M, Sieweke MH, Moestrup SK, Auphan-Anezin N, Lawrence T. J Exp Med. 2020 Apr 6;217(4):e20191869. doi: 10.1084/jem.20191869.
Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis.
Steel KJA, Srenathan U, Ridley M, Durham LE, Wu SY, Ryan SE, Hughes CD, Chan E, Kirkham BW, Taams LS. Arthritis Rheumatol. 2020 Mar;72(3):435-447. doi: 10.1002/art.41156. Epub 2020 Feb 4.
Interleukin-17 in rheumatoid arthritis: Trials and tribulations.
Taams LS.J Exp Med. 2020 Mar 2;217(3):e20192048. doi: 10.1084/jem.20192048.
Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.
Purvis HA, Clarke F, Montgomery AB, Colas C, Bibby JA, Cornish GH, Dai X, Dudziak D, Rawlings DJ, Zamoyska R, Guermonprez P, Cope AP. Front Immunol. 2020 Mar 4;11:376. doi: 10.3389/fimmu.2020.00376. eCollection 2020.
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.
Etzerodt A, Tsalkitzi K, Maniecki M, Damsky W, Delfini M, Baudoin E, Moulin M, Bosenberg M, Graversen JH, Auphan-Anezin N, Moestrup SK, Lawrence T. J Exp Med. 2019 Oct 7;216(10):2394-2411. doi: 10.1084/jem.20182124. Epub 2019 Aug 2.
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP. Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9.