Title: Functional anatomy of cognitive training in chunking within working memory in Alzheimer’s disease.
Summary: In a previous study we have shown that individuals with early Alzheimer’s disease (AD) are able to use strategies to improve their working memory. I am currently conducting a randomised controlled trial to investigate whether simple working memory training, using a strategy known as ‘chunking’ can improve cognitive function. I am also using fMRI to examine whether there is underlying functional plasticity in prefrontal and parietal regions as a result of memory training.
Title: A blood-based diagnostic test for the early detection of Alzheimer's disease.
Summary: Using sophisticated proteomic techniques, my current work focuses on developing a blood-based diagnostic test to indentify Alzheimer's disease before the onset of symptoms. Currently the diagnosis of Alzheimer's disease is often captured too late, is inconsistent and costly; therefore, a cheap and simple blood test that can be routinely used in clinics would be ideal. This blood test could also contribute to the selection and stratification of patients for therapeutic drug trials.
Title: Longitudinal blood based biomarkers of Alzheimer's disease pathology in healthy elderly individuals.
Summary: The purpose of this research project is to identify peripheral biomarkers associated brain amyloid load, longitudinal changes in brain volume, and cognitive decline in non-demented older individuals. To do this I am performing proteomic analyses on plasma samples collected from participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging (BLSA).
Title: Development of a Quality Specialist Care Service for Older Adults
Summary: My PhD project is examining the effects on patients and costs of the redesign of specialist continuing care services within South London and Maudsley NHS Foundation Trust using a range of outcome measures including quality of life and safety incidents.
Title: Functional characterisation of rare risk variants in immune genes associated with Alzheimer's disease
Supervisors: Dr Angela Hodges and Dr Richard Killick
Costas Mistrellides, MSc